[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616085":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":18,"responsibleParty":32,"collaborators":10,"id":36,"slug":10,"hasResults":37,"nctId":38,"briefTitle":39,"officialTitle":39,"acronym":40,"eligibilityCriteria":41,"healthyVolunteers":42,"sex":43,"minAge":44,"maxAge":10,"enrollmentInfo":45,"targetDuration":48,"studyType":49,"phases":10,"briefSummary":50,"conditions":51,"keywords":56,"overallStatus":64,"whyStopped":10,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":74},{"fullName":5,"class":6},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"OSA patients after an MMA",null,"Patients with obstructive sleep apnea (OSA) who underwent a maxillomandibular advancement (MMA)",[13],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Misha Tan, PhD student","CONTACT","+31613125803","m.l.tan@amsterdamumc.nl",[19],{"facility":20,"status":10,"city":21,"state":22,"zip":10,"country":23,"cosmosGeoPoint":24,"geoPoint":29,"contacts":30},"Amsterdam UMC","Amsterdam","North Holland","Netherlands",{"type":25,"coordinates":26},"Point",[27,28],4.88969,52.37403,{"lat":28,"lon":27},[31],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},{"type":33,"investigatorFullName":34,"investigatorTitle":35,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Prof. dr. J. de Lange, MD DMD","Prof.dr. Jan de Lange, Head of Department Oral and Maxillofacial Surgery (Amsterdam UMC)","100616085",false,"NCT07301021","Velopharyngeal Insufficiency After Maxillomandibular Advancement Osteotomy in Obstructive Sleep Apnea Patients","VPIMMA","Inclusion Criteria:\n\n* Age \\> 18 years\n* Mild to severe OSA\n* Indication for MMA for OSA treatment\n\nExclusion Criteria:\n\n* patients who underwent other adjunctive procedures at the time of MMA (e.g., multipiece le Fort osteotomy, TMJ reconstruction\n* Previous history of orthognathic surgery\n* Previous history of orthognathic surgery\n* Previous history of oropharyngeal surgery (UPPP or multi-level surgery)\n* Cleft palate and syndromic patients\n* Neuromusculair diseases which causes VPI, dysphagia or dysarthria\n* Incapacity",true,"ALL","18 Years",{"count":46,"type":47},28,"ESTIMATED","2 Years","OBSERVATIONAL","The aim of this study is to gain insight into the development of velopharyngeal insufficiency (VPI) in patients who have undergone maxillomandibular advancement osteotomy (MMA) as a treatment for obstructive sleep apnea syndrome (OSAS). A speech therapist evaluates nasality, speech, and swallowing before and after the surgery.",[52,53,54,55],"Velopharyngeal Insufficiency","Swallowing","Nasality","Speech",[57,58,59,60,61,62,63],"maxillomandibular advancement","obstructive sleep apnea","velopharyngeal insufficiency","speech therapy","swallowing","nasality","speech","NOT_YET_RECRUITING","2026-03-18",{"date":67,"type":68},"2026-03-20","ACTUAL",{"date":70,"type":47},"2026-05-01",{"date":72,"type":47},"2027-12-01",{"name":5,"class":6},1]