Usefulness of PET-CT for Invasive Fungal Infection

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorPuerta de Hierro University Hospital

About this trial

The goal of this national multicenter prospective cohort study is to learn about the added value of 18F-FDG (18F-2-fluoro-2-deoxy-D-glucose) PET-CT in invasive fungal disease management. The main questions it aims to answer are:

1. Does the use of 18F-FDG PET-CT allow a better characterization of invasive fungal infection (IFI) (performance) compared to the exclusive use of conventional radiological studies in terms of extension/staging and monitoring of response/follow-up ? 2. Does the systematic and protocolized use of 18F-FDG PET-CT in IFI allow a better management of patients with IFI and increase the prognostic value of the initial evaluation? Participants will undergo systematically a 18F-FDG PET-CT as part of the work-up of their invasive fungal disease. Researchers will compare the performance of 18F-FDG PET-CT with standard management without 18F-FDG PET-CT to see if adds value (diagnostic, prognostic, and changes in management).

Eligibility criteria

Qualifiers

18-year-old adult patients

who are admitted with a diagnosis of invasive fungal infection

who able to undergo a one 18F-FDG PET-CT

who give their informed consent.

Disqualifiers

concomitant active bacterial infection likely to produce uptake in organs and tissues

recent surgery in the area of the IFI (in the previous 3 months)

other medical conditions that interfere with the development of the study ( e.g., inability to tolerate the performance of the test during the required time, pregnancy)

terminal situation.

Trial design

Treatments tested in this trial

  • PET-CT

Treatment groups

No treatment groups listed

Locations

14
Hospital Universitario Puerta de Hierro28222, MajadahondaMadriid, Spain
Hospital de Bellvitge Barcelona Spain
Hospital Universitario Clinic Barcelona Spain
Hospital Universitario Virgen de las Nieves Granada Spain

Sponsors and collaborators

Puerta de Hierro University Hospital

Lead sponsor

Gilead Sciences

Collaborator