[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100574604":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":13,"studyPopulation":13,"armGroups":22,"interventions":35,"overallOfficials":13,"centralContacts":43,"locations":49,"responsibleParty":65,"collaborators":13,"id":67,"slug":13,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":13,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":13,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":13,"overallStatus":52,"whyStopped":13,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Wecare Probiotics Co., Ltd.","INDUSTRY",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Constipation symptom improvement","Assessing the improvement of constipation in patients using the Bristol Stool Form Scale (BSFS) . In this scale, higher scores indicate softer stool textures, closer to liquid consistency. Scores of 4, 5, and 6 are generally considered ideal stool characteristics.","8 weeks",null,{"allocation":15,"interventionModel":16,"interventionModelDescription":13,"primaryPurpose":17,"observationalModel":13,"timePerspective":13,"maskingInfo":18},"RANDOMIZED","PARALLEL","PREVENTION",{"masking":19,"maskingDescription":13,"whoMasked":20},"SINGLE",[21],"PARTICIPANT",[23,29],{"label":24,"type":25,"description":26,"interventionNames":27},"Probiotic","EXPERIMENTAL","Every day to Pediococcus acidilactici PA53 (30 billion CFU\u002Fday, 3g) intervention, for 8 weeks.\n\nStore in a cool and dry place.",[28],"Dietary Supplement: Probiotic",{"label":30,"type":31,"description":32,"interventionNames":33},"Placebo","PLACEBO_COMPARATOR","Every day to give 3 g maltodextrin intervention for 8 weeks. Store in a cool and dry place.",[34],"Dietary Supplement: Maltodextrin",[36,40],{"type":37,"name":24,"description":38,"armGroupLabels":39,"otherNames":13},"DIETARY_SUPPLEMENT","The experimental phase of this study had last 8 weeks and each patient will make 3 visits (week 0, week 4, week 8).",[24],{"type":37,"name":41,"description":38,"armGroupLabels":42,"otherNames":13},"Maltodextrin",[30],[44],{"name":45,"role":46,"phone":47,"phoneExt":13,"email":48},"Yuhan xia, Doctor","CONTACT","18336086291","1959643812@qq.com",[50],{"facility":51,"status":52,"city":53,"state":54,"zip":13,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"Department of Nutrition, General Hospital of Ningxia Medical University","RECRUITING","Yinchuan","Ningxia","China","CN",{"type":58,"coordinates":59},"Point",[60,61],106.27306,38.46806,{"lat":61,"lon":60},[64],{"name":45,"role":46,"phone":47,"phoneExt":13,"email":48},{"type":66,"investigatorFullName":13,"investigatorTitle":13,"investigatorAffiliation":13,"oldNameTitle":13,"oldOrganization":13},"SPONSOR","100574604",false,"NCT06761443","To Evaluate the Safety and Efficacy of Pediococcus Acidilactici PA53 in Relieving Constipation in Adults","Based on a Randomized, Double-blind, Placebo-controlled Trial, we Evaluated the Safety and Efficacy of Pediococcus Acidilactici PA53 in Relieving Constipation in Adults","Inclusion Criteria:\n\n1\\. Constipated subjects Subjects (less than 3 bowel movements per week and\u002For Bristol Scale Types 1 and 2); 2. Be able to complete the research according to the requirements of the test plan; 3. Subjects who have signed informed consent; 4. Subjects (including male subjects) have no family planning and voluntarily take effective contraceptive measures from 14 days before screening to 6 months after the end of the trial.\n\n\\-\n\nExclusion Criteria:\n\n1. Short-term use of items with similar functions to the subject, which affects the judge of the result;\n2. Those who changed their diet type during the study period;\n3. People with severe allergies and immune deficiencies;\n4. Women who are pregnant, breastfeeding or planning to become pregnant;\n5. Patients with serious diseases of cardiovascular, lung, liver, kidney and other vital organs, diabetes, thyroid disease, severe metabolic diseases, malignant tumors, and severe immune system diseases;\n6. People who have used antibiotics in the past two weeks;\n7. People with serious mental and mental illness;\n8. Failure to eat the test sample as required, or failure to follow up on time, resulting in uncertain efficacy;\n9. Other researchers judged it inappropriate to participate. -",true,"ALL","18 Years","70 Years",{"count":78,"type":79},10,"ESTIMATED","INTERVENTIONAL",[82],"NA","To study the improvement of constipation symptoms, quality of life and mental state, intestinal function, intestinal hormones, inflammation and immunity, and intestinal flora of constipation subjects after 8-week intervention with Pediococcus acidilactici PA53.",[85],"Constipation","2025-01-01",{"date":88,"type":89},"2025-01-07","ACTUAL",{"date":91,"type":79},"2025-02-25",{"date":93,"type":79},"2025-05-25",{"name":5,"class":6},1]