VITAL: Vaccination, Immunity, Time-restricted Eating, Aging and Lifestyle
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age60-85
SponsorCharite University, Berlin, Germany
About this trial
The aim of this study is to investigate the effects of a four-week time-restricted eating (TRE) intervention on autophagy, immune function, and vaccine response to a seasonal influenza and COVID-19 vaccines in older healthy subjects.
Eligibility criteria
Qualifiers
Male and female participants, enrolled in a 1:1 ratio
Age 60-85 years
Body mass index (BMI) 20-35 kg/m²
Capacity to give informed consent
Disqualifiers
Any vaccination (especially influenza and/or COVID-19) within 6 months before the intervention start
Vaccinations not related to the study, administered during the study period from V0 to V4
History of influenza infection within 6 months prior to initiation of the study intervention
History of severe adverse reactions to prior vaccinations
Trial design
Treatments tested in this trial
- TRE: Time-restricted eating
Treatment groups
24 Participants
are divided into 2 treatment groupsLocations
1Clinical Research Unit, Experimental & Clinical Research Center, Campus Buch, Charité13125, Berlin Germany
Sponsors and collaborators
Charite University, Berlin, Germany
Lead sponsor
Max Delbrück Center for Molecular Medicine (MDC), Berlin
Collaborator
Labor Berlin, Germany
Collaborator
Experimental & Clinical Research Center Berlin
Collaborator
University of Oxford
Collaborator
University of Cologne
Collaborator
Source ClinicalTrials.gov