[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100356729":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":36,"centralContacts":40,"locations":48,"responsibleParty":72,"collaborators":76,"id":83,"slug":20,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":84,"sex":89,"minAge":90,"maxAge":20,"enrollmentInfo":91,"targetDuration":20,"studyType":94,"phases":95,"briefSummary":97,"conditions":98,"keywords":102,"overallStatus":51,"whyStopped":20,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":120},{"fullName":5,"class":6},"Leiden University Medical Center","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Transforaminal Epidural Injection","EXPERIMENTAL","Transforaminal Epidural Injection containing 1,5 mL lidocaine 2% and 40mg methylprednisolone acetate for injections L3 or below Transforaminal Epidural Injection containing 1,5 mL lidocaine 1% and 10mg dexamethasone for injections above L3",[13,14,15],"Drug: Lidocaine","Drug: Methylprednisolone Acetate","Drug: Dexamethasone",{"label":17,"type":18,"description":19,"interventionNames":20},"Oral pain medication","NO_INTERVENTION","Patients will receive oral pain medication according to general practitioner guidelines.",null,[22,27,33],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":20},"DRUG","Lidocaine","In combination with dexamethasone or methylprednisolone acetate",[9],{"type":23,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Methylprednisolone Acetate","In combination with lidocaine",[9],[32],"Depo-Medrol",{"type":23,"name":34,"description":29,"armGroupLabels":35,"otherNames":20},"Dexamethasone",[9],[37],{"name":38,"affiliation":5,"role":39},"Carmen LA Vleggeert-Lankamp, MD Msc Ph.D","PRINCIPAL_INVESTIGATOR",[41,45],{"name":38,"role":42,"phone":43,"phoneExt":20,"email":44},"CONTACT","+31715262109","cvleggeert@lumc.nl",{"name":46,"role":42,"phone":43,"phoneExt":20,"email":47},"Eduard JA Verheijen, Bsc","e.j.a.verheijen@lumc.nl",[49,63],{"facility":50,"status":51,"city":52,"state":20,"zip":20,"country":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Spaarne Gasthuis","RECRUITING","Haarlem","Netherlands",{"type":55,"coordinates":56},"Point",[57,58],4.63683,52.38084,{"lat":58,"lon":57},[61],{"name":62,"role":42,"phone":20,"phoneExt":20,"email":20},"Carmen Vleggeert-Lankamp, M.D. Ph.D",{"facility":50,"status":51,"city":64,"state":20,"zip":20,"country":53,"cosmosGeoPoint":65,"geoPoint":69,"contacts":70},"Hoofddorp",{"type":55,"coordinates":66},[67,68],4.68889,52.3025,{"lat":68,"lon":67},[71],{"name":62,"role":42,"phone":20,"phoneExt":20,"email":20},{"type":73,"investigatorFullName":74,"investigatorTitle":75,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"SPONSOR_INVESTIGATOR","C.L.A.Vleggeert-Lankamp","Dr. C.L.A. Vleggeert-Lankamp",[77,78,80],{"name":50,"class":6},{"name":79,"class":6},"Stichting Achmea Gezondheidszor",{"name":81,"class":82},"Posthumus Meyjes Fonds","UNKNOWN","100356729",false,"NCT03924791","Transforaminal Epidural Injection in Acute Sciatica","TEIAS","Inclusion Criteria:\n\n* Diagnosed with sciatica by GP\n* NRS leg pain of 6 or more on a 10-point NRS scale\n* Minimum duration of symptoms of 3 weeks and maximum duration of 8 weeks\n\nExclusion Criteria:\n\n* Age under 18 years\n* Condition preventing to receive transforaminal epidural injection\n* Severe scoliosis\n* Transforaminal epidural injection received in 6 months before randomization date\n* Surgery for sciatica at the same level\n* Surgery for sciatica at another level within one year before inclusion\n* Pregnancy","ALL","18 Years",{"count":92,"type":93},142,"ESTIMATED","INTERVENTIONAL",[96],"NA","Patients suffering from sciatica are treated conservatively for the first 8 weeks due to the favourable prognosis. This period is preferably extended up to 14-16 weeks after which patients may opt for surgery. However, patients may experience severe discomfort due to pain in the leg which can lead to decreased physical activity and socio-economic problems. An adequate therapy to alleviate symptoms during this period of 'wait-and-see' is lacking. In this study, patients will be randomized to treatment with transforaminal epidural injections or standard oral pain medication.",[99,100,101],"Sciatica","Sciatica Due to Intervertebral Disc Disorder","Sciatic Radiculopathy",[99,103,104,105,106,107,108,109,110],"Acute sciatica","Transforaminal epidural injection","Leg pain","Lumbar spine","Back pain","Lumbar surgery","Herniated intervertebral lumbar disk","Cost-effectiveness","2023-10-18",{"date":113,"type":114},"2023-10-19","ACTUAL",{"date":116,"type":114},"2019-06-01",{"date":118,"type":93},"2026-07",{"name":74,"class":6},2]