[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100507013":3},{"organization":4,"outcomesModule":7,"designInfo":18,"detailedDescription":17,"studyPopulation":21,"armGroups":17,"interventions":22,"overallOfficials":26,"centralContacts":30,"locations":35,"responsibleParty":54,"collaborators":17,"id":56,"slug":17,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":17,"eligibilityCriteria":60,"healthyVolunteers":57,"sex":61,"minAge":62,"maxAge":17,"enrollmentInfo":63,"targetDuration":17,"studyType":66,"phases":17,"briefSummary":67,"conditions":68,"keywords":17,"overallStatus":37,"whyStopped":17,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"University of Minnesota","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":17},[9],{"measure":10,"description":11,"timeFrame":12},"Time in seconds to AiO2 from 90 to 40%","Time in seconds to AiO2 from 90 to 40% after activating laser mode on the monsoon jet ventilator.","baseline",[14],{"measure":15,"description":16,"timeFrame":12},"Differences in time to laser mode AiO2","Differences in time to laser mode AiO2 between trachea and left and right mainstem bronchi.",null,{"allocation":17,"interventionModel":17,"interventionModelDescription":17,"primaryPurpose":17,"observationalModel":19,"timePerspective":20,"maskingInfo":17},"COHORT","PROSPECTIVE","Patients undergoing rigid bronchoscopy for treatment of central airway obstruction at FV UMMC will be identified.",[23],{"type":6,"name":24,"description":25,"armGroupLabels":17,"otherNames":17},"No intervention","This is an observational study",[27],{"name":28,"affiliation":5,"role":29},"Sudarshan Setty, MD","PRINCIPAL_INVESTIGATOR",[31],{"name":32,"role":33,"phone":17,"phoneExt":17,"email":34},"Candace Nelson","CONTACT","nelso377@umn.edu",[36],{"facility":5,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"RECRUITING","Minneapolis","Minnesota","55455","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-93.26384,44.97997,{"lat":47,"lon":46},[50],{"name":51,"role":33,"phone":52,"phoneExt":17,"email":53},"Pankhura Gupta","763-268-9823","gupta359@umn.edu",{"type":55,"investigatorFullName":17,"investigatorTitle":17,"investigatorAffiliation":17,"oldNameTitle":17,"oldOrganization":17},"SPONSOR","100507013",false,"NCT05881863","To Investigate Airway Oxygen Concentrations During Rigid Bronchoscopy Procedures Performed With High Frequency Jet Ventilation","Inclusion Criteria:\n\n* Patients undergoing rigid bronchoscopy for treatment of central airway obstruction at FV UMMC will be identified.\n* 18 years or older\n* Need rigid bronchoscopy as pre-determined by the interventional pulmonologist\n\nExclusion Criteria:\n\n* Refusal to sign consent\n* Pregnant patients\n* Hemodynamic instability defined as continuous infusion of medication in order to support blood pressure and\u002For heart rate\u002Frhythm\n* Respiratory instability defined as SpO2\\<90% with \\>90% supplemental oxygen.\n* Ineligible for rigid bronchoscopic intubation\n* Latex allergy\n* Evidence of fistulous airway\n* Active Bronchopleural fistula","ALL","18 Years",{"count":64,"type":65},50,"ESTIMATED","OBSERVATIONAL","Thermal ablation (use of treatment modalities that generate heat) has become a widely used tool for treatment of central airway obstruction (e.g. laser, electrocautery, radiofrequency, and argon plasma coagulation). However, this method carries with it an increased risk for airway fire - a surgical fire that occurs in a patient's airway and could also include a fire in the attached breathing circuit. To decrease the risk of airway fire during mechanical ventilation with an endotracheal tube, the concentration of inspired oxygen (FiO2) is set below 40% while waiting for end tidal oxygen concentration (EtO2) to fall below 40% prior to starting thermal ablation. There is no published literature describing O2 concentration within the airways (AiO2) during jet ventilation with rigid bronchoscopy. The co-investigators of this study have recently collected data on AiO2 during rigid bronchoscopy using manual low frequency jet ventilation\u002Fhigh frequency jet ventilation with a period of apnea. The intent of this study is to measure the time taken for the central airway oxygen concentration to drop from 90 to 40% when the \"laser mode\" is activated on the Monsoon jet ventilator. Ventilation is continued during \"laser mode.\"",[69],"Central Airway Obstruction","2026-01-05",{"date":72,"type":73},"2026-01-07","ACTUAL",{"date":75,"type":73},"2024-01-12",{"date":77,"type":65},"2026-12-31",{"name":5,"class":6},1]