[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100575273":3},{"organization":4,"outcomesModule":7,"designInfo":21,"detailedDescription":16,"studyPopulation":24,"armGroups":25,"interventions":16,"overallOfficials":16,"centralContacts":35,"locations":41,"responsibleParty":54,"collaborators":16,"id":58,"slug":16,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":65,"minAge":66,"maxAge":16,"enrollmentInfo":67,"targetDuration":16,"studyType":70,"phases":16,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":78,"whyStopped":16,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Erasmus Medical Center","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":16},[9],{"measure":10,"description":11,"timeFrame":12},"Differences in bloodmicrobiome between recurrence & non recurrence patients.","To test retrospectively, if we can detect any difference in microbial DNA from the blood of ICR patients that do and do not show recurrence, defined as a Rutgeerts score ≥ i2b at the time of follow-up endoscopy at 6 months.","From enrollment to the postoperative endoscopy (at 6 months follow-up).",[14,17,19],{"measure":15,"description":16,"timeFrame":12},"o To identify blood biomarkers predicting postoperative recurrence in Crohn's disease.",null,{"measure":18,"description":16,"timeFrame":12},"o To identify histological parameters predicting postoperative recurrence in Crohn's disease.",{"measure":20,"description":16,"timeFrame":12},"o To correlate blood biomarkers with fecal biomarkers predicting postoperative recurrence in Crohn's disease.",{"allocation":16,"interventionModel":16,"interventionModelDescription":16,"primaryPurpose":16,"observationalModel":22,"timePerspective":23,"maskingInfo":16},"COHORT","PROSPECTIVE","Patients will be identified at the outpatient clinic at the dept. of gastroenterology or department of surgery or at a multidisciplinary meeting.",[26,29,32],{"label":27,"type":16,"description":28,"interventionNames":16},"Non-recurrence patients","Patients that do not have postoperative recurrence at colonoscopy 6 months after surgery.",{"label":30,"type":16,"description":31,"interventionNames":16},"Recurrence patients","Patients that do have postoperative recurrence at colonoscopy 6 months after surgery.",{"label":33,"type":16,"description":34,"interventionNames":16},"Healthy controls","Patients without Inflammatory Bowel Disease",[36],{"name":37,"role":38,"phone":39,"phoneExt":16,"email":40},"Merel Verweij, MD","CONTACT","+31650033976","m.verweij@erasmusmc.nl",[42],{"facility":5,"status":16,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":16},"Rotterdam","South Holland","3015 GD","Netherlands","NL",{"type":49,"coordinates":50},"Point",[51,52],4.47917,51.9225,{"lat":52,"lon":51},{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":16,"oldOrganization":16},"PRINCIPAL_INVESTIGATOR","Merel Verweij","MD","100575273",false,"NCT06770140","Unraveling the Blood Microbiome in Postoperative Recurrence of Crohn's Disease","IBDbloom","Inclusion Criteria:\n\n* Diagnosis of Crohn's Disease\n* Adult ≥ 16 years\n* Undergoing an ileocolonic resection or reresection\n* Written informed consent\n\nExclusion Criteria:\n\n* Use of antibiotics in the past 8 weeks at the timepoints when blood is withdrawn and feces is collected.\n* Use of probiotics in the past 8 weeks at the timepoints when blood is withdrawn and feces is collected.\n* Not willing to collect extra biosamples",true,"ALL","16 Years",{"count":68,"type":69},70,"ESTIMATED","OBSERVATIONAL","Crohn's disease, a chronic inflammation of the gastro-intestinal tract, is a disease with a complex pathogenetic background. Hereditary factors, environmental factors and the gut flora play a varying role in its onset, however, this role remains unclear to date. We hypothesize to detect tiny fragments of microbial DNA from the gut in the bloodstream, due to disruption in the natural defences of the gut lining. If this is true, it may hold the key to understanding why Crohn's disease recurs after surgery.\n\nOur objective in this study is to test retrospectively, if we can detect any difference in microbial DNA from the blood of ileocolonic resection (ICR) patients that do and do not show recurrence at the time of follow-up endoscopy at 6 months.",[73],"Crohn's Disease (CD)",[75,76,77],"Ileocolonic resection","Blood microbiome","Postoperative recurrence","NOT_YET_RECRUITING","2025-01-07",{"date":81,"type":82},"2025-01-13","ACTUAL",{"date":84,"type":69},"2025-02",{"date":86,"type":69},"2027-02",{"name":5,"class":6},1]