[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100551316":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":17,"locations":25,"responsibleParty":38,"collaborators":7,"id":40,"slug":7,"hasResults":41,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":41,"sex":47,"minAge":48,"maxAge":7,"enrollmentInfo":49,"targetDuration":7,"studyType":52,"phases":7,"briefSummary":53,"conditions":54,"keywords":57,"overallStatus":28,"whyStopped":7,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":70},{"fullName":5,"class":6},"Assistance Publique - Hôpitaux de Paris","OTHER",null,[9,13],{"name":10,"affiliation":11,"role":12},"Claude CAPRON, MD, PhD","Laboratory of Immunology, Ambroise Paré hospital - APHP","PRINCIPAL_INVESTIGATOR",{"name":14,"affiliation":15,"role":16},"Fernando REAL, PhD","Center for Infection and Immunity of Lille, INSERM U1019 - CNRS UMR9017, Institut Pasteur de Lille","STUDY_DIRECTOR",[18,22],{"name":10,"role":19,"phone":20,"phoneExt":7,"email":21},"CONTACT","+ 33 01 49 09 58 47","claude.capron@aphp.fr",{"name":14,"role":19,"phone":23,"phoneExt":7,"email":24},"+ 33 03 20 87 12 01","fernando.real@cnrs.fr",[26],{"facility":27,"status":28,"city":29,"state":7,"zip":30,"country":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":7},"Hematology and interne medicine department, Ambroise Paré hospital - APHP","RECRUITING","Boulogne-Billancourt","92100","France",{"type":33,"coordinates":34},"Point",[35,36],2.24128,48.83545,{"lat":36,"lon":35},{"type":39,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100551316",false,"NCT06458504","Viral Infection of HSPC Impacts Hematopoiesis","Virus-induced Immunosuppression Via Infection of Hematopoietic Progenitors","MEGAHOST","Inclusion Criteria:\n\nHIV patients :\n\n* HIV-positive patients with a negative or positive viral load.\n* managed at Ambroise Paré Hospital.\n* patients with a bone marrow biopsy or myelogram performed as part of their care.\n\nHealthy subjects without HIV - patients with a BM biopsy or myelogram performed as part of their care for a suspected hematological pathology.\n\nManagement at Ambroise Paré Hospital.\n\nExclusion Criteria:\n\n\\-","ALL","18 Years",{"count":50,"type":51},45,"ESTIMATED","OBSERVATIONAL","We propose to demonstrate that HIV-1 and SARS-CoV-2 are capable of targeting long-lived HSPC with self-renewal capacities. These progenitors, thus transformed into host cells, can give rise to a durable source of infected cells with an impact on hematopoiesis.",[55,56],"HIV-1","SARS-CoV-2",[55,56,58,59,60],"Hematopoietic Progenitors","Virus-induced","Immunosuppression","2025-03-17",{"date":63,"type":64},"2025-03-20","ACTUAL",{"date":66,"type":64},"2024-10-25",{"date":68,"type":51},"2026-03",{"name":5,"class":6},1]