[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100547327":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":33,"centralContacts":38,"locations":47,"responsibleParty":64,"collaborators":42,"id":68,"slug":42,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":22,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":42,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":85,"overallStatus":49,"whyStopped":42,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"University of Giessen","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"PRF site (test site)","EXPERIMENTAL","The participants become at least two teeth removed, one site is applied with PRF (test site) while the other is left for natural healing by forming a blood clot (control site). Operator and Investigator as well as the Patient are blinded to to the site of application.",[13],"Procedure: PRF",{"label":15,"type":16,"description":11,"interventionNames":17},"Blood clot (control site)","ACTIVE_COMPARATOR",[18],"Procedure: Natural Healing",[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","PRF","Patients blood is standardized centrifuged and split in to a red-phase (erythrocytes) and white-phase (PRF). The gained PRF is processed to a clot-fort and is inserted into the alveolus.",[9],[26],"Platelet rich fibrin",{"type":21,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Natural Healing","After the tooth extraction, natural healing is aimed by allowing a blood clot formation without any further intervention.",[15],[32],"Blood clot formation",[34],{"name":35,"affiliation":36,"role":37},"Sameh Attia, DDS, MSc","UKGM","STUDY_DIRECTOR",[39,44],{"name":35,"role":40,"phone":41,"phoneExt":42,"email":43},"CONTACT","‭(+49) 641 9946112‬",null,"Sameh.Attia@dentist.med.uni-giessen.de",{"name":45,"role":40,"phone":41,"phoneExt":42,"email":46},"Jan Nuernberg, DDS","jan.nuernberg@uk-gm.de",[48],{"facility":5,"status":49,"city":50,"state":51,"zip":42,"country":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"RECRUITING","Giessen","Hesse","Germany",{"type":54,"coordinates":55},"Point",[56,57],8.67554,50.58727,{"lat":57,"lon":56},[60],{"name":61,"role":40,"phone":62,"phoneExt":42,"email":63},"Sameh Attia, MSc","+49 176 80732647","Sameh.Attia@dentist.med.uni-gie",{"type":65,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":42,"oldOrganization":42},"PRINCIPAL_INVESTIGATOR","Sameh Attia","Senior Physician in the department of Oral and Maxillofacial Surgery,PD, Dr. med. dent., M.Sc.","100547327",false,"NCT06406530","Topical Application of PRF Before Radiation Therapy","Topical Application of PRF in Tooth Extraction Sockets Before Radiation Therapy for Head and Neck Cancer","Inclusion Criteria:\n\n* Head and neck cancer with planed radiation therapy\n* Bilateral tooth extraction\n* Similar tooth size\n* Atraumatic tooth extractions without flap surgery\n* Patients age above 18y of age\n\nExclusion Criteria:\n\n* Prior radiation therapy in the head and neck area\n* Prior and current therapy with bisphosphonates or equivalent modern biologics\n* Patients during pregnancy or breastfeeding","ALL","18 Years","99 Years",{"count":78,"type":79},34,"ESTIMATED","INTERVENTIONAL",[82],"NA","The primary goal of this study is to observe whether PRP promotes the wound healing before a radiation therapy or not, compared to the natural healing of a tooth extraction socket.\n\nSecondary aim is to monitore the effect on the pain perception.",[22],[22,86,87,88,89,90],"wound healing","dentistry","oral surgery","radiation therapy","cancer","2025-04-08",{"date":93,"type":94},"2025-04-11","ACTUAL",{"date":96,"type":94},"2023-12-01",{"date":98,"type":79},"2025-09-01",{"name":5,"class":6},1]