[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100495317":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":34,"locations":39,"responsibleParty":56,"collaborators":25,"id":59,"slug":25,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":25,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":25,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":25,"overallStatus":42,"whyStopped":25,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Harvard Medical School (HMS and HSDM)","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Connective tissue graft","ACTIVE_COMPARATOR","Autogenous connective tissue graft harvested from the palate as a free gingival graft and then de-epithelialized",[13],"Procedure: Vertical soft tissue augmentation",{"label":15,"type":16,"description":17,"interventionNames":18},"Dermal matrix + EMD","EXPERIMENTAL","Acellular dermal matrix and enamel matrix derivative",[13],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Vertical soft tissue augmentation","Vertical soft tissue augmentation with autogenous connective tissue graft (CTG)",[9],null,{"type":21,"name":22,"description":27,"armGroupLabels":28,"otherNames":25},"Vertical soft tissue augmentation with acellular dermal matrix (ADM) and enamel matrix derivative (EMD)",[15],[30],{"name":31,"affiliation":32,"role":33},"Lorenzo Tavelli, DDS, MS","Harvard School of Dental Medicine, Boston, USA","PRINCIPAL_INVESTIGATOR",[35],{"name":31,"role":36,"phone":37,"phoneExt":25,"email":38},"CONTACT","734-604-4364","lorenzo_tavelli@hsdm.harvard.edu",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Harvard School of Dental Medicine","RECRUITING","Boston","Massachusetts","02115","United States",{"type":48,"coordinates":49},"Point",[50,51],-71.05977,42.35843,{"lat":51,"lon":50},[54],{"name":31,"role":36,"phone":55,"phoneExt":25,"email":38},"7346044364",{"type":33,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Lorenzo Tavelli","Assistant Professor","100495317",false,"NCT05729607","Vertical Soft Tissue Augmentation With CTG vs ADM","Vertical Soft Tissue Augmentation With Dermal Matrix and Enamel Matrix Derivative vs Connective Tissue Graft for the Treatment of Peri-implant Soft Tissue Dehiscences in the Esthetic Zone: A Randomized, Controlled, Clinical, Trial","Inclusion criteria:\n\n* Age ≥ 18 years\n* Periodontally and systemically healthy\n* Full-mouth plaque score and full-mouth bleeding score ≤ 20% (measured at four sites per tooth)\n* Presence of single functional dental implant in the anterior with a PSTD\n* Implants diagnosed as healthy (Berglundh et al., 2018)\n\nExclusion criteria are:\n\n* Contraindications for surgery\n* Systemic condition (e.g. diabetes mellitus, HIV, cancer, etc) that could compromise wound healing\n* Patients pregnant or attempting to get pregnant (self-reported)\n* Untreated periodontitis\n* Untreated peri-implant mucositis or peri-implantitis (Berglundh et al., 2018)\n* Smoking, defined as self-reported daily habit. Occasional smokers won't be excluded\n* History of soft tissue grafting at the implant site within the last 6 months",true,"ALL","18 Years","99 Years",{"count":70,"type":71},28,"ESTIMATED","INTERVENTIONAL",[74],"NA","The study aims at comparing two different approaches for vertical soft tissue augmentation at implant sites exhibiting soft tissue dehiscences: autogenous connective tissue graft vs acellular dermal matrix + enamel matrix derivative",[77],"Implant Complication","2025-09-12",{"date":80,"type":81},"2025-09-18","ACTUAL",{"date":83,"type":81},"2023-05-26",{"date":85,"type":71},"2027-11-27",{"name":5,"class":6},1]