[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636287":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":10,"centralContacts":43,"locations":49,"responsibleParty":61,"collaborators":10,"id":64,"slug":10,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":10,"studyType":77,"phases":10,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":84,"whyStopped":10,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"National Institute of Cardiology, Laranjeiras, Brazil","OTHER_GOV",[8,18],{"label":9,"type":10,"description":11,"interventionNames":12},"elderly (60-80 years)",null,"Evaluation of systemic microcirculation",[13,14,15,16,17],"Diagnostic Test: Laser Speckle Contrast Imaging","Diagnostic Test: Handgrip Dynamometry (Muscle Strength)","Diagnostic Test: Sit-to-Stand Test (5-Times Sit-to-Stand - 5STS)","Diagnostic Test: Single-Leg Balance Test","Diagnostic Test: Assessment of Global Cognitive Function",{"label":19,"type":10,"description":11,"interventionNames":20},"very elderly (>80)",[13,14,15,16,17],[22,27,31,35,39],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":10},"DIAGNOSTIC_TEST","Laser Speckle Contrast Imaging","Investigation of Systemic Endothelial Microvascular Function",[9,19],{"type":23,"name":28,"description":29,"armGroupLabels":30,"otherNames":10},"Handgrip Dynamometry (Muscle Strength)","Serving as a marker of systemic muscle strength and sarcopenia.",[9,19],{"type":23,"name":32,"description":33,"armGroupLabels":34,"otherNames":10},"Sit-to-Stand Test (5-Times Sit-to-Stand - 5STS)","This test will assess the strength and power of the lower limbs.",[9,19],{"type":23,"name":36,"description":37,"armGroupLabels":38,"otherNames":10},"Single-Leg Balance Test","Failure to maintain the position (to stand on one leg) for at least 10 seconds will be correlated as a marker of frailty and risk of falls.",[9,19],{"type":23,"name":40,"description":41,"armGroupLabels":42,"otherNames":10},"Assessment of Global Cognitive Function","Overall cognitive function will be assessed using the Mini-Mental State Examination.",[9,19],[44],{"name":45,"role":46,"phone":47,"phoneExt":10,"email":48},"Eduardo Tibirica, MD, PhD","CONTACT","+55-21-99914-6075","etibi@uol.com.br",[50],{"facility":51,"status":10,"city":52,"state":10,"zip":53,"country":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":10},"Eduardo Tibiriçá","Rio de Janeiro","22240006","Brazil",{"type":56,"coordinates":57},"Point",[58,59],-43.18223,-22.90642,{"lat":59,"lon":58},{"type":62,"investigatorFullName":45,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Senior Researcher","100636287",false,"NCT07563725","Vascular Aging and Microcirculation: Physiological Aspects of Vascular Aging in the Elderly Population (VAMP-Aging)","VAMP-Aging","Inclusion Criteria:\n\n* Absence of symptoms and history of cardiovascular and cerebrovascular diseases.\n* Baseline blood pressure levels within the normal range (\\\u003C 140\u002F90 mmHg, according to WHO criteria) and absence of use of antihypertensive medications.\n\nExclusion Criteria:\n\n* Diabetes Mellitus: Fasting blood glucose ≥ 126 mg\u002FdL or use of hypoglycemic agents.\n* Smoking: Active or quit less than 5 years ago.\n* Inflammatory Diseases: Autoimmune diseases, active neoplasms, or acute infectious processes.\n* Surgery or trauma in the last 60 days.\n* Renal Dysfunction: Chronic renal failure (estimated by eGFR \\\u003C 60 mL\u002Fmin\u002F1.73m²).\n* Medication Use: Chronic use of corticosteroids, immunosuppressants, or drugs with direct action on vascular reactivity (e.g., continuous use of nitrates).",true,"ALL","60 Years","100 Years",{"count":75,"type":76},62,"ESTIMATED","OBSERVATIONAL","Rising life expectancy worldwide challenges public health due to increased cardiovascular disease linked to vascular aging, where microvascular dysfunction serves as an early indicator of system-wide inflammation, or \"inflammaging\". The proposed study aims to validate non-invasive, high-resolution techniques, such as Laser Speckle Contrast Imaging, to identify early endothelial senescence biomarkers and map their correlation with metabolic, inflammatory, and anthropometric profiles to advance personalized, preventive translational medicine.",[80],"Aging Problems",[82,24,83],"microcirculation","vascular aging","NOT_YET_RECRUITING","2026-04-29",{"date":87,"type":88},"2026-05-04","ACTUAL",{"date":90,"type":76},"2026-06",{"date":92,"type":76},"2029-12",{"name":5,"class":6},1]