[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637978":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":37,"locations":46,"responsibleParty":91,"collaborators":95,"id":103,"slug":10,"hasResults":104,"nctId":105,"briefTitle":106,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":104,"sex":109,"minAge":110,"maxAge":111,"enrollmentInfo":112,"targetDuration":10,"studyType":115,"phases":10,"briefSummary":116,"conditions":117,"keywords":119,"overallStatus":49,"whyStopped":10,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":135},{"fullName":5,"class":6},"University Hospital of Ferrara","OTHER",[8,13,16],{"label":9,"type":10,"description":10,"interventionNames":11},"Controls",null,[12],"Diagnostic Test: Oral Fat Load Test",{"label":14,"type":10,"description":10,"interventionNames":15},"Prediabetics",[12],{"label":17,"type":10,"description":10,"interventionNames":18},"Diabetics",[12],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"DIAGNOSTIC_TEST","Oral Fat Load Test","After a 12-hour overnight fast, each participant will be given a sugar-free mascarpone cream containing 75 g of fat.\n\nBlood samples will be collected before (OFL Time -1 minute) and 1 (OFL Time +1 hour), 2 (OFL Time +2 hours), 3 (OFL Time +3 hours), 4 (OFL Time +4 hours), and 6 (OFL Time +6 hours) hours after the OFL.",[9,17,14],[26,30,34,35],{"name":27,"affiliation":28,"role":29},"Angelina Passaro, Degree in Medicine and Surgery","University Hospital of Ferrara \"Sant'Anna\"","STUDY_CHAIR",{"name":31,"affiliation":32,"role":33},"Luca Catapano, Degree in Medicine and Surgery","Azienda USL Ferrara","PRINCIPAL_INVESTIGATOR",{"name":27,"affiliation":28,"role":33},{"name":27,"affiliation":28,"role":36},"STUDY_DIRECTOR",[38,43],{"name":39,"role":40,"phone":41,"phoneExt":10,"email":42},"Fabiola Castaldo, Pharmacy","CONTACT","+39 3348330516","fabiola.castaldo@unife.it",{"name":44,"role":40,"phone":10,"phoneExt":10,"email":45},"Juana M Sanz Molina, Chemistry","szj@unife.it",[47,71],{"facility":48,"status":49,"city":50,"state":50,"zip":51,"country":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"University Hospital \"Sant'Anna\" of Ferrara","RECRUITING","Ferrara","44124","Italy",{"type":54,"coordinates":55},"Point",[56,57],11.62057,44.83804,{"lat":57,"lon":56},[60,61,64,66,67,69],{"name":39,"role":40,"phone":41,"phoneExt":10,"email":42},{"name":62,"role":63,"phone":10,"phoneExt":10,"email":10},"Juana Maria Sanz Molina, Chemistry Degree","SUB_INVESTIGATOR",{"name":65,"role":63,"phone":10,"phoneExt":10,"email":10},"Domenico Sergi, Nutritional science",{"name":27,"role":33,"phone":10,"phoneExt":10,"email":10},{"name":68,"role":63,"phone":10,"phoneExt":10,"email":10},"Edoardo Dalla Nora, Degree in Medicine and Surgery",{"name":70,"role":63,"phone":10,"phoneExt":10,"email":10},"Simona Colombari, Degree in Dietetics",{"facility":72,"status":49,"city":73,"state":50,"zip":74,"country":52,"cosmosGeoPoint":75,"geoPoint":79,"contacts":80},"Nucleo di Cure Primarie di Poggio Renatico - Medicina di Gruppo Poggio Rete Salute Via Salvo D'Acquisto, 1\u002Fa","Poggio Renatico","44023",{"type":54,"coordinates":76},[77,78],11.48695,44.76581,{"lat":78,"lon":77},[81,85,88,89],{"name":82,"role":40,"phone":83,"phoneExt":10,"email":84},"Luca Catapano, Medicine and Surgery","+39 3384838817","l.catapano@gmail.com",{"name":86,"role":40,"phone":87,"phoneExt":10,"email":10},"Eleonora Petrucci, Medicine and Surgery","+39 3461812406",{"name":31,"role":33,"phone":10,"phoneExt":10,"email":10},{"name":90,"role":63,"phone":10,"phoneExt":10,"email":10},"Eleonora Petrucci, Degree in Medicine and Surgery",{"type":92,"investigatorFullName":93,"investigatorTitle":94,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Angelina Passaro","Professor",[96,97,99,101],{"name":5,"class":6},{"name":98,"class":6},"S. Anna Hospital",{"name":32,"class":100},"OTHER_GOV",{"name":102,"class":6},"Università degli Studi di Ferrara","100637978",false,"NCT07602023","Triglyceride-rich LIPoproteins and INflammatory Cytokines After Oral FAT Loading as Potential Early Biomarkers of the Risk of Progression Towards DIABETES and Development of Complications. LIPINFAT Diabetes Study.","LIPINFAT","Inclusion Criteria:\n\n* Males and females aged 50-70 years\n* BMI between 25-30 kg\u002Fm2\n* HbA1c ≤7% for T2D\n* HbA1c ≤6.5% for prediabetes\n* HbA1c ≤5.7% for controls\n* Signed Project Information and Informed Consent Form\n* Signed Data Processing Consent Form\n\nExclusion Criteria:\n\n* Lipid-lowering therapy with ezetimibe, fenofibrate, omega-3 fatty acids, or other drugs that can interfere with lipoprotein absorption and metabolism\n* Chronic Kidney Disease (CKD) with estimated glomerular filtration rate (eGFR) \\\u003C60 ml\u002Fmin and renal impairment (e.g., uACR ≥30 mg\u002Fmmol) for 3 months or more\n* Secondary or syndromic forms of obesity\n* Patients on insulin therapy\n* All acute and chronic conditions that, in the opinion of the investigators, may cause bias.\n* Hospitalization for acute illness or major surgery in the last 6 months\n* Patients on stable therapy for less than 3 months\n* Allergy or intolerance to one or more components of the meal used in the protocol\n* Pregnancy or breastfeeding\n* Habitual consumption of alcoholic beverages (\\>20 g\u002Fday for females and \\>30 g\u002Fday for males) or unwillingness to abstain from alcoholic beverages during the study run-in period\n* All subjects who do not consent to participate in the study","ALL","50 Years","70 Years",{"count":113,"type":114},150,"ESTIMATED","OBSERVATIONAL","The aim of the study is to evaluate whether the Oral Fat Loading Test (OFLT) determines a different response in terms of the quantity, quality, and kinetics of triglyceride-rich lipoproteins in subjects with T2D, prediabetics, and control subjects, and whether triglyceride-rich lipoproteins and inflammatory cytokines after OFLT are potential early biomarkers of the risk of progression to diabetes and the development of complications in a general practice setting.\n\nTo address these questions, a hybrid cohort study was designed by identifying three groups of subjects: T2D and prediabetics (exposed and near-exposed) and control subjects (unexposed).",[118],"Prediabetes \u002F Type 2 Diabetes",[120,121,122,123,124,125],"Prediabetes, Type 2 diabetes","Oral Fat Load test","Tryglicerides","Cytokines","lipoproteins","VLDL","2026-05-14",{"date":128,"type":129},"2026-05-22","ACTUAL",{"date":131,"type":129},"2024-05-14",{"date":133,"type":114},"2028-05-14",{"name":93,"class":6},2]