[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100488483":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":19,"locations":28,"responsibleParty":42,"collaborators":10,"id":45,"slug":10,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":10,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":10,"studyType":58,"phases":10,"briefSummary":59,"conditions":60,"keywords":10,"overallStatus":31,"whyStopped":10,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":74},{"fullName":5,"class":6},"Hadassah Medical Organization","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Controls",null,"Healthy women without HPV in their cervical and vaginal sample",{"label":13,"type":10,"description":14,"interventionNames":10},"Women with HPV","Women with HPV, with or without cervical intraepithelial neoplasia or carcinoma",[16],{"name":17,"affiliation":5,"role":18},"Ahinoam Lev Sagie, MD","PRINCIPAL_INVESTIGATOR",[20,24],{"name":17,"role":21,"phone":22,"phoneExt":10,"email":23},"CONTACT","+972-54-4327178","levsagie@netvision.net.il",{"name":25,"role":21,"phone":26,"phoneExt":10,"email":27},"Lilah Tsaitlin Mor, MD","+972-54-7753434","lilah.tsaitlin@gmail.com",[29],{"facility":30,"status":31,"city":32,"state":10,"zip":10,"country":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"Hadassah Medical Center","RECRUITING","Jerusalem","Israel",{"type":35,"coordinates":36},"Point",[37,38],35.21633,31.76904,{"lat":38,"lon":37},[41],{"name":17,"role":21,"phone":22,"phoneExt":10,"email":23},{"type":18,"investigatorFullName":43,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Ahinoam Lev-Sagie","Professor","100488483",false,"NCT05640700","Vaginal Microbiome and HPV Pre-malignant and Cervical Dysplasia","Assessing Personalized Vaginal Microbiome Contributions to HPV-driven Pre-malignant and Malignant Cervical Cancer","Inclusion Criteria:\n\n* Age 25-70\n* Attended the clinic for a Pap smear or colposcopy\n\nExclusion Criteria:\n\n* Patient does not approve sample collection\n* Usage of antibiotics in the month prior to clinic visit\n* Usage of any vaginal preparation or medication in the week prior to sample collection (anti-fungal, spermicides, lubricant etc.)\n* Menstruation\n* Pregnancy",true,"FEMALE","25 Years","70 Years",{"count":56,"type":57},90,"ESTIMATED","OBSERVATIONAL","In this study, the investigators will prospectively collect, analyze and integrate information regarding vaginal microbiome composition and HPV presence in women with cervical pathologies (high-grade CIN and CC) and controls, to construct a large dataset from patients with pre-cancerous cervical lesions and healthy women, to evaluate the personalized contribution of the vaginal microbiome to the CIN-CC sequence.",[61,62,63,64],"Human Papilloma Virus","Vaginal Flora Imbalance","Cancer Cervix Uterus","Cervical Dysplasia","2025-03-15",{"date":67,"type":68},"2025-03-19","ACTUAL",{"date":70,"type":68},"2022-11-09",{"date":72,"type":57},"2025-12-30",{"name":5,"class":6},1]