[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100619723":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":34,"locations":43,"responsibleParty":74,"collaborators":78,"id":88,"slug":25,"hasResults":89,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":89,"sex":95,"minAge":96,"maxAge":97,"enrollmentInfo":98,"targetDuration":25,"studyType":101,"phases":102,"briefSummary":104,"conditions":105,"keywords":108,"overallStatus":112,"whyStopped":25,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":122},{"fullName":5,"class":6},"Nanjing Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Vitamin B supplementation","EXPERIMENTAL","perioperative supplementation with Compound Vitamin B tablets, once daily from 3 days before surgery to 6 months after surgery",[13],"Drug: Compound Vitamin B tablet",{"label":15,"type":16,"description":17,"interventionNames":18},"Control","PLACEBO_COMPARATOR","perioperative supplementation with oral placebo, once daily from 3 days before surgery to 6 months after surgery",[19],"Drug: Control",[21,26],{"type":22,"name":23,"description":11,"armGroupLabels":24,"otherNames":25},"DRUG","Compound Vitamin B tablet",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"perioperative supplementation with placebo, once daily from 3 days before surgery to 6 months after surgery",[15],[30],{"name":31,"affiliation":32,"role":33},"Guo-liang Fan","Shanghai East Hospital","STUDY_CHAIR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Hong Liu, MD","CONTACT","02568303101","dr.hongliu@foxmail.com",{"name":41,"role":37,"phone":25,"phoneExt":25,"email":42},"Guo-laing Fan, MD","smartmanliang@sina.com",[44,62],{"facility":45,"status":25,"city":46,"state":47,"zip":25,"country":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Shanghai East Hospital Tongji University","Shanghai","DR","China",{"type":50,"coordinates":51},"Point",[52,53],121.45806,31.22222,{"lat":53,"lon":52},[56,59,60],{"name":57,"role":37,"phone":58,"phoneExt":25,"email":42},"Guo-liang Fan, MD","18622738357",{"name":41,"role":37,"phone":25,"phoneExt":25,"email":42},{"name":57,"role":61,"phone":25,"phoneExt":25,"email":25},"SUB_INVESTIGATOR",{"facility":63,"status":25,"city":64,"state":25,"zip":25,"country":48,"cosmosGeoPoint":65,"geoPoint":69,"contacts":70},"The First Affiliated Hospital of Nanjing Medical University","Nanjing",{"type":50,"coordinates":66},[67,68],118.77778,32.06167,{"lat":68,"lon":67},[71,72,73],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},{"name":41,"role":37,"phone":25,"phoneExt":25,"email":42},{"name":36,"role":61,"phone":25,"phoneExt":25,"email":25},{"type":75,"investigatorFullName":76,"investigatorTitle":77,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Hong Liu","Principal Investigator of Department of Cardiovascular Surgery",[79,81,83,85,87],{"name":80,"class":6},"The First Affiliated Hospital with Nanjing Medical University",{"name":82,"class":6},"West China Hospital",{"name":84,"class":6},"The First Affiliated Hospital of Guangzhou Medical University",{"name":86,"class":6},"The Affiliated Hospital of Qingdao University",{"name":32,"class":6},"100619723",false,"NCT07348328","Vitamin B Supplementation for Patients Undergoing Cardiovascular Surgery","Vitamin B Supplementation for Patients Undergoing Cardiovascular Surgery: A Randomized Controlled Trial","PANDA XII","Inclusion Criteria:\n\n* Aged 18-80 years, regardless of gender;\n* Scheduled to receive cardiovascular surgery at the research center, including coronary artery bypass grafting (CABG), cardiac valve replacement\u002Frepair, and great vessel surgery;\n* Preoperative assessment indicates that the patient is expected to complete the 6-month postoperative follow-up;\n* The patient or their authorized agent signs a written informed consent form.\n\nExclusion Criteria:\n\n* Regular supplementation with Compound Vitamin B (daily dose ≥ 1.5 times the recommended dietary allowance) or separate supplementation with folic acid, vitamin B6, or B12 within 3 months before surgery;\n* Severe hepatic or renal insufficiency (liver function: ALT\u002FAST \\> 3 times the upper limit of normal, or total bilirubin \\> 2 times the upper limit of normal; renal function: serum creatinine \\> 265 μmol\u002FL, or requiring long-term dialysis treatment);\n* Malignant tumors, severe hematological diseases (e.g., megaloblastic anemia, aplastic anemia), severe malnutrition (albumin \\\u003C 25 g\u002FL);\n* History of allergy to Compound Vitamin B preparations or placebo components; Pregnant women, lactating women, or those planning to become pregnant during the study period;\n* Currently participating in other interventional clinical trials;\n* Moderate to severe cognitive impairment without a fixed caregiver, unable to cooperate with treatment and follow-up;\n* Preoperatively diagnosed with severe infection, septicemia, or septic shock.","ALL","18 Years","80 Years",{"count":99,"type":100},1000,"ESTIMATED","INTERVENTIONAL",[103],"NA","This study is a multicenter, randomized controlled, double-blind, placebo-controlled parallel trial designed to evaluate the effect of perioperative supplementation with Compound Vitamin B on patients undergoing cardiovascular surgery. A total of 1,000 patients aged 18-80 years who are scheduled to receive cardiovascular surgeries such as coronary artery bypass grafting (CABG) and valve replacement will be enrolled. They will be randomly assigned at a 1:1 ratio to either the experimental group (perioperative supplementation with Compound Vitamin B tablets, once daily from 3 days before surgery to 6 months after surgery) or the control group (oral placebo), with both groups receiving standardized perioperative treatment.",[106,107],"Cardiovascular Surgical Procedures","Major Adverse Cardiovascular Events (MACE)",[109,110,111],"Compound Vitamin B","Cardiovascular Surgery","Major Adverse Cardiovascular Events","NOT_YET_RECRUITING","2026-01-09",{"date":115,"type":116},"2026-01-16","ACTUAL",{"date":118,"type":100},"2026-02-01",{"date":120,"type":100},"2027-12-31",{"name":5,"class":6},2]