[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100053897":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":24,"centralContacts":28,"locations":34,"responsibleParty":47,"collaborators":50,"id":54,"slug":10,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":10,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":10,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":10,"overallStatus":36,"whyStopped":10,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"University of Michigan","OTHER",[8,12,15,18,21],{"label":9,"type":10,"description":11,"interventionNames":10},"Normal weight",null,"BMI ≥ 5th percentile \\& \\\u003C 85th percentile",{"label":13,"type":10,"description":14,"interventionNames":10},"Obese weight","BMI ≥ 95th percentile",{"label":16,"type":10,"description":17,"interventionNames":10},"PreDiabetes","HbA1c \\> 5.7%",{"label":19,"type":10,"description":20,"interventionNames":10},"Type 2 Diabetes","Diagnosed with Type 2 Diabetes",{"label":22,"type":10,"description":23,"interventionNames":10},"Overweight","BMI \\> 86th percentile and \\\u003C94th percentile",[25],{"name":26,"affiliation":5,"role":27},"Kanakadurga Singer, MA, MD","PRINCIPAL_INVESTIGATOR",[29],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},"The Singer Lab Team","CONTACT","(734) 615-4938","MiMoStudy@med.umich.edu",[35],{"facility":5,"status":36,"city":37,"state":38,"zip":39,"country":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":10},"RECRUITING","Ann Arbor","Michigan","48109","United States",{"type":42,"coordinates":43},"Point",[44,45],-83.74088,42.27756,{"lat":45,"lon":44},{"type":27,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Kanakadurga Singer","Associate Professor",[51],{"name":52,"class":53},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","NIH","100053897",false,"NCT06007404","Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents","The Role of Circulating Meta-Inflammatory Monocytes in Adolescent Insulin Resistance","Inclusion Criteria:\n\n* Between 14 and 18 years of age\n* Tanner stage 4 or 5 (mature adult stage of puberty)\n* Normal weight (BMI ≥ 5th percentile \\& \\\u003C 85th percentile), overweight (BMI \\> 86th percentile) \\& \\\u003C 94th percentile), obese weight (BMI percentile ≥ 95th percentile), and\u002For pre-diabetes (HbA1c \\> 5.7%)\n* For Type 2 Diabetes cohort, diagnosis of Type 2 Diabetes\n\nExclusion Criteria:\n\n* Currently pregnant\n* Use medications known to affect glucose metabolism (immunosuppressive medications, cancer medications, or high dose steroids), unless prescribed for Type 2 Diabetes management\n* Prior diagnosis of autoimmune disease, cancer, or a cognitive or perceptual disability that would inhibit following directions of study staff\n* Allergies or intolerance to milk, soy, or palm oil",true,"ALL","14 Years","18 Years",{"count":65,"type":66},175,"ESTIMATED","OBSERVATIONAL","This research study collects health-related information and blood samples to better understand how body composition, lifestyle habits, and diet influence meta-inflammatory monocytes (MiMos) in adolescents. The hypothesis of this study is that adolescents at risk for metabolic disease have enhanced MiMo related activities leading to insulin resistance.",[19,70,71,72,16],"Insulin Resistance","Obesity","Metabolic Disease","2026-07-10",{"date":75,"type":76},"2026-07-13","ACTUAL",{"date":78,"type":76},"2023-09-06",{"date":80,"type":66},"2027-09",{"name":5,"class":6},1]