[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100424777":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":49,"centralContacts":53,"locations":63,"responsibleParty":78,"collaborators":48,"id":82,"slug":48,"hasResults":83,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":48,"eligibilityCriteria":87,"healthyVolunteers":83,"sex":88,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":48,"studyType":94,"phases":95,"briefSummary":97,"conditions":98,"keywords":48,"overallStatus":65,"whyStopped":48,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"Assiut University","OTHER",[8,14,19,23],{"label":9,"type":10,"description":11,"interventionNames":12},"T group","ACTIVE_COMPARATOR","each participant will receive 15 mg\u002Fkg of tranexamic acid diluted in a 10 mL syringe slowly over 10-15 minutes, 15 minutes before skin incision.",[13],"Drug: Tranexamic acid",{"label":15,"type":10,"description":16,"interventionNames":17},"TC group","each participant will receive 10 mg\u002Fkg of tranexamic acid diluted in a 5 mL syringe slowly over 5 minutes, 15 minutes before skin incision, and A caudal epidural block with 1 mL\u002Fkg of 0.25% bupivacaine.",[13,18],"Procedure: caudal epidural block",{"label":20,"type":10,"description":21,"interventionNames":22},"C group","each participant will receive a caudal epidural block with 1 mL\u002Fkg of 0.25% bupivacaine.",[18],{"label":24,"type":25,"description":26,"interventionNames":27},"P group","PLACEBO_COMPARATOR","participants will receive the regular standard care without adding tranexamic acid or caudal epidural block",[28],"Other: Placebo",[30,37,44],{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"DRUG","Tranexamic acid","patients treated with TXA will have reduced blood loss and transfusion requirements compared with those who did not receive TXA",[9,15],[36],"Kapron",{"type":38,"name":39,"description":40,"armGroupLabels":41,"otherNames":42},"PROCEDURE","caudal epidural block","regional anesthesia in orthopedic procedures are known to help reduction of intraoperative blood loss",[20,15],[43],"bupivacaine 0.25%",{"type":6,"name":45,"description":46,"armGroupLabels":47,"otherNames":48},"Placebo","participants will receive standard care but neither TXA nor caudal epidural block",[24],null,[50],{"name":51,"affiliation":5,"role":52},"Amr M Sleem, M.D.","STUDY_DIRECTOR",[54,59],{"name":55,"role":56,"phone":57,"phoneExt":48,"email":58},"Shimaa A Hassan, M.D.","CONTACT","01002953253","shimaa.abbas@med.aun.edu.eg",{"name":60,"role":56,"phone":61,"phoneExt":48,"email":62},"Amira A Abdel-rahman, M.B.B.CH","01002595850","amiraali441994@gmail.com",[64],{"facility":5,"status":65,"city":66,"state":48,"zip":67,"country":68,"cosmosGeoPoint":69,"geoPoint":74,"contacts":75},"RECRUITING","Asyut","71515","Egypt",{"type":70,"coordinates":71},"Point",[72,73],31.18368,27.18096,{"lat":73,"lon":72},[76],{"name":77,"role":56,"phone":57,"phoneExt":48,"email":58},"Shimaa A Hassan, MD",{"type":79,"investigatorFullName":80,"investigatorTitle":81,"investigatorAffiliation":5,"oldNameTitle":48,"oldOrganization":48},"PRINCIPAL_INVESTIGATOR","Shimaa Abbas Hassan","lectrure of Anesthesia","100424777",false,"NCT04811313","Tranexamic Acid in Pediatric Undergoing Proximal Femoral Osteotomies and\u002For Acetabular Osteotomy","Impact of Tranexamic Acid Use on Blood Loss and Transfusion Rates After Hip Reconstruction in Children, A Randomized Controlled Trial","Inclusion Criteria:\n\n* ASA I - II\n* Scheduled for acetabular osteotomy and\u002For proximal femoral derotation osteotomies.\n\nExclusion Criteria:\n\n* Patient's guardian refusal to participate in the study.\n* Children known to have pre-existing bleeding or coagulation disorders.\n* Children with anemia; defined according to (WHO ) cutoffs as Hb level\\\u003C11g\u002Fdl for girls and \\\u003C12g\u002Fdl for boys\n* History of epilepsy.\n* History of renal insufficiency or failure","ALL","1 Year","18 Years",{"count":92,"type":93},400,"ESTIMATED","INTERVENTIONAL",[96],"NA","Surgical hip reconstruction reduces the hip joint through soft tissue releases and osteotomies of the femur and\u002For pelvis. Blood loss and subsequent blood transfusion are normal consequences of hip reconstruction.",[99,100,101],"Intraoperative Blood Loss","Pediatric","Orthopedic Disorder","2025-11-14",{"date":104,"type":105},"2025-11-17","ACTUAL",{"date":107,"type":105},"2025-04-03",{"date":109,"type":93},"2026-03",{"name":5,"class":6},1]