About this trial

Comparison of the efficacy and safety of three vasoactive agents-dopamine, norepinephrine, and epinephrine-in the treatment of patients with pulmonary hypertension crisis: prospective, randomised controlled trial monitored by haemodynamic monitoring

Eligibility criteria

Qualifiers

Age > 18 years old;

Signed informed consent form;

Confirmed diagnosis of arterial pulmonary hypertension (PAH) and/or chronic thromboembolic pulmonary hypertension (CTEPH);

Presenting with manifestations of pulmonary hypertensive crisis;

Disqualifiers

At SCAI stage D or stage E ;

Patients who only receive a diagnosis but no treatment in the hospital;

Uncontrolled hyperthyroidism;

Complicated with angle-closure glaucoma;

Trial design

Treatments tested in this trial

  • Norepinephrine
  • Dopamine
  • Epinephrine

Treatment groups

75 Participants
are divided into 3 treatment groups

Locations

3
Chinese Academy of Medical Sciences, Fuwai Hospital10037, BeijingBeijing Municipality, China
Guangdong Provincial People's Hospital510180, GuangzhouGuangdong, China
Zhongnan Hospital of Wuhan University430072, WuhanWuhan, China

Sponsors and collaborators

China National Center for Cardiovascular Diseases

Lead sponsor

Chinese Academy of Medical Sciences, Fuwai Hospital

Sponsor institution