[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100552307":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":24,"locations":30,"responsibleParty":47,"collaborators":10,"id":51,"slug":10,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":52,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":10,"studyType":64,"phases":10,"briefSummary":65,"conditions":66,"keywords":73,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"University of Cyprus","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Abstainers",null,"Participants who achieve biochemically-verified smoking abstinence for at least 6 months following a cessation attempt aided by a computerized intervention program.",[13],"Behavioral: Flexiquit Smoking Cessation Intervention",{"label":15,"type":10,"description":16,"interventionNames":17},"Relapsers","Participants who do not achieve abstinence and relapse to smoking following the cessation attempt.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"BEHAVIORAL","Flexiquit Smoking Cessation Intervention","Participants will enter a 6-week (once weekly) self-delivered computerized intervention program called Flexiquit. Developed and validated by Clinical Psychologists of the Department of Psychology at the University of Cyprus, Flexiquit is an avatar-led app designed to support smoking cessation. It aims to assist with abstinence and monitor participants' progress through personalized modules and assessments.",[9,15],[25],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Andrea N Georgiou, Ph.D.","CONTACT","(+357)-22893372","georgiou.andrea@ucy.a.cy",[31],{"facility":32,"status":33,"city":34,"state":10,"zip":35,"country":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Center for Applied Neuroscience (CAN)","RECRUITING","Nicosia","2100","Cyprus",{"type":38,"coordinates":39},"Point",[40,41],33.35397,35.17284,{"lat":41,"lon":40},[44],{"name":45,"role":27,"phone":10,"phoneExt":10,"email":46},"Andrea Georgiou, Ph.D.","georgiou.andrea@ucy.ac.cy",{"type":48,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Panos Zanos","Assistant Professor","100552307",false,"NCT06471387","Unraveling the Genetic Basis of Nicotine Addiction for Novel Therapeutic Strategies","Exploring the Genetic and Molecular Underpinning of Nicotine Addiction for the Development of New Therapeutic Strategies","NicoGen","Inclusion Criteria:\n\n* Adults aged 18-60 years old\n* Current daily cigarette smoker\n* Able to understand study procedures and provide informed consent\n* For females, non-pregnant and non-lactating\n\nExclusion Criteria:\n\n* Presence of significant uncontrolled medical conditions (e.g. cardiovascular disease, respiratory disorders, cancer) that could affect smoking behaviors or study participation\n* Presence of major uncontrolled psychiatric disorders (e.g. schizophrenia, bipolar disorder, severe depression)\n* Current substance use disorder (except nicotine dependence)\n* Taking medications that could significantly interfere with study objectives (e.g. medications for smoking cessation)\n* Significant cognitive impairment that precludes ability to complete study procedures","ALL","18 Years","60 Years",{"count":62,"type":63},200,"ESTIMATED","OBSERVATIONAL","This case-control study aims to investigate the genetic and molecular bases of nicotine addiction to identify potential therapeutic targets. The project will involve drug repurposing using Mendelian Randomization, a smoking cessation intervention, and the analysis of methylation status in participants undergoing nicotine withdrawal.",[67,68,69,70,71,72],"Smoking Cessation","Smoking Cessation Intervention","Nicotine Addiction","Epigenetics","Molecular Biology","Genetic Epidemiology",[69,67,74,75,72,76,77],"Mendelian Randomization","Methylation","Drug Repurposing","Epigenetic Biomarkers","2024-06-23",{"date":80,"type":81},"2024-06-25","ACTUAL",{"date":83,"type":81},"2023-11-01",{"date":85,"type":63},"2025-10-31",{"name":5,"class":6},1]