TRPC6 Characterization to Predict and Prevent Chemotherapy Related Cardiomyopathy and Heart Failure With Breast Cancer
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorMayo Clinic
About this trial
This study examines TRPC6 in predicting and preventing chemotherapy related cardiac toxicity and heart failure in patients with breast cancer. Cardiac toxicity, changes in heart function is a well-recognized complication of certain cancer related therapies. Understanding these changes may allow early intervention against therapy-related cardiac toxicity and also identify novel therapeutic targets to protect patient long-term cardiac health. Studying samples of blood from patients with breast cancer in the laboratory may help doctors learn more about changes that occur in deoxyribonucleic acid (DNA), identify biomarkers related to cardiac toxicity, and prevent the development of therapy-induced cardiac toxicity in patients receiving chemotherapy.
Eligibility criteria
Qualifiers
18 years of age or older
Any breast cancer patient initiating doxorubicin/other anthracycline and patients receiving trastuzumab without doxorubicin/anthracycline in the neoadjuvant/adjuvant setting
An understanding of the protocol and its requirements, risks, and discomforts
The ability and willingness to sign an informed consent
Disqualifiers
Inability on the part of the patient to understand the informed consent or be compliant with the protocol
Anemia with hemoglobin less than 8
Patients not willing to undergo a blood draw
Patients with stage IV or distant metastatic breast cancer
Trial design
Treatments tested in this trial
- Biospecimen Collection
- Electronic Medical Record
Treatment groups
200 Participants
are divided into 1 treatment groupLocations
2University of Florida32610, GainesvilleFlorida, United States
Mayo Clinic in Florida32224-9980, JacksonvilleFlorida, United States
Sponsors and collaborators
Mayo Clinic
Lead sponsor
Source ClinicalTrials.gov