Health Trials

About this trial

In recent year, non-intubated anesthesia had emerged as an available and promising alternative for thoracic procedure. However, its safety and feasibility in video-assisted thoracoscopic surgery (VATS) for mediastinal neoplasm remain controversial. This randomized controlled trial is designed to evaluate the impact of the non-intubated approach on surgical and perioperative outcomes in patients undergoing mediastinal neoplasm resection.

Eligibility criteria

Qualifiers

Mediastinal neoplasm was diagnosed by chest enhanced CT

The patients with age ≥ 18 and ≤ 80 years old

The patients whose tumor diameter was <6 cm

ASA grade: I-III

Disqualifiers

Imaging examinations revealed that the tumor had invaded adjacent organs, with evidence of pleural or pericardial dissemination, as well as lymphatic and/or hematogenous metastases

Patients with a confirmed history of congestive heart failure, poorly controlled angina despite medical therapy, electrocardiogram-confirmed myocardial infarction with transmural involvement, uncontrolled hypertension, clinically significant valvular heart disease, or high-risk arrhythmias not adequately managed

Patients with concurrent active malignancies

Trial design

Treatments tested in this trial

  • Non-intubated VATS for mediastinal neoplasm
  • Intubated VATS for mediastinal neoplasm

Treatment groups

132 Participants
are divided into 2 treatment groups

Locations

1
the First Affiliated Hospital of Guangzhou Medical University510120, GuangzhouGuangdong, China

Sponsors and collaborators

Shuben Li

Lead sponsor

The First Affiliated Hospital of Guangzhou Medical University

Sponsor institution

The First Affiliated Hospital of Guangzhou Medical University

Collaborator

Source ClinicalTrials.gov