[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100416837":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":30,"centralContacts":35,"locations":45,"responsibleParty":244,"collaborators":246,"id":253,"slug":10,"hasResults":254,"nctId":255,"briefTitle":256,"officialTitle":257,"acronym":10,"eligibilityCriteria":258,"healthyVolunteers":254,"sex":259,"minAge":10,"maxAge":10,"enrollmentInfo":260,"targetDuration":10,"studyType":263,"phases":10,"briefSummary":264,"conditions":265,"keywords":267,"overallStatus":48,"whyStopped":10,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":272,"startDateStruct":275,"completionDateStruct":277,"leadSponsor":279,"locationsCount":280},{"fullName":5,"class":6},"University of Alberta","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Heart transplant protocol and for cause biopsies",null,"The study population includes patients with a functioning heart transplant undergoing a biopsy for clinical indications as standard of care, or protocol biopsies of heart in high-risk patients, or follow-up after treatment.",[13,14,15],"Diagnostic Test: MMDx diagnostic test","Diagnostic Test: Prospera","Diagnostic Test: HLA antibody",[17,22,26],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":10},"DIAGNOSTIC_TEST","MMDx diagnostic test","Microarray test of gene expression in heart biopsies",[9],{"type":18,"name":23,"description":24,"armGroupLabels":25,"otherNames":10},"Prospera","Donor derived cell-free DNA in patient blood",[9],{"type":18,"name":27,"description":28,"armGroupLabels":29,"otherNames":10},"HLA antibody","Centralized measurement of HLA antibodies in patient blood",[9],[31],{"name":32,"affiliation":33,"role":34},"Philip F Halloran, MD PhD","Alberta Transplant Applied Genomics Center, University of Alberta","PRINCIPAL_INVESTIGATOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":10,"email":40},"Konrad Famulski, PhD","CONTACT","1 780 782 9463","konrad@ualberta.ca",{"name":42,"role":38,"phone":43,"phoneExt":10,"email":44},"Robert Polakowski, PhD","1 780 492 5091","polakows@ualberta.ca",[46,65,81,97,116,132,148,165,181,197,213,229],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Baptist Health Institute for Research and Innovation","RECRUITING","Little Rock","Arkansas","72205","United States",{"type":54,"coordinates":55},"Point",[56,57],-92.28959,34.74648,{"lat":57,"lon":56},[60,63],{"name":61,"role":38,"phone":10,"phoneExt":10,"email":62},"Victoria McIntosh Marren","victoria.mcintosh@baptist-health.org",{"name":64,"role":34,"phone":10,"phoneExt":10,"email":10},"Patrick Campbell, MD",{"facility":66,"status":48,"city":67,"state":68,"zip":69,"country":52,"cosmosGeoPoint":70,"geoPoint":74,"contacts":75},"Tampa General Hospital, 409 Bayshore Blvd.","Tampa","Florida","33606",{"type":54,"coordinates":71},[72,73],-82.45843,27.94752,{"lat":73,"lon":72},[76,79],{"name":77,"role":38,"phone":10,"phoneExt":10,"email":78},"Kristyn Kuzianik","kkuzianik@tgh.org",{"name":80,"role":34,"phone":10,"phoneExt":10,"email":10},"Benjamin Mackie, MD",{"facility":82,"status":48,"city":83,"state":84,"zip":85,"country":52,"cosmosGeoPoint":86,"geoPoint":90,"contacts":91},"Columbia University Medical Center, Columbia Interventional Cardiovascular Care","West New York","New Jersey","10032",{"type":54,"coordinates":87},[88,89],-74.01431,40.78788,{"lat":89,"lon":88},[92,95],{"name":93,"role":38,"phone":10,"phoneExt":10,"email":94},"Maria Alejandra Muñoz Cifuentes","mam2649@cumc.columbia.edu",{"name":96,"role":34,"phone":10,"phoneExt":10,"email":10},"Gabriel Sayer, MD",{"facility":98,"status":48,"city":99,"state":100,"zip":101,"country":52,"cosmosGeoPoint":102,"geoPoint":106,"contacts":107},"Montefiore Medical Center, 3319 Rochambeau Avenue, 2nd FL","The Bronx","New York","10467",{"type":54,"coordinates":103},[104,105],-73.86641,40.84985,{"lat":105,"lon":104},[108,111,114],{"name":109,"role":38,"phone":10,"phoneExt":10,"email":110},"Renae Robinson","rerobins@montefiore.org",{"name":112,"role":38,"phone":10,"phoneExt":10,"email":113},"Brandon Johnson","brajohnson@montefiore.org",{"name":115,"role":34,"phone":10,"phoneExt":10,"email":10},"Omar Saeed, MD",{"facility":117,"status":48,"city":118,"state":119,"zip":120,"country":52,"cosmosGeoPoint":121,"geoPoint":125,"contacts":126},"Annette C. and Harold C. Simmons Transplant Institute, BaylorScott&White Research Institute","Dallas","Texas","75246",{"type":54,"coordinates":122},[123,124],-96.80667,32.78306,{"lat":124,"lon":123},[127,130],{"name":128,"role":38,"phone":10,"phoneExt":10,"email":129},"Aayla K Jamil, MBBS","Aayla.Jamil@BSWHealth.org",{"name":131,"role":34,"phone":10,"phoneExt":10,"email":10},"Shelley Hall, MD",{"facility":133,"status":48,"city":134,"state":135,"zip":136,"country":52,"cosmosGeoPoint":137,"geoPoint":141,"contacts":142},"Cardiovascular Medicine, University of Utah Health","Salt Lake City","Utah","84132",{"type":54,"coordinates":138},[139,140],-111.89105,40.76078,{"lat":140,"lon":139},[143,146],{"name":144,"role":38,"phone":10,"phoneExt":10,"email":145},"Jennifer Hong","Jennifer.Hong@hsc.utah.edu",{"name":147,"role":34,"phone":10,"phoneExt":10,"email":10},"Josef Stehlik, MD, PhD",{"facility":149,"status":150,"city":151,"state":10,"zip":152,"country":153,"cosmosGeoPoint":154,"geoPoint":158,"contacts":159},"Cardiac Transplantation Laboratory, The Victor Chang Cardiac Research Institute","NOT_YET_RECRUITING","Darlinghurst","NSW 2010","Australia",{"type":54,"coordinates":155},[156,157],151.21925,-33.87939,{"lat":157,"lon":156},[160,163],{"name":161,"role":38,"phone":10,"phoneExt":10,"email":162},"Carmen Herrera, MD","peter.macdonal@svha.org.au",{"name":164,"role":34,"phone":10,"phoneExt":10,"email":10},"Peter MacDonald, MD",{"facility":166,"status":48,"city":167,"state":168,"zip":169,"country":170,"cosmosGeoPoint":171,"geoPoint":175,"contacts":176},"Division of Cardiology, University of Alberta","Edmonton","Alberta","T6G 2R7","Canada",{"type":54,"coordinates":172},[173,174],-113.46871,53.55014,{"lat":174,"lon":173},[177,180],{"name":178,"role":38,"phone":10,"phoneExt":10,"email":179},"Daniel Kim, MD","dk@ualberta.ca",{"name":178,"role":34,"phone":10,"phoneExt":10,"email":10},{"facility":182,"status":48,"city":183,"state":10,"zip":184,"country":185,"cosmosGeoPoint":186,"geoPoint":190,"contacts":191},"Institute for Clinical and Experimental Medicine - IKEM Videnska 1958\u002F9","Prague","140 21","Czechia",{"type":54,"coordinates":187},[188,189],14.42076,50.08804,{"lat":189,"lon":188},[192,195],{"name":193,"role":38,"phone":10,"phoneExt":10,"email":194},"Tereza Novakowa","novt@ikem.cz",{"name":196,"role":34,"phone":10,"phoneExt":10,"email":10},"Vojtech Melenovsky, MD PhD",{"facility":198,"status":150,"city":199,"state":10,"zip":200,"country":201,"cosmosGeoPoint":202,"geoPoint":206,"contacts":207},"Heart Failure and Heart Transplant Unit, University of Bologna","Bologna","40138","Italy",{"type":54,"coordinates":203},[204,205],11.33875,44.49381,{"lat":205,"lon":204},[208,211],{"name":209,"role":38,"phone":10,"phoneExt":10,"email":210},"Laura Borgese","laura.borgese@gmail.com",{"name":212,"role":34,"phone":10,"phoneExt":10,"email":10},"Luciano Potena, MD",{"facility":214,"status":48,"city":215,"state":10,"zip":216,"country":217,"cosmosGeoPoint":218,"geoPoint":222,"contacts":223},"Silesian Center for Heart Diseases (Ś!ąskie Centrum Chorób Serca w Zabrzu","Zabrze","41-800","Poland",{"type":54,"coordinates":219},[220,221],18.78576,50.32492,{"lat":221,"lon":220},[224,227],{"name":225,"role":38,"phone":10,"phoneExt":10,"email":226},"Agnieszka Kuczaj, MD PhD","agnieszka.kuczaj@gmail.com",{"name":228,"role":34,"phone":10,"phoneExt":10,"email":10},"Piotr Przybylowski, Professor",{"facility":230,"status":150,"city":231,"state":10,"zip":10,"country":232,"cosmosGeoPoint":233,"geoPoint":237,"contacts":238},"Advanced Heart Failure Transplant Unit","A Coruña","Spain",{"type":54,"coordinates":234},[235,236],-8.396,43.37135,{"lat":236,"lon":235},[239,242],{"name":240,"role":38,"phone":10,"phoneExt":10,"email":241},"Zulaika Grille Cancela","Zulaika.grille.cancela@sergas.es",{"name":243,"role":34,"phone":10,"phoneExt":10,"email":10},"Maria G Crespo-Leiro, MD",{"type":245,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[247,250],{"name":248,"class":249},"Natera, Inc.","INDUSTRY",{"name":251,"class":252},"One Lambda","UNKNOWN","100416837",false,"NCT04707872","Trifecta-Heart cfDNA-MMDx Study","Trifecta-Heart cfDNA-MMDX Study: Comparing the DD-cfDNA Test to MMDx Microarray Test and Central HLA Antibody Test","Inclusion Criteria:\n\n* All heart transplant recipients undergoing a biopsy for clinical indications and protocol biopsies, as determined by their physician or surgeon, will be eligible to enroll in the study.\n* Patients are enrolled based on standard of care biopsies, including surveillance biopsies in high-risk patients, with informed consent.\n\nExclusion Criteria:\n\n* Patients will be excluded from the study if they decline participation\n* Are unable to give informed consent.\n* Recipients of multiple organs.","ALL",{"count":261,"type":262},300,"ESTIMATED","OBSERVATIONAL","Demonstrate the relationship between DD-cfDNA levels and HLA antibodies in blood transplant recipient and the Molecular Microscope® (MMDx) Diagnostic System results in indication and protocol biopsies from heart transplants.",[266],"Heart Transplant Rejection",[268,269,270],"Donor derived cfDNA","gene expression","heart transplant biopsy","2026-06-01",{"date":273,"type":274},"2026-06-02","ACTUAL",{"date":276,"type":274},"2021-06-01",{"date":278,"type":262},"2028-07",{"name":5,"class":6},12]