[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100538596":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":10,"centralContacts":19,"locations":25,"responsibleParty":40,"collaborators":44,"id":48,"slug":10,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":49,"sex":55,"minAge":56,"maxAge":10,"enrollmentInfo":57,"targetDuration":10,"studyType":60,"phases":10,"briefSummary":61,"conditions":62,"keywords":10,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico","OTHER",[8,13],{"label":9,"type":10,"description":10,"interventionNames":11},"obese individuals [Body Mass Index (BMI) > 30 affected by prostate cancer",null,[12],"Other: observational study",{"label":14,"type":10,"description":10,"interventionNames":10},"normal-weight individuals [18 \u003C BMI \u003C 25] affected by prostate cancer",[16],{"type":6,"name":17,"description":17,"armGroupLabels":18,"otherNames":10},"observational study",[9],[20],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Giancarlo Albo, MD,","CONTACT","00390255034501","giancarlo.albo@policlinico.mi.it",[26],{"facility":27,"status":28,"city":29,"state":10,"zip":10,"country":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"IRCCS Cà Granda Ospedale Maggiore Policlinico Milano","RECRUITING","Milan","Italy",{"type":32,"coordinates":33},"Point",[34,35],9.18951,45.46427,{"lat":35,"lon":34},[38],{"name":39,"role":22,"phone":10,"phoneExt":10,"email":10},"giancarlo albo, MD",{"type":41,"investigatorFullName":42,"investigatorTitle":43,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Giancarlo Albo","associate professor",[45],{"name":46,"class":47},"National Research Council","AMBIG","100538596",false,"NCT06292897","Using Tissue-based Spatial Data to Understand How Obesity-related Tumor Metabolites Fuel Prostate Cancer Progression","Integrating Tissue-based Spatial Information to Elucidate How Obesity-induced Tumour Metabolites Drive Prostate Cancer Progression","OBESITA'&PCa","Inclusion Criteria:\n\n* affected by prostate cancer\n\nExclusion Criteria:\n\n\\-","MALE","18 Years",{"count":58,"type":59},25,"ESTIMATED","OBSERVATIONAL","Evaluate the protein expression of lactate dehydrogenase enzyme (LDHA) and MCT-1\u002F-4 transporters, involved in lactate synthesis and transport, in prostate carcinoma tissues from severely overweight\u002Fobese (BMI \\> 27.5) and non-severely overweight\u002Fnormoweight (BMI \\\u003C 27.5) patients affected by prostate carcinoma.\n\nii. Characterize the immune infiltrate in the prostate carcinoma of the aforementioned patients.\n\niii. Assess the association between intra-tumoral lactate accumulation (using LDHA and MCT-4 protein expression levels as readouts) and alterations in the tumor immune microenvironment and\u002For deregulation of relevant oncogenic pathways.",[63,64,65,66,67],"Prostate Cancer","Prostate Adenocarcinoma","Prostate Neoplasm","Prostatic Neoplasm","Obesity","2024-02-27",{"date":70,"type":71},"2024-03-05","ACTUAL",{"date":73,"type":71},"2023-03-20",{"date":75,"type":59},"2027-01-15",{"name":5,"class":6},1]