[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100589294":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":24,"locations":29,"responsibleParty":54,"collaborators":56,"id":60,"slug":24,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":24,"eligibilityCriteria":65,"healthyVolunteers":66,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":24,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":24,"overallStatus":32,"whyStopped":24,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Study Group","EXPERIMENTAL","Symptomatic patients with claudication, at risk for peripheral arterial disease (PAD)",[13],"Diagnostic Test: Ultrasound Imaging",{"label":15,"type":10,"description":16,"interventionNames":17},"Healthy Volunteers","Healthy volunteers with normal ankle-brachial index (ABI)",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DIAGNOSTIC_TEST","Ultrasound Imaging","Non-invasive ultrasound will be performed using Angio Flow Reactivity Analysis (AFRA)\n\nThe ultrasound probe will be attached to the subject's calf muscle and a pressure cuff will be secured around thigh. Ultrasound data will be collected for 1 minute.\n\nThe cuff will then be induced to a tolerable pressure of no more than 160 mm Hg, and ultrasound data will be collected for 3 minutes while cuff is inflated.\n\nThe cuff pressure will be released, and ultrasound data will be collected for 2 minutes after the release.\n\nSubject will be asked to perform 1 minute plantar flexion exercise, and ultrasound data will be collected for two minutes after the completion of exercise",[15,9],null,[26],{"name":27,"affiliation":5,"role":28},"Azra Alizad","PRINCIPAL_INVESTIGATOR",[30],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Mayo Clinic in Rochester","RECRUITING","Rochester","Minnesota","55905","United States",{"type":38,"coordinates":39},"Point",[40,41],-92.4699,44.02163,{"lat":41,"lon":40},[44,49,53],{"name":45,"role":46,"phone":47,"phoneExt":24,"email":48},"Azra Alizad, MD","CONTACT","507-538-1727","alizad.azra@mayo.edu",{"name":50,"role":46,"phone":51,"phoneExt":24,"email":52},"Fatima Zohra, MS","5075382234","Zohra.Fatima@mayo.edu",{"name":27,"role":28,"phone":24,"phoneExt":24,"email":24},{"type":28,"investigatorFullName":27,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Principal Investigator",[57],{"name":58,"class":59},"National Heart, Lung, and Blood Institute (NHLBI)","NIH","100589294",false,"NCT06952543","Ultrasound Perfusion Estimation for Assessment of Peripheral Arterial Disease","Ultrasound Perfusion Estimation for Assessment of PAD","Inclusion Criteria:\n\nPatient volunteers:\n\n* Male and Female, ages 18 years old and up\n* Symptom of claudication and suspected for PAD\n* Scheduled for vascular testing.\n\nHealthy volunteers:\n\n* Male and female, ages 18-75 years old and up\n* Normal BMI\n* No history of smoking, cardiovascular disease, or diabetes.\n\nExclusion Criteria:\n\nPatient volunteers:\n\n* Patients with gangrene\n* Patients having surgery or stent\n* Patients with ulcer on their leg\n* Any health condition that does not allow proper use of ultrasound scanning\n* People considered in \"vulnerable\" populations.\n\nHealthy volunteers:\n\n* Include volunteers with BMI not more than 30\n* No history of smoking\n* No history of (diabetes, hypertension, cardiovascular diseases)\n* People considered in \"vulnerable\" populations.",true,"ALL","18 Years","75 Years",{"count":71,"type":72},400,"ESTIMATED","INTERVENTIONAL",[75],"NA","The purpose of this study is to develop a new noninvasive tool for early diagnosis of Peripheral Arterial Disease (PAD) and use the proposed method for monitoring the disease progression and the response to interventional treatment in PAD patients.",[78],"Peripheral Arterial Disease","2026-04-29",{"date":81,"type":82},"2026-05-05","ACTUAL",{"date":84,"type":82},"2025-03-14",{"date":86,"type":72},"2029-08-30",{"name":5,"class":6},1]