[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100519007":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":26,"centralContacts":30,"locations":38,"responsibleParty":120,"collaborators":122,"id":126,"slug":21,"hasResults":127,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":21,"eligibilityCriteria":131,"healthyVolunteers":127,"sex":132,"minAge":133,"maxAge":134,"enrollmentInfo":135,"targetDuration":21,"studyType":138,"phases":139,"briefSummary":141,"conditions":142,"keywords":144,"overallStatus":41,"whyStopped":21,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":157},{"fullName":5,"class":6},"Memorial Sloan Kettering Cancer Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"E-Nose Technology","EXPERIMENTAL","Patients undergo a breathprinting test (E-Nose) at baseline and at the first three standard of care follow-ups, as scheduled by their treating physician, that involve a CT of the Chest and\u002For PET\u002FCT. The E-Nose testing will be administered by trained staff. Staff will use proper personal protective equipment during collections. Subjects will undergo E-Nose testing in a presurgical or interventional radiology suite. Subjects must consent to no smoking, no tooth brushing, and no food or drinks starting on midnight of the day of the E-Nose test. If fasting from midnight until the E-Nose test is not feasible, subjects may consent to fasting for 2 hours prior to each E-Nose test. Subjects opting to fast for 2 hours before each E-Nose test can only have still, non-carbonated water and non-aromatic foods or foods that do not develop aromatic compounds, such as low salt simple crackers, starting at midnight on the day of the E-Nose test until 2 hours before the collection.",[13,14],"Diagnostic Test: E-Nose testing","Diagnostic Test: Research blood",[16,22],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"DIAGNOSTIC_TEST","E-Nose testing","At baseline (before any treatment is administered) approximately when the patient is scheduled for a CT of the Chest and\u002For PET\u002FCT after initiation of any treatment, as medically permissible and at the PI's discretion. A breath sample from each patient will be captured in a cartridge, which will form the basis for the E-Nose analysis, to be performed by study investigators at UCB.",[9],null,{"type":17,"name":23,"description":24,"armGroupLabels":25,"otherNames":21},"Research blood","Research blood tests will be obtained at baseline and the first three standard of care follow up visits, scheduled by their treating physician along with a CT of the Chest and\u002For PET\u002FCT1 to determine whether serum biomarkers of MPM.",[9],[27],{"name":28,"affiliation":5,"role":29},"Gaetano Rocco, MD","PRINCIPAL_INVESTIGATOR",[31,35],{"name":28,"role":32,"phone":33,"phoneExt":21,"email":34},"CONTACT","212-639-3478","roccog@mskcc.org",{"name":36,"role":32,"phone":37,"phoneExt":21,"email":21},"David Jones, MD","212-639-6428",[39,54,65,76,88,99,109],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Memorial Sloan Kettering Basking Ridge (Consent Only)","RECRUITING","Basking Ridge","New Jersey","07920","United States",{"type":47,"coordinates":48},"Point",[49,50],-74.54932,40.70621,{"lat":50,"lon":49},[53],{"name":28,"role":32,"phone":33,"phoneExt":21,"email":21},{"facility":55,"status":41,"city":56,"state":43,"zip":57,"country":45,"cosmosGeoPoint":58,"geoPoint":62,"contacts":63},"Memorial Sloan Kettering Monmouth (Consent Only)","Middletown","07748",{"type":47,"coordinates":59},[60,61],-74.11709,40.39428,{"lat":61,"lon":60},[64],{"name":28,"role":32,"phone":33,"phoneExt":21,"email":21},{"facility":66,"status":41,"city":67,"state":43,"zip":68,"country":45,"cosmosGeoPoint":69,"geoPoint":73,"contacts":74},"Memorial Sloan Kettering Bergen (Consent Only )","Montvale","07645",{"type":47,"coordinates":70},[71,72],-74.02292,41.04676,{"lat":72,"lon":71},[75],{"name":28,"role":32,"phone":33,"phoneExt":21,"email":21},{"facility":77,"status":41,"city":78,"state":79,"zip":80,"country":45,"cosmosGeoPoint":81,"geoPoint":85,"contacts":86},"Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (Consent Only)","Commack","New York","11725",{"type":47,"coordinates":82},[83,84],-73.29289,40.84288,{"lat":84,"lon":83},[87],{"name":28,"role":32,"phone":33,"phoneExt":21,"email":21},{"facility":89,"status":41,"city":90,"state":79,"zip":91,"country":45,"cosmosGeoPoint":92,"geoPoint":96,"contacts":97},"Memorial Sloan Kettering Westchester (Consent Only)","Harrison","10604",{"type":47,"coordinates":93},[94,95],-73.71263,40.96899,{"lat":95,"lon":94},[98],{"name":28,"role":32,"phone":33,"phoneExt":21,"email":21},{"facility":100,"status":41,"city":79,"state":79,"zip":101,"country":45,"cosmosGeoPoint":102,"geoPoint":106,"contacts":107},"Memorial Sloan Kettering Cancer Center (All Protocol Activities)","10065",{"type":47,"coordinates":103},[104,105],-74.00597,40.71427,{"lat":105,"lon":104},[108],{"name":28,"role":32,"phone":33,"phoneExt":21,"email":21},{"facility":110,"status":41,"city":111,"state":79,"zip":112,"country":45,"cosmosGeoPoint":113,"geoPoint":117,"contacts":118},"Memorial Sloan Kettering Nassau (Consent Only)","Uniondale","11553",{"type":47,"coordinates":114},[115,116],-73.59291,40.70038,{"lat":116,"lon":115},[119],{"name":28,"role":32,"phone":33,"phoneExt":21,"email":21},{"type":121,"investigatorFullName":21,"investigatorTitle":21,"investigatorAffiliation":21,"oldNameTitle":21,"oldOrganization":21},"SPONSOR",[123],{"name":124,"class":125},"UNIVERSITY CAMPUS BIO-MEDICO, ITALY","UNKNOWN","100519007",false,"NCT06037941","Using E-Nose Technology to Measure Response to Treatment in People With Malignant Pleural Mesothelioma","Breathprinting (E-Nose) Technology to Measure Response to Treatment of Malignant Pleural Mesothelioma (MPM) Through MPM-Specific Volatile Organic Compounds Detected in Exhalates","Inclusion Criteria:\n\n* Aged 30-85 years\n* No history of thoracic cancer or extrathoracic cancer potentially involving pleural metastases (i.e., breast, gastric, colon, or pancreas cancer)\n* Recent diagnosis of MPM\n* Documented, signed, and dated informed consent, obtained before any procedures, for the proposed research study, and signed standard surgical consent for surgical resection\n\nExclusion Criteria:\n\n* Aged \\\u003C30 or \\>85 years at the first outpatient visit\n* History of thoracic or extrathoracic cancer that puts the subject at risk for pleural or pulmonary metastases","ALL","30 Years","85 Years",{"count":136,"type":137},20,"ESTIMATED","INTERVENTIONAL",[140],"NA","The researchers are doing this study to test the ability of a new technology called breathprinting, or electronic nose (E-Nose), to measure how people respond to standard treatment for malignant pleural mesothelioma (MPM). The researchers will study how E-Nose breathprints change over time as people receive standard treatment for MPM. They will also look at how changes in people's E-Nose breathprints compare to changes in their standard imaging scans and in biomarkers of MPM in their blood.",[143],"Malignant Pleural Mesothelioma",[145,146,147],"Breathprinting (E-Nose) Technology","MPM-Specific Volatile Organic Compounds","23-100","2025-09-18",{"date":150,"type":151},"2025-09-22","ACTUAL",{"date":153,"type":151},"2023-09-08",{"date":155,"type":137},"2026-09",{"name":5,"class":6},7]