[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642527":3},{"organization":4,"outcomesModule":7,"designInfo":18,"detailedDescription":17,"studyPopulation":17,"armGroups":26,"interventions":43,"overallOfficials":53,"centralContacts":57,"locations":63,"responsibleParty":85,"collaborators":17,"id":88,"slug":17,"hasResults":89,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":17,"eligibilityCriteria":93,"healthyVolunteers":94,"sex":95,"minAge":96,"maxAge":17,"enrollmentInfo":97,"targetDuration":17,"studyType":100,"phases":101,"briefSummary":103,"conditions":104,"keywords":106,"overallStatus":66,"whyStopped":17,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":123},{"fullName":5,"class":6},"Washington University School of Medicine","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":17},[9],{"measure":10,"description":11,"timeFrame":12},"mJOA - Modified Japanese Orthopedics Association","Measures neurological impairment in degenerative cervical myelopathy","through study completion, an average of 1 year",[14],{"measure":15,"description":16,"timeFrame":12},"Neck Disability Index (NDI)","NDI measures activity limitations associated with neck pain",null,{"allocation":19,"interventionModel":20,"interventionModelDescription":17,"primaryPurpose":21,"observationalModel":17,"timePerspective":17,"maskingInfo":22},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":23,"maskingDescription":17,"whoMasked":24},"SINGLE",[25],"PARTICIPANT",[27,33,38],{"label":28,"type":29,"description":30,"interventionNames":31},"Pre-Post Group (P-P)","EXPERIMENTAL","This group will undergo taVNS for up to 6 weeks before and for 3 months following surgery",[32],"Device: Vagus nerve stimulation (taVNS)",{"label":34,"type":29,"description":35,"interventionNames":36},"Post Group","This group will undergo sham stimulation for up to 6 weeks before surgery. They will receive taVNS for 3 months after surgery",[32,37],"Device: Sham Stimulation",{"label":39,"type":40,"description":41,"interventionNames":42},"Sham Group","SHAM_COMPARATOR","This group will undergo sham stimulation for up to 6 weeks before surgery and for 3 months after surgery. The patients will not know they are not receiving stimulation.",[37],[44,49],{"type":45,"name":46,"description":47,"armGroupLabels":48,"otherNames":17},"DEVICE","Vagus nerve stimulation (taVNS)","Vagus nerve stimulation - clip is attached to ear",[34,28],{"type":45,"name":50,"description":51,"armGroupLabels":52,"otherNames":17},"Sham Stimulation","Clip will be attached to the ear, but no stimulation will be given.",[34,39],[54],{"name":55,"affiliation":5,"role":56},"Wilson Z Ray, MD","PRINCIPAL_INVESTIGATOR",[58],{"name":59,"role":60,"phone":61,"phoneExt":17,"email":62},"Linda Koester, BS","CONTACT","314-362-7368","koesterl@wustl.edu",[64],{"facility":65,"status":66,"city":67,"state":68,"zip":69,"country":70,"countryCode":71,"cosmosGeoPoint":72,"geoPoint":77,"contacts":78},"Washington University","RECRUITING","St Louis","Missouri","63110","United States","US",{"type":73,"coordinates":74},"Point",[75,76],-90.19789,38.62727,{"lat":76,"lon":75},[79,81,83],{"name":80,"role":60,"phone":61,"phoneExt":17,"email":62},"Linda Z Koester, BS",{"name":55,"role":60,"phone":17,"phoneExt":17,"email":82},"rayz@wustl.edu",{"name":84,"role":56,"phone":17,"phoneExt":17,"email":17},"Wilson Z. Ray, MD",{"type":56,"investigatorFullName":86,"investigatorTitle":87,"investigatorAffiliation":5,"oldNameTitle":17,"oldOrganization":17},"Wilson Z. Ray","MD - Principal Investigator","100642527",false,"NCT07660250","Vagus Nerve Stimulation for Myelopathy","Vagus Nerve Stimulation to Improve Post-operative Outcomes of Degenerative Cervical Myelopathy","Inclusion Criteria:\n\n* 18 years of age or older\n* Moderate or severe degenerative cervical myelopathy according to the mJOA\n* Decompression surgery planned\n\nExclusion Criteria:\n\n* • Pregnancy\n\n  * Electrically active implants (e.g. pacemaker)\n  * Known diagnosis of amyotrophic lateral sclerosis, multiple sclerosis, rheumatoid arthritis, concomitant thoracic and\u002For lumbar stenosis, spine tumor, HIV-related myelopathy\n  * Ongoing cancer therapy\n  * Ongoing use of immunomodulating or suppressive medication\n  * Sustained bradycardia with a heartrate \\\u003C50 beats per minute for \\> 5 minutes following admission.\n  * Prior cervical spine surgery",true,"ALL","18 Years",{"count":98,"type":99},36,"ESTIMATED","INTERVENTIONAL",[102],"NA","The objective of this study is to generate preliminary data to establish the feasibility and effectiveness of transauricular vagus nerve stimulation (taVNS) to improve post-operative outcomes of moderate to severe degenerative cervical myelopathy (DCM)",[105],"Degenerative Cervical Myelopathy",[107,108,109,110,111,112,113],"degenerative cervical myelopathy","myelopathy","cervical myelopathy","degenerative myelopathy","vagus nerve","vagus nerve stimulation","ear stimulation","2026-06-15",{"date":116,"type":117},"2026-06-22","ACTUAL",{"date":119,"type":117},"2026-04-14",{"date":121,"type":99},"2028-05",{"name":5,"class":6},1]