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Ultrasound Guided Placental Growth Factor Vs Platelet Rich Plasma Injection in Peripheral Nerve Injury: an Interventional Study

ConditionPeripheral Nerve Injury Upper Limb
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age16+
SponsorAssiut University

About this trial

The goal of this clinical trial is to learn if placental growth factor injection and platelet rich plasma injection works to treat peripheral nerve injury in adults. and the role of nerve conduction study and neuromuscular ultrasound

The main questions it aims to answer are:

Does placental growth factor improve outcome after peripheral nerve injury? Does platelet rich plasma improve outcome after peripheral nerve injury? Researchers will compare drug both drugs to each other and will follow up the results via NCS and NMUS

Participants will be classified into 3 random groups:

one group will receive perineural injection of placental growth factor, the other group will receive peri neural PRP injection, third group will only be followed up without intervention Follow up of each patients will be done at 3 and 6 months

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Adult patients older than 16 yrs old.

Patients with traumatic median or ulnar nerve injury who are complaining of symptoms or functional disability.

Patients with these injuries for more than 3 months

Disqualifiers

1- Presence of other causes of nerve affection (entrapment, Diabetes, etc).

Trial design

Design model

Parallel

Treatments tested in this trial

  • perineural injection

    Drug

    perineural intervention of placental growth factor in one group and PRP in other group

Treatment groups

75 Participants
are divided into 3 treatment groups
Group A: group will receive placental growth factor injectionExperimental treatment 1 intervention
Group B: group will receive platelet rich plasma injectionExperimental treatment 1 intervention
Group C: group with only follow upNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

efficacy of placental growth factor injection guided by ultrasound and nerve conduction

pre and post injection follow up will be done my measuring the nerve conduction velocity and amplitude , and by determining the cross sectional area of the nerve by ultrasound

Time frame
one year
2

efficacy of platelet rich plasma injection guided by ultrasound and nerve conduction

pre and post injection parameters of nerve conduction as velocity and amplitude will be measured as will as parameters of ultrasound such as cross sectional area

Time frame
one year

Secondary outcomes

1

diagnosis and follow up of patients by nerve conduction study and neuromuscular US

patients will undergo baseline NCS and NMUS and then follow up the outcome of injection at 3 and 6 months the following parameters will be measured : nerve conduction velocity and amplitude as well as cross sectional area of the nerve

Time frame
one year

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Assiut University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: