[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100385501":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":30,"locations":40,"responsibleParty":203,"collaborators":206,"id":209,"slug":24,"hasResults":210,"nctId":211,"briefTitle":212,"officialTitle":213,"acronym":214,"eligibilityCriteria":215,"healthyVolunteers":210,"sex":216,"minAge":217,"maxAge":218,"enrollmentInfo":219,"targetDuration":24,"studyType":222,"phases":223,"briefSummary":225,"conditions":226,"keywords":24,"overallStatus":232,"whyStopped":24,"lastUpdateSubmitDate":233,"lastUpdatePostDateStruct":234,"startDateStruct":237,"completionDateStruct":239,"leadSponsor":241,"locationsCount":242},{"fullName":5,"class":6},"KU Leuven","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"HTM plus UPP","EXPERIMENTAL","Urinary proteomic profiling administered on top of home blood pressure telemonitoring and guideline-endorsed non-pharmacological and pharmacological management of risk factors",[13],"Diagnostic Test: In-vitro urinary diagnostic test",{"label":15,"type":6,"description":16,"interventionNames":17},"HTM alone","Home blood pressure telemonitoring administered on top of non-pharmacological and pharmacological management of risk factors",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DIAGNOSTIC_TEST","In-vitro urinary diagnostic test","Urinary proteomic profiling (UPP) using established multidimensional urinary markers for progression to CKD (CKD273), left ventricular dysfunction (HF1 and HF2) and coronary heart disease (CAD238 and ACSP75) - in-vitro test certified in Germany and by extension in the EU (DE\u002FCA09\u002F0829\u002FIVD\u002F001, DE\u002FCA09\u002F0829\u002FIVD\u002F005).",[15,9],null,[26],{"name":27,"affiliation":28,"role":29},"Lutgarde Thijs, MSc","University of Leuven","PRINCIPAL_INVESTIGATOR",[31,36],{"name":32,"role":33,"phone":34,"phoneExt":24,"email":35},"Jan A Staessen, MD, PhD","CONTACT","+32 47 632 4928","jan.staessen@med.kuleuven.be",{"name":37,"role":33,"phone":38,"phoneExt":24,"email":39},"Zen-Yu Zhang, MD, PhD","+32 16 34 7104","zhenyu.zhang@med.kuleuven.be",[41,52,61,70,85,95,105,120,140,155,169,188],{"facility":42,"status":24,"city":43,"state":24,"zip":44,"country":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":24},"European Kidney Health Aliance","Brussels","1000","Belgium",{"type":47,"coordinates":48},"Point",[49,50],4.34878,50.85045,{"lat":50,"lon":49},{"facility":53,"status":24,"city":54,"state":24,"zip":55,"country":45,"cosmosGeoPoint":56,"geoPoint":60,"contacts":24},"Diabetes Liga","Ghent","9000",{"type":47,"coordinates":57},[58,59],3.71667,51.05,{"lat":59,"lon":58},{"facility":62,"status":24,"city":63,"state":24,"zip":64,"country":45,"cosmosGeoPoint":65,"geoPoint":69,"contacts":24},"Alliance for the Promotion of Preventive Medicine","Mechelen","2800",{"type":47,"coordinates":66},[67,68],4.47762,51.02574,{"lat":68,"lon":67},{"facility":71,"status":24,"city":72,"state":24,"zip":73,"country":74,"cosmosGeoPoint":75,"geoPoint":79,"contacts":80},"Steno Diabetes Center Copenhagen","Gentofte Municipality","2820","Denmark",{"type":47,"coordinates":76},[77,78],12.54601,55.74903,{"lat":78,"lon":77},[81],{"name":82,"role":33,"phone":83,"phoneExt":24,"email":84},"Tine W Hansen, MD, PhD","+45 39 68 08 00","tine.willum.hansen@regionh.dk",{"facility":86,"status":24,"city":87,"state":24,"zip":88,"country":89,"cosmosGeoPoint":90,"geoPoint":94,"contacts":24},"Mosaiques-Diagnoostics and Therapeutics AG","Hanover","D-30659","Germany",{"type":47,"coordinates":91},[92,93],9.73322,52.37052,{"lat":93,"lon":92},{"facility":96,"status":24,"city":97,"state":24,"zip":98,"country":99,"cosmosGeoPoint":100,"geoPoint":104,"contacts":24},"Biomedical Research Foundation of the Academy of Athens","Athens","115 27","Greece",{"type":47,"coordinates":101},[102,103],23.72784,37.98376,{"lat":103,"lon":102},{"facility":106,"status":24,"city":107,"state":24,"zip":108,"country":109,"cosmosGeoPoint":110,"geoPoint":114,"contacts":115},"Department of Internal Medicine, Faculty of Clinical Sciences, College of Health Sciences, University of Abuja","Abuja","NCT Airport Road","Nigeria",{"type":47,"coordinates":111},[112,113],7.49508,9.05785,{"lat":113,"lon":112},[116],{"name":117,"role":33,"phone":118,"phoneExt":24,"email":119},"Augustine N Odili, MD, PhD","+234 803 395 4983","odilimercy@yahoo.com",{"facility":121,"status":24,"city":122,"state":24,"zip":123,"country":124,"cosmosGeoPoint":125,"geoPoint":129,"contacts":130},"Department of Hypertension, Medical University of Gdańsk","Gdansk","80-214","Poland",{"type":47,"coordinates":126},[127,128],18.64912,54.35227,{"lat":128,"lon":127},[131,134,137],{"name":132,"role":33,"phone":24,"phoneExt":24,"email":133},"Krzysztof Narkiewicz, MD, PhD","krzysztof.narkiewicz@gumed.edu.pl",{"name":135,"role":33,"phone":136,"phoneExt":24,"email":24},"Mariana Smoluchowskiego","+58 584 44 40",{"name":138,"role":139,"phone":24,"phoneExt":24,"email":24},"Natasza Gilis-Malinowska","SUB_INVESTIGATOR",{"facility":141,"status":24,"city":142,"state":24,"zip":24,"country":124,"cosmosGeoPoint":143,"geoPoint":147,"contacts":148},"First Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University Medical College","Krakow",{"type":47,"coordinates":144},[145,146],19.93658,50.06143,{"lat":146,"lon":145},[149,153],{"name":150,"role":33,"phone":151,"phoneExt":24,"email":152},"Marek Raizer, MD, PhD","+4812 4002150","marek.raizer@uj.edu.pl",{"name":154,"role":139,"phone":24,"phoneExt":24,"email":24},"Katarzyna Stolarz-Skrzypek, MD, PhD",{"facility":156,"status":24,"city":157,"state":24,"zip":44,"country":158,"cosmosGeoPoint":159,"geoPoint":163,"contacts":164},"Department of Internal Medicine, Division of Hypertension, University Medical Centre Ljubljana","Ljubljana","Slovenia",{"type":47,"coordinates":160},[161,162],14.50513,46.05108,{"lat":162,"lon":161},[165],{"name":166,"role":33,"phone":167,"phoneExt":24,"email":168},"Jana Brguljan Hitij, MD, PhD","+386 1 522 50 50","jana.brguljan-hitij@guest.arnes.si",{"facility":170,"status":24,"city":171,"state":24,"zip":172,"country":173,"cosmosGeoPoint":174,"geoPoint":178,"contacts":179},"Hypertension in Africa Research Team, Medical Research Council Unit for Hypertension and Cardiovascular Disease, North-West University","Potchefstroom","2520","South Africa",{"type":47,"coordinates":175},[176,177],27.1,-26.71667,{"lat":177,"lon":176},[180,184,186],{"name":181,"role":33,"phone":182,"phoneExt":24,"email":183},"Alta Schutte, MD, PhD","+27 18 299 1111","alta.schutte@nwu.ac.za",{"name":185,"role":139,"phone":24,"phoneExt":24,"email":24},"Carina Mels, MD, PhD",{"name":187,"role":139,"phone":24,"phoneExt":24,"email":24},"Gontse Mokwatsi, MD, PhD",{"facility":189,"status":24,"city":190,"state":24,"zip":191,"country":192,"cosmosGeoPoint":193,"geoPoint":197,"contacts":198},"Centro de Nefrología and Departamento de Fisiopatología, Hospital de Clínicas, Universidad de la República","Montevideo","11600","Uruguay",{"type":47,"coordinates":194},[195,196],-56.18816,-34.90328,{"lat":196,"lon":195},[199],{"name":200,"role":33,"phone":201,"phoneExt":24,"email":202},"José Boggia, MD, PhD","+598 2480 98 50","ppboggia@gmail.com",{"type":29,"investigatorFullName":204,"investigatorTitle":205,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Jan A. Staessen","Professor of Medicine",[207],{"name":62,"class":208},"UNKNOWN","100385501",false,"NCT04299529","Urinary Proteomics Combined With Home Blood Pressure Telemonitoring for Health Care Reform","Urinary Proteomics Combined With Home Blood Pressure Telemonitoring for Health Care Reform: a Randomised Controlled Trial","UPRIGHT-HTM","Inclusion Criteria:\n\n* Patients must have at least three additional guideline-defined risk factors, preferably including hypertension, type 2 diabetes mellitus (T2DM), or both;\n* Patients should be willing patients to engage for the duration of the study in home blood pressure telemonitoring (1 reading per day);\n* Patients must have an email address and internet access via smartphone, tablet, or laptop or desktop computer;\n* Patients should comply with the study protocol during the run-in phase.\n\nExclusion Criteria:\n\n* Type 1 diabetes mellitus;\n* Absence of a practicable echocardiographic window;\n* Previous or concurrent severe cardiovascular or non-cardiovascular disease;\n* Cancer within 5 years of enrolment;\n* Suspected substance abuse;\n* Psychiatric illness;\n* Use of nephrotoxic drugs;\n* Particpation in another clinical study.","ALL","55 Years","75 Years",{"count":220,"type":221},1000,"ESTIMATED","INTERVENTIONAL",[224],"NA","UPRIGHT-HTM will compare risk stratification, treatment efficiency and health economic outcomes of a diagnostic approach based on home blood pressure telemonitoring combined with urinary proteomic profiling with home blood pressure telemonitoring alone",[227,228,229,230,231],"Protein Deregulation","Blood Pressure","Health Care Utilization","Cost Effectiveness","Patient Empowerment","NOT_YET_RECRUITING","2020-03-05",{"date":235,"type":236},"2020-03-06","ACTUAL",{"date":238,"type":221},"2020-04-01",{"date":240,"type":221},"2026-07-31",{"name":5,"class":6},12]