[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100063220":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":17,"centralContacts":22,"locations":31,"responsibleParty":45,"collaborators":10,"id":47,"slug":10,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":10,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":10,"studyType":60,"phases":10,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":34,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":10,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"National Institutes of Health Clinical Center (CC)","NIH",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Diabetes Type I",null,"Subjects with Type I diabetes mellitus",{"label":13,"type":10,"description":14,"interventionNames":10},"Diabetes Type II","Subjects with Type II diabetes mellitus",{"label":16,"type":10,"description":16,"interventionNames":10},"Healthy Volunteers",[18],{"name":19,"affiliation":20,"role":21},"Ifechukwude C Ebenuwa, M.D.","National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","PRINCIPAL_INVESTIGATOR",[23,28],{"name":24,"role":25,"phone":26,"phoneExt":10,"email":27},"Razi S Berman, C.R.N.P.","CONTACT","(301) 827-5757","razi.berman@nih.gov",{"name":19,"role":25,"phone":29,"phoneExt":10,"email":30},"(301) 435-6582","ifechukwude.ebenuwa@nih.gov",[32],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":10},"National Institutes of Health Clinical Center","RECRUITING","Bethesda","Maryland","20892","United States",{"type":40,"coordinates":41},"Point",[42,43],-77.10026,38.98067,{"lat":43,"lon":42},{"type":46,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100063220",false,"NCT00071526","Urinary Vitamin C Loss in Diabetic Subjects","Urinary Vitamin C Loss in Subjects With and Without Diabetes","* INCLUSION CRITERIA:\n\nTo be included in the study, study subjects should be:\n\n* Aged 18-65 years.\n* Either:\n\n  * Have no diagnosis of diabetes: \"nondiabetic controls\", or\n  * Have a diagnosis in their medical history of either Type 1 or Type 2 diabetes\n\nEXCLUSION CRITERIA (for outpatient study, arm 1)\n\nExclusion criteria will include the following:\n\n* Unable or unwilling to provide a signed and dated informed consent form\n* Unable or unwilling to comply with study procedures and lifestyle considerations\n\nEXCLUSION CRITERIA (for inpatient studies, arms 2 and 3)\n\nStudy participants interested in participating in Arms 2 and\u002For 3 will be excluded from this further participation if they meet any of the following:\n\n* significant organ malfunction leading to clinical instability including liver disease, pulmonary disease, ischemic heart disease, heart failure, stroke, peripheral vascular disease, and anemia at investigator discretion\n* other serious or chronic illness; history of serious or chronic illness; coronary artery disease, or peripheral vascular disease resulting in clinical instability\n* pregnancy or lactation\n* presence of other conditions which, in the judgment of the investigators, can influence vitamin C metabolism or vitamin C renal handling",true,"ALL","18 Years","65 Years",{"count":58,"type":59},5000,"ESTIMATED","OBSERVATIONAL","Several studies have reported that diabetic subjects have lower plasma vitamin C concentrations than non-diabetic subjects. Although urinary vitamin C loss in diabetic subjects was reported to be increased in two studies, these are difficult to interpret due to lack of controlled vitamin C intake, inadequate sampling, lack of control subjects, or methodology uncertainties in vitamin C assay and sample processing. Consequently, it is unclear whether diabetic subjects truly have both low plasma and high urine vitamin C concentrations. We propose that low plasma vitamin C concentrations in diabetic subjects are due in part to inappropriate renal loss of vitamin C in these subjects but not in healthy controls. We will study nondiabetic controls and cohorts with diabetes. Vitamin C concentrations in plasma, RBCs, and urine will be measured in outpatients. In those willing to be admitted to the Clinical Center, we will measure vitamin C pharmacokinetics to determine the relative bioavailability for vitamin C in individuals with and without abnormal urinary loss of vitamin C (or renal leak). Single nucleotide polymorphisms (SNPs) will be determined in genomic DNA responsible for the two proteins mediating sodium dependent vitamin C transport, SVCT1 and SVCT2. We will also explore mechanisms underlying abnormal urinary vitamin C loss....",[63],"Diabetes",[65,66,67,68,69],"Renal Threshold","Diabetes Mellitus","Proteinuria","Plasma Concentrations","Healthy Volunteer","2026-06-17",{"date":72,"type":73},"2026-06-18","ACTUAL",{"date":75,"type":73},"2006-04-11",{"name":20,"class":6},1]