About this trial

The use of extracorporeal blood purification therapies (EBPT) is becoming increasingly widespread worldwide in everyday clinical practice, particularly in the critical care setting. Nonetheless, most of the clinical trials aimed at exploring the effect of EBPT on patients' long-term outcomes have failed to demonstrate consistent results regarding 28 day- or hospital- mortality rates. The aim of this observational prospective registry is to evaluate if there is a cluster of critically ill patients that mostly benefits from extracorporeal blood purification therapies with different EBPTs.

Eligibility criteria

Qualifiers

critically ill patients in the ICU

CRRT/IHD/Hybrid therapies for support//replacement renal function

immunomodulation achieved by "high cut-off membranes", "endotoxins and/or cytokines adsorbent membranes" or by high-volume hemofiltration

Disqualifiers

patients treated only by Cytosorb® and/or Toraymyxin® therapies

Trial design

Treatments tested in this trial

  • Commercial membrane for Extracorporeal Blood Purification Therapy (EBPT)

Treatment groups

1,000 Participants
are divided into 1 treatment group

Locations

15
Ospedale S. Giuseppe50053, EmpoliFirenze, Italy
Ospedale Versilia55049, Lido di CamaioreLucca, Italy
Humanitas Research Hospital20089, RozzanoMilano, Italy
IRCCS Policlinico S. Donato20097, San Donato MilaneseMilano, Italy

Sponsors and collaborators

Careggi Hospital

Lead sponsor

University of Florence

Collaborator