[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577582":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":11,"centralContacts":27,"locations":33,"responsibleParty":79,"collaborators":11,"id":83,"slug":11,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":84,"sex":89,"minAge":90,"maxAge":91,"enrollmentInfo":92,"targetDuration":11,"studyType":95,"phases":96,"briefSummary":98,"conditions":99,"keywords":103,"overallStatus":36,"whyStopped":11,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":114},{"fullName":5,"class":6},"Lo.Li.Pharma s.r.l","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Treated Group HP+phD","EXPERIMENTAL",null,[13],"Dietary Supplement: myo-Inositol plus DIoscorea Villosa",{"label":15,"type":16,"description":17,"interventionNames":11},"Controls","NO_INTERVENTION","Not treated patients",[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DIETARY_SUPPLEMENT","myo-Inositol plus DIoscorea Villosa","myo-Inositol + alpha-lactalbumin + folic acid once daily, Dioscorea Villosa + alpha-lactalbumin + Vitamin D twice daily",[9],[25,26],"myo-Inositol","Dioscorea Villosa",[28],{"name":29,"role":30,"phone":31,"phoneExt":11,"email":32},"Vittorio Unfer","CONTACT","(+39)06\u002F22442074","vunfer@gmail.com",[34,51,64],{"facility":35,"status":36,"city":37,"state":38,"zip":39,"country":38,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Zhordania and Khomasuridze Institute of Reproductology","RECRUITING","Tbilisi","Georgia","0112",{"type":41,"coordinates":42},"Point",[43,44],44.83412,41.69143,{"lat":44,"lon":43},[47],{"name":48,"role":30,"phone":49,"phoneExt":11,"email":50},"Lali Pkhaladze","+995 599 58 41 09","lpkhaladze@yahoo.com",{"facility":52,"status":36,"city":53,"state":54,"zip":55,"country":54,"cosmosGeoPoint":56,"geoPoint":60,"contacts":61},"Agunco","Rome","Italy","00155",{"type":41,"coordinates":57},[58,59],12.51133,41.89193,{"lat":59,"lon":58},[62],{"name":29,"role":30,"phone":63,"phoneExt":11,"email":32},"06 4050 0651",{"facility":65,"status":36,"city":66,"state":67,"zip":11,"country":68,"cosmosGeoPoint":69,"geoPoint":73,"contacts":74},"Department of Obstetrics and Gynecology with Reproductive Medicine, F.I. Inozemtsev Academy of Medical Education","Saint Petersburg","Russian Federation","Russia",{"type":41,"coordinates":70},[71,72],30.31413,59.93863,{"lat":72,"lon":71},[75],{"name":76,"role":30,"phone":77,"phoneExt":11,"email":78},"Olga Pustotina","8 (916) 926 76 52","pustotina@gmail.com",{"type":80,"investigatorFullName":29,"investigatorTitle":81,"investigatorAffiliation":82,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Professor","AGUNCO Obstetrics and Gynecology Centre","100577582",false,"NCT06800170","Treatment of Menstrual Cycle Alterations in Adolescents","HP-phD_Adolesc","Inclusion Criteria:\n\n* adolescent women aged 14-19 years old, with at least 3 years passed after menarche, and oligomenorrhea or amenorrhea\n\nExclusion Criteria:\n\n* Primary amenorrhea.\n* Hyperandrogenism due to other factors (i.e. adrenal hyperplasia or Cushing syndrome).\n* Hyperprolactinemia or overt hypothyroidism (TSH ≥4).\n* Other hormonal alterations.\n* Ongoing hormonal therapies, including OCPs, six months before enrollment.\n* Ongoing pharmacological therapies.\n* Ongoing use of myo-Inositol supplement or other source of myo-Inositol, or Dioscorea villosa, six months before enrollment.","FEMALE","14 Years","19 Years",{"count":93,"type":94},20,"ESTIMATED","INTERVENTIONAL",[97],"NA","the aim of the present study is intended to evaluate how treatment with Myo-Inositol and Dioscorea Villosa can help improve menstrual cycle irregularities in adolescents, both with and without PCOS.",[100,101,102],"Amenorrhea","Oligomenorrhea","PCOS (Polycystic Ovary Syndrome)",[25,26,104],"adolescents","2026-01-05",{"date":107,"type":108},"2026-01-06","ACTUAL",{"date":110,"type":108},"2025-06-01",{"date":112,"type":94},"2026-12",{"name":5,"class":6},3]