[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100524164":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":37,"locations":47,"responsibleParty":73,"collaborators":76,"id":81,"slug":41,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":84,"acronym":41,"eligibilityCriteria":85,"healthyVolunteers":86,"sex":87,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":41,"studyType":93,"phases":94,"briefSummary":96,"conditions":97,"keywords":41,"overallStatus":50,"whyStopped":41,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Brigham and Women's Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active cerebellar rTMS","ACTIVE_COMPARATOR","Cerebellar targeted iTBS",[13],"Device: Repetitive Transcranial Magnetic Stimulation (rTMS)",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham cerebellar rTMS","SHAM_COMPARATOR","Cerebellar targeted sham iTBS",[19],"Device: Sham repetitive Transcranial Magnetic Stimulation (rTMS)",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Repetitive Transcranial Magnetic Stimulation (rTMS)","rTMS is a technique of TMS that allows for selective external manipulation of neural activity in a non-invasive manner. During rTMS a rapidly changing current is passed through an insulated coil placed against the scalp. This generates a temporary magnetic field, which in turn induces electrical current in neurons and allows for modulation of neural circuitry.\n\nIntermittent theta burst stimulation (iTBS) consisting of 2 s trains of 3 pulses at 50 Hz, repeated at 5 Hz, every 10s for a total of 600 pulses (82), will be applied to the target. Cerebellar stimulation will be applied to the targets at 100% of aMT or 35% maximal stimulator output, whichever is higher.",[9],[27],"iTBS",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Sham repetitive Transcranial Magnetic Stimulation (rTMS)","rTMS is a technique of TMS that allows for selective external manipulation of neural activity in a non-invasive manner. During rTMS a rapidly changing current is passed through an insulated coil placed against the scalp. This generates a temporary magnetic field, which in turn induces electrical current in neurons and allows for modulation of neural circuitry.\n\nIntermittent theta burst stimulation (iTBS) consisting of 2 s trains of 3 pulses at 50 Hz, repeated at 5 Hz, every 10s for a total of 600 pulses (82), will be applied to the target. Cerebellar stimulation will be applied to the targets at 100% of aMT or 35% maximal stimulator output, whichever is higher.\n\nSham is achieved by using a coil with a magnetic shield preventing magnetic field from reaching the head.",[15],[27],[34],{"name":35,"affiliation":5,"role":36},"Laura Holsen, PhD","PRINCIPAL_INVESTIGATOR",[38,43],{"name":35,"role":39,"phone":40,"phoneExt":41,"email":42},"CONTACT","617-525-8772",null,"lholsen@bwh.harvard.edu",{"name":44,"role":39,"phone":45,"phoneExt":41,"email":46},"Mark Halko, PhD","617-855-2415","mhalko@mclean.harvard.edu",[48,63],{"facility":49,"status":50,"city":51,"state":52,"zip":53,"country":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"McLean Hospital","RECRUITING","Belmont","Massachusetts","02478","United States",{"type":56,"coordinates":57},"Point",[58,59],-71.17867,42.39593,{"lat":59,"lon":58},[62],{"name":44,"role":39,"phone":45,"phoneExt":41,"email":46},{"facility":5,"status":50,"city":64,"state":52,"zip":65,"country":54,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"Boston","02120",{"type":56,"coordinates":67},[68,69],-71.05977,42.35843,{"lat":69,"lon":68},[72],{"name":35,"role":39,"phone":40,"phoneExt":41,"email":42},{"type":36,"investigatorFullName":74,"investigatorTitle":75,"investigatorAffiliation":5,"oldNameTitle":41,"oldOrganization":41},"Laura M Holsen","Associate Professor of Psychiatry",[77,79],{"name":78,"class":6},"Mclean Hospital",{"name":80,"class":6},"Beth Israel Deaconess Medical Center","100524164",false,"NCT06105164","Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans","Inclusion Criteria:\n\n* Healthy individuals aged 18 to 65\n* BMI of 20-35.0 kg\u002Fm2\n* Normal or corrected-to-normal vision\n* Good general health\n* Ability to understand and willingness to sign written informed consent document\n\nExclusion Criteria:\n\n* Current and\u002For past medical conditions\n* Current and\u002For past eating disorder\n* On a restricted diet and\u002For taking weight loss medication(s)\n* History of bariatric surgery\n* Weight fluctuation \\>3% in past 3 months\n* Recent history of illicit recreational drug abuse\n* Current nicotine use\n* Intellectual disability\n* Conditions that might result in increased risks of side effects or complications from TMS or MRI",true,"ALL","18 Years","65 Years",{"count":91,"type":92},150,"ESTIMATED","INTERVENTIONAL",[95],"NA","This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study satiety in healthy individuals.\n\nTMS is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the brain. The magnetic field is produced by a coil that is held next to the scalp. In this study, the investigators will be stimulating the brain to learn more about the role of the cerebellum in satiety.",[98,99],"Appetitive Behavior","Obesity","2025-12-01",{"date":102,"type":103},"2025-12-05","ACTUAL",{"date":105,"type":103},"2024-12-05",{"date":107,"type":92},"2029-08",{"name":5,"class":6},2]