[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577715":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":33,"locations":42,"responsibleParty":183,"collaborators":11,"id":185,"slug":11,"hasResults":186,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":190,"eligibilityCriteria":191,"healthyVolunteers":186,"sex":192,"minAge":193,"maxAge":11,"enrollmentInfo":194,"targetDuration":11,"studyType":197,"phases":198,"briefSummary":200,"conditions":201,"keywords":11,"overallStatus":76,"whyStopped":11,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":212},{"fullName":5,"class":6},"Insel Gruppe AG, University Hospital Bern","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Total pancreatectomy (TP)","EXPERIMENTAL",null,[13],"Procedure: Total pancreatectomy (TP)",{"label":15,"type":16,"description":11,"interventionNames":17},"Pancreaticoduodenectomy (PD)","ACTIVE_COMPARATOR",[18],"Procedure: Partial pancreaticoduodenectomy (PD)",[20,24],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":11},"PROCEDURE","The investigators perform TP in patients who undergo surgical resection of a malignant tumor in the pancreatic head.",[9],{"type":21,"name":25,"description":26,"armGroupLabels":27,"otherNames":11},"Partial pancreaticoduodenectomy (PD)","The investigators perform partial PD with anastomosis of the pancreas in patients who undergo surgical resection of a malignant tumor in the pancreatic head. This is the current standard procedure.",[15],[29],{"name":30,"affiliation":31,"role":32},"Anna S Wenning, MD, PhD","Department of Visceral Surgery and Medicine Inselspital, Bern University Hospital","PRINCIPAL_INVESTIGATOR",[34,38],{"name":30,"role":35,"phone":36,"phoneExt":11,"email":37},"CONTACT","+41 (0)31 632 71 41","annasilvia.wenning@insel.ch",{"name":39,"role":35,"phone":40,"phoneExt":11,"email":41},"Nadine Uebersax","+41 (0)31 684 33 69","nadine.uebersax@unibe.ch",[43,60,74,90,104,118,130,144,158,172],{"facility":44,"status":45,"city":46,"state":11,"zip":47,"country":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Department of General, Visceral and Transplantation Surgery, University Hospital Münster","NOT_YET_RECRUITING","Münster","48149","Germany",{"type":50,"coordinates":51},"Point",[52,53],7.62571,51.96236,{"lat":53,"lon":52},[56],{"name":57,"role":35,"phone":58,"phoneExt":11,"email":59},"Prof. Dr. med. Andreas Pascher","+49 251 83 56304","sekretariatavtc@ukmuenster.de",{"facility":61,"status":45,"city":62,"state":11,"zip":63,"country":48,"cosmosGeoPoint":64,"geoPoint":68,"contacts":69},"Department of General and Visceral Surgery, University Hospital Ulm","Ulm","89081",{"type":50,"coordinates":65},[66,67],9.99155,48.39841,{"lat":67,"lon":66},[70],{"name":71,"role":35,"phone":72,"phoneExt":11,"email":73},"Prof. Dr. med. Emrullah Birgin","+49 731 500 53 501","emrullah.birgin@uniklinik-ulm.de",{"facility":75,"status":76,"city":77,"state":11,"zip":78,"country":79,"cosmosGeoPoint":80,"geoPoint":84,"contacts":85},"Department of General and Visceral Surgery, Kantonsspital Aarau","RECRUITING","Aarau","5001","Switzerland",{"type":50,"coordinates":81},[82,83],8.04422,47.39254,{"lat":83,"lon":82},[86],{"name":87,"role":35,"phone":88,"phoneExt":11,"email":89},"PD Dr. med. Philipp Kron","+41 62 838 55 80","philipp.kron@ksa.ch",{"facility":91,"status":76,"city":92,"state":11,"zip":93,"country":79,"cosmosGeoPoint":94,"geoPoint":98,"contacts":99},"Department of Surgery, Kantonsspital Baden","Baden","5404",{"type":50,"coordinates":95},[96,97],8.30592,47.47333,{"lat":97,"lon":96},[100],{"name":101,"role":35,"phone":102,"phoneExt":11,"email":103},"Prof. Dr. med. Antonio Nocito","+41 56 486 30 02","antonio.nocito@ksb.ch",{"facility":105,"status":76,"city":106,"state":11,"zip":107,"country":79,"cosmosGeoPoint":108,"geoPoint":112,"contacts":113},"Department of Visceral Surgery, University Hospital Basel","Basel","4031",{"type":50,"coordinates":109},[110,111],7.57327,47.55839,{"lat":111,"lon":110},[114],{"name":115,"role":35,"phone":116,"phoneExt":11,"email":117},"Prof. Dr. med Adrian Billeter","+41 61 777 73 21","adrian.billeter@clarunis.ch",{"facility":119,"status":76,"city":120,"state":11,"zip":121,"country":79,"cosmosGeoPoint":122,"geoPoint":126,"contacts":127},"Inselspital, Bern University Hospital","Bern","3010",{"type":50,"coordinates":123},[124,125],7.44744,46.94809,{"lat":125,"lon":124},[128,129],{"name":30,"role":35,"phone":11,"phoneExt":11,"email":11},{"name":30,"role":32,"phone":11,"phoneExt":11,"email":11},{"facility":131,"status":76,"city":132,"state":11,"zip":133,"country":79,"cosmosGeoPoint":134,"geoPoint":138,"contacts":139},"Department of Visceral Surgery, University Hospital Geneva","Geneva","1205",{"type":50,"coordinates":135},[136,137],6.14569,46.20222,{"lat":137,"lon":136},[140],{"name":141,"role":35,"phone":142,"phoneExt":11,"email":143},"Prof. Dr. med. Christian Toso","+41 22 372 77 02","christian.toso@hug.ch",{"facility":145,"status":76,"city":146,"state":11,"zip":147,"country":79,"cosmosGeoPoint":148,"geoPoint":152,"contacts":153},"Department of General, Visceral, Endocrine and Transplantation Surgery, Kantonsspital St. Gallen","Sankt Gallen","9000",{"type":50,"coordinates":149},[150,151],9.37477,47.42391,{"lat":151,"lon":150},[154],{"name":155,"role":35,"phone":156,"phoneExt":11,"email":157},"PD Dr. med. Ignazio Tarantino","+41 71 494 13 12","ignazio.tarantino@h-och.ch",{"facility":159,"status":76,"city":160,"state":11,"zip":161,"country":79,"cosmosGeoPoint":162,"geoPoint":166,"contacts":167},"Department of Surgery, Stadtspital Triemli Zürich","Zurich","8063",{"type":50,"coordinates":163},[164,165],8.55,47.36667,{"lat":165,"lon":164},[168],{"name":169,"role":35,"phone":170,"phoneExt":11,"email":171},"Dr. med. Stefan Gutknecht","+41 44 416 43 61","stefan.gutknecht@stadtspital.ch",{"facility":173,"status":76,"city":160,"state":11,"zip":174,"country":79,"cosmosGeoPoint":175,"geoPoint":177,"contacts":178},"Department of Surgery and Transplantation, University Hospital Zürich","8091",{"type":50,"coordinates":176},[164,165],{"lat":165,"lon":164},[179],{"name":180,"role":35,"phone":181,"phoneExt":11,"email":182},"Prof. Dr. med. José Oberholzer","+41 44 255 33 00","jose.oberholzer@usz.ch",{"type":184,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100577715",false,"NCT06801899","ToPanc Trial: Survival After Total Versus Partial Pancreaticoduodenectomy for Adenocarcinoma of the Pancreatic Head, Distal Cholangiocarcinoma, and Ampullary Cancer","ToPanc Trial: Survival After Total Versus Partial Pancreaticoduodenectomy for Adenocarcinoma of the Pancreatic Head, Distal Cholangiocarcinoma, and Ampullary Cancer: a Multi-centric Randomized Controlled Trial","ToPanc","Inclusion Criteria:\n\n* Adult patients (age ≥ 18 years) scheduled to undergo PD for highly suspected or histologically proven, resectable pancreatic ductal adenocarcinoma (PDAC), distal cholangiocarcinoma (DCC), and\u002For ampullary cancer (pancreaticobiliary type)\n* Suspected pancreas anastomosis at high-risk for development of a postoperative pancreatic fistula (POPF) (grade \"D\" according to Schuh et al. (29): Estimation by CT scan, MRI, and\u002For Endoscopic Ultrasound\n* Written informed consent\n\nExclusion Criteria:\n\n* Duodenal carcinoma, ampullary cancer (intestinal type), neuroendocrine tumors, benign tumors, chronic pancreatitis\n* Medical conditions that do not allow appreciation of the nature, scope, and possible consequences of the trial as judged by the investigator\n* Pregnancy. A beta-Human Chorionic Gonadotropin (bHCG) pregnancy test must to be performed for women of child-bearing potential (defined as premenopausal women who have not undergone surgical sterilization)\n* Inability to follow the study procedures, e.g., due to psychological disorders, dementia, etc.","ALL","18 Years",{"count":195,"type":196},170,"ESTIMATED","INTERVENTIONAL",[199],"NA","The goal of this clinical trial is to learn if total removal of the pancreas is a preferable alternative to partial removal in patients with cancer of the pancreatic head who are at high risk of pancreatic leakage. The main question it aims to answer is:\n\nDoes total pancreas removal improve survival without reducing quality of life compared to partial removal?\n\nThe only study specific procedures are the collection of 2 blood samples (7.5ml for each time point, preoperatively and during the hospitalisation) and the completion of the questionnaires.",[202],"Pancreatic Cancer","2026-06-18",{"date":205,"type":206},"2026-06-23","ACTUAL",{"date":208,"type":206},"2026-06-01",{"date":210,"type":196},"2030-10",{"name":5,"class":6},10]