Health Trials

Transfusion Requirements in Younger Patients Undergoing Cardiac Surgery

ConditionsDisorderHeartPostoperativeCardiac Surgery
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorUnity Health Toronto

About this trial

TRICS-IV is an international, multi-centre, open-label randomized controlled trial of two commonly used transfusion strategies in moderate to high risk patients who are 65 years of age or younger undergoing cardiac surgery on cardiopulmonary bypass, using a superiority trial design.

Eligibility criteria

Qualifiers

≥18 and ≤65 years of age

Planned cardiac surgery using cardiopulmonary bypass

Informed consent obtained

Preoperative European System for Cardiac Operative Risk Evaluation (EuroSCORE I) of 6 or more

Disqualifiers

Patients who refuse participation

Patients who are unable to receive or who refuse blood products

Patients who are involved in a preoperative autologous pre-donation program

Patients who are having a heart transplant or having surgery solely for an insertion of a ventricular assist device

Trial design

Treatments tested in this trial

  • Restrictive Transfusion Strategy
  • Liberal transfusion strategy

Treatment groups

1,440 Participants
are divided into 2 treatment groups

Locations

54
Australia
Royal Adelaide Hospital5000, AdelaideAdelaide, Australia
Royal Prince Alfred hospital2050, CamperdownNew South Wales, Australia
Prince of Wales Hospital2024, RandwickNew South Wales, Australia
Westmead Hospital2145, WestmeadNew South Wales, Australia

Sponsors and collaborators

Unity Health Toronto

Lead sponsor

Source ClinicalTrials.gov