[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100505899":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":37,"locations":45,"responsibleParty":61,"collaborators":64,"id":69,"slug":25,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":70,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":25,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":48,"whyStopped":25,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"University of Southern California","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"HEPA first and sham","EXPERIMENTAL","This group of participants will be assigned to the intervention of HEPA filtration with the capacity to reduce indoor PM2.5 levels at their residence for 9 months first. After 3-month wash-out period, participants will be assigned to sham filters (air purifier has the same appearance but HEPA filter is removed) for 9 months.",[13,14],"Device: HEPA filtration","Device: Sham filtration",{"label":16,"type":10,"description":17,"interventionNames":18},"Sham first and HEPA","This group of participants will be assigned to the intervention of sham filtration with HEPA filter removed at their residence for 9 months first. After 3-month wash-out period, participants will be assigned to the HEPA filtration for 9 months.",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","HEPA filtration","HEPA filters with the capacity to reduce PM2.5 levels",[9,16],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Sham filtration","Sham filtration use the same appearance of air purifier but with HEPA filter removed.",[9,16],[31,34],{"name":32,"affiliation":5,"role":33},"Zhanghua Chen, PhD","PRINCIPAL_INVESTIGATOR",{"name":35,"affiliation":36,"role":33},"Junfeng Zhang, PhD","Duke University",[38,42],{"name":32,"role":39,"phone":40,"phoneExt":25,"email":41},"CONTACT","323-442-2109","zhanghuc@usc.edu",{"name":35,"role":39,"phone":43,"phoneExt":25,"email":44},"919-681-7782","junfeng.zhang@duke.edu",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Keck School of Medicine, University of Southern California","RECRUITING","Los Angeles","California","90033","United States",{"type":54,"coordinates":55},"Point",[56,57],-118.24368,34.05223,{"lat":57,"lon":56},[60],{"name":32,"role":39,"phone":40,"phoneExt":25,"email":41},{"type":33,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Zhanghua Chen","Assistant Professor",[65,66],{"name":36,"class":6},{"name":67,"class":68},"National Institute of Environmental Health Sciences (NIEHS)","NIH","100505899",false,"NCT05867381","Using Indoor Air Filtration to Slow Atherothrombosis Progression in Adults With Ischemic Heart Disease History","Slowing Atherothrombosis Progression Through Indoor Air Filtration: A Crossover Trial in Hispanic and Non-Hispanic Adults With Ischemic Heart Disease History","SAPIA","Inclusion Criteria:\n\n* Age between 65 and 84 years old;\n* Weight ≥ 110 pounds;\n* Nonsmokers for at least 1 year;\n* Have ischemic heart disease history, clinically stable for 6 months, without any deterioration in symptoms or episodes of angina based on past electronic medical records;\n* Both English and Spanish speaking participants will be included in the recruitment;\n* Live in the Los Angeles County.\n\nExclusion Criteria:\n\n* Have history of degenerative disease of the nervous system such as dementia and Alzheimer's;\n* Currently have active cancer treatments;\n* The residential house has already had HEPA filters;\n* Participants will move out from the current residential address in the next 2 years;\n* Participants will spend more than 1 month living outside the primary home;\n* Have any health conditions that prohibit collecting health and covariate data and biospecimens;\n* Participants' residential houses are not feasible for setting up air purifiers and air pollutants monitors.","ALL","65 Years","84 Years",{"count":80,"type":81},112,"ESTIMATED","INTERVENTIONAL",[84],"NA","This double-blind, randomized, crossover trial aims to test the hypothesis that longer-term indoor air filtration intervention can slow atherothrombosis progression by reducing indoor fine particulate matter (PM2.5) exposure in adults with ischemic heart disease history.",[87,88],"Air Pollution","Atherosclerosis",[90,91,92,93,88,94,95,96],"Air pollution","Particulate matter","Air purifier","HEPA filter","Ischemic Heart Disease","Thrombosis","Cardiovascular Disease","2026-06-04",{"date":99,"type":100},"2026-06-08","ACTUAL",{"date":102,"type":100},"2023-07-11",{"date":104,"type":81},"2028-06-30",{"name":5,"class":6},1]