[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100468774":3},{"organization":4,"outcomesModule":7,"designInfo":25,"detailedDescription":31,"studyPopulation":24,"armGroups":32,"interventions":49,"overallOfficials":24,"centralContacts":24,"locations":61,"responsibleParty":82,"collaborators":24,"id":86,"slug":24,"hasResults":87,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":24,"eligibilityCriteria":91,"healthyVolunteers":87,"sex":92,"minAge":93,"maxAge":94,"enrollmentInfo":95,"targetDuration":24,"studyType":98,"phases":99,"briefSummary":101,"conditions":102,"keywords":104,"overallStatus":64,"whyStopped":24,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},{"fullName":5,"class":6},"Virginia Polytechnic Institute and State University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":24},[9],{"measure":10,"description":11,"timeFrame":12},"change in proportion correct on the 'N-arm bandit learning task'","change in proportion correct on 'N-arm bandit reinforcement learning task' from study entrance to study exit","study entrance to study exit, an average of 12 weeks",[14,18,21],{"measure":15,"description":16,"timeFrame":17},"change in depression symptoms (Beck Depression Inventory)","change in depression symptoms from study entrance to study exit","study entrance to exit, an average of 12 weeks",{"measure":19,"description":20,"timeFrame":17},"change in anxiety symptoms (anxiety subscale; Mood and Anxiety Symptom Questionnaire)","change in anxiety symptoms from study entrance to study exit",{"measure":22,"description":23,"timeFrame":17},"change in anhedonia symptoms (anhedonia subscale; Mood and Anxiety Symptom Questionnaire)","change in anhedonia symptoms from study entrance to study exit",null,{"allocation":26,"interventionModel":27,"interventionModelDescription":24,"primaryPurpose":28,"observationalModel":24,"timePerspective":24,"maskingInfo":29},"RANDOMIZED","PARALLEL","BASIC_SCIENCE",{"masking":30,"maskingDescription":24,"whoMasked":24},"NONE","This study tests relationships among neural and behavioral valuation mechanisms, and how these mechanisms change (or not) over time, with task instructions, and following cognitive behavior therapy.",[33,39,44],{"label":34,"type":35,"description":36,"interventionNames":37},"Cognitive behavioral therapy","ACTIVE_COMPARATOR","cognitive behavioral therapy for depression, anxiety, and\u002For anhedonia",[38],"Behavioral: cognitive behavioral therapy",{"label":40,"type":35,"description":41,"interventionNames":42},"Valuation with instruction","repeat laboratory sessions of a reward\u002Floss learning computer game with specific instructions",[43],"Behavioral: valuation with instruction",{"label":45,"type":35,"description":46,"interventionNames":47},"Valuation without instruction","repeat laboratory sessions of a reward\u002Floss learning computer game without specific instructions",[48],"Behavioral: valuation without instruction",[50,54,58],{"type":51,"name":52,"description":52,"armGroupLabels":53,"otherNames":24},"BEHAVIORAL","cognitive behavioral therapy",[34],{"type":51,"name":55,"description":56,"armGroupLabels":57,"otherNames":24},"valuation with instruction","repeat laboratory sessions of computerized learning game",[40],{"type":51,"name":59,"description":56,"armGroupLabels":60,"otherNames":24},"valuation without instruction",[45],[62],{"facility":63,"status":64,"city":65,"state":66,"zip":67,"country":68,"countryCode":69,"cosmosGeoPoint":70,"geoPoint":75,"contacts":76},"Fralin Biomedical Research Institute at Virginia Tech Carilion","RECRUITING","Roanoke","Virginia","24014","United States","US",{"type":71,"coordinates":72},"Point",[73,74],-79.94143,37.27097,{"lat":74,"lon":73},[77],{"name":78,"role":79,"phone":80,"phoneExt":24,"email":81},"Pearl Chiu, PhD","CONTACT","540-526-2032","chiup@vtc.vt.edu",{"type":83,"investigatorFullName":84,"investigatorTitle":85,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Pearl Chiu","Professor","100468774",false,"NCT05384158","Valuation in Depressed Mood, Anhedonia, and Anxiety","Evaluating Overlap and Distinctiveness in Neurocomputational Loss and Reward Elements of the RDoC Matrix","Inclusion Criteria:\n\n* mood, anxiety, or anhedonia symptoms that affect functioning; fluent in English; able to see computer display; able to perform simple computer games.\n\nExclusion Criteria:\n\n* history of seizure disorder, stroke, or head injury with more than 10 minutes of unconsciousness; hormone disorder; electroconvulsive therapy within 5 years; history of chemotherapy for cancer; current pregnancy; contraindications to MRI","ALL","25 Years","50 Years",{"count":96,"type":97},252,"ESTIMATED","INTERVENTIONAL",[100],"NA","This study examines how people respond to rewards and losses, and the extent to which these responses are linked or distinct among people experiencing depressed mood, anhedonia, and\u002For anxiety.",[103],"Neurobehavioral Components of Reward and Loss Valuation",[105,106,107],"depression","anxiety","anhedonia","2025-09-02",{"date":110,"type":111},"2025-09-09","ACTUAL",{"date":113,"type":111},"2021-08-01",{"date":115,"type":97},"2026-07",{"name":5,"class":6},1]