The goal of this clinical trial is to learn if using artificial intelligence to guide intravenous fluid therapy during major cancer surgery can help keep blood pressure more stable compared with usual care in adult patients undergoing major cancer surgery. The main questions it aims to answer are:
* Does artificial intelligence-guided fluid therapy reduce hypotensive events during surgery? * Does this approach improve recovery and reduce complications after major cancer surgery?
Researchers will compare artificial intelligence-guided fluid therapy with standard fluid management to see if the artificial intelligence-guided approach provides better support during surgery.
Participants will:
* Undergo major cancer surgery under general anesthesia * Receive either artificial intelligence-guided fluid management or standard fluid management during surgery * Be monitored during and after surgery as part of routine clinical care * Be followed after surgery to assess recovery and possible complications
Age ≥ 18 years
American Society of Anesthesiologists (ASA) Physical Status II-IV
Undergoing major abdominal oncologic surgery (open or laparoscopic) with an expected duration >2 hours
Planned invasive arterial pressure monitoring
Significant arrhythmias (e.g., persistent atrial fibrillation)
Severe aortic stenosis
Emergency surgery
Sepsis
National Cancer Institute, Naples
Lead sponsor