[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637499":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":41,"responsibleParty":58,"collaborators":26,"id":60,"slug":26,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":26,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":26,"enrollmentInfo":68,"targetDuration":26,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":78,"overallStatus":84,"whyStopped":26,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active taVNS","EXPERIMENTAL","Participants receive active transcutaneous auricular vagus nerve stimulation delivered via the cymba conchae of the left ear using the using the tVNS R device (taVNS Technologies, Erlangen, Germany) for 4 hours per day for 30 days.",[13],"Device: Active Transcutaneous Auricular Vagus Nerve Stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham taVNS","SHAM_COMPARATOR","Stimulation will target the ear lobe using the tVNS R device (taVNS Technologies, Erlangen, Germany) for 4 hours per day for 30 days. Stimulation will be applied to the ear lobe in order to ensure participant feel the stimulation while avoiding activation of the vagus nerve.",[19],"Device: Sham Transcutaneous Auricular Vagus Nerve Stimulation",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Active Transcutaneous Auricular Vagus Nerve Stimulation","Stimulation will target the auricular branch of the vagus nerve by applying stimulation to the cymba conchae region of the ear using the tVNS R device (taVNS Technologies, Erlangen, Germany). To achieve adequate stimulation while avoiding unpleasant or painful sensations, the stimulation intensity will be gradually increased in increments of 0.1mA (milliamps) until the subjective pain threshold is reached, and then reduced to a stimulus intensity just below the individuals pain threshold (expected range based on prior studies 1 - 3.2mA). Pulse width will be set at 100μs (microseconds) and frequency will be set at 25Hz (Hertz). Parameters will be set for the duration of the intervention consisting of 4 hours of daily stimulation for a period of 30 days.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Sham Transcutaneous Auricular Vagus Nerve Stimulation","Stimulation will target the ear lobe using the tVNS R device (taVNS Technologies, Erlangen, Germany). To achieve adequate stimulation while avoiding unpleasant or painful sensations, the stimulation intensity will be gradually increased in increments of 0.1mA until the subjective pain threshold is reached, and then reduced to a stimulus intensity just below the individuals pain threshold (expected range based on prior studies 1 - 3.2mA). Pulse width will be set at 100μs and frequency will be set at 25Hz. Participants will perform 4 hours of stimulation per day for a period of 30 days. Stimulation will be applied to the ear lobe in order to ensure participant feel the stimulation while avoiding activation of the vagus nerve.",[15],[32,38],{"name":33,"role":34,"phone":35,"phoneExt":36,"email":37},"David J Allison, PhD.","CONTACT","519 646 6100","42570","David.Allison@sjhc.london.on.ca",{"name":39,"role":34,"phone":35,"phoneExt":36,"email":40},"Joy Jiang","fjiang63@uwo.ca",[42],{"facility":43,"status":26,"city":44,"state":45,"zip":46,"country":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Parkwood Institute, St Joseph's Health Care London","London","Ontario","N6C0A7","Canada",{"type":49,"coordinates":50},"Point",[51,52],-81.23304,42.98339,{"lat":52,"lon":51},[55,57],{"name":56,"role":34,"phone":35,"phoneExt":36,"email":37},"David J. Allison, PhD",{"name":39,"role":34,"phone":35,"phoneExt":36,"email":40},{"type":59,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100637499",false,"NCT07588711","Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Neuropathic Pain Following Spinal Cord Injury","Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) as an Anti-inflammatory Strategy for the Treatment of Neuropathic Pain Following Spinal Cord Injury","Inclusion Criteria:\n\n* SCI of any level or severity\n* 18 years of age or older\n* current neuropathic pain\n* on no medications or on a stable prescribed dose (no change in prior 6-weeks) of anti-inflammatory, pain medications and\u002For depression medications\n\nExclusion Criteria:\n\n* Prone to autonomic dysreflexia\n* presence of cardiovascular disease\n* pacemaker or other implanted electrical device\n* cerebral shunts\n* epilepsy\n* pregnant or attempting to become pregnant\n* current wound\u002Finfection\n* unstable dose of prescribed anti-inflammatory, depression, or pain medications within past 6-weeks.","ALL","18 Years",{"count":69,"type":70},32,"ESTIMATED","INTERVENTIONAL",[73],"NA","This pilot randomized, double-blind, sham-controlled clinical investigation will evaluate the feasibility and safety of a 30-day home-based transcutaneous auricular vagus nerve stimulation (taVNS) intervention in adults with spinal cord injury (SCI) and neuropathic pain. Participants will be randomized to receive either active taVNS targeting the auricular branch of the vagus nerve or sham taVNS delivered to the earlobe. Primary outcomes include feasibility, safety, adherence, acceptability, and blinding success. Exploratory outcomes include changes in neuropathic pain, systemic inflammatory biomarkers, vagal tone assessed via heart rate variability, and quality of life.",[76,77],"Spinal Cord Injury","Neuropathic Pain",[79,80,81,82,83],"vagus nerve stimulation","inflammation","spinal cord injury","neuropathic pain","taVNS","NOT_YET_RECRUITING","2026-05-07",{"date":87,"type":88},"2026-05-15","ACTUAL",{"date":90,"type":70},"2026-10-01",{"date":92,"type":70},"2028-08-30",{"name":5,"class":6},1]