[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100589523":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":38,"locations":49,"responsibleParty":70,"collaborators":74,"id":75,"slug":74,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":74,"eligibilityCriteria":79,"healthyVolunteers":76,"sex":80,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":74,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":74,"overallStatus":52,"whyStopped":74,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Asian Institute of Gastroenterology, India","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"To assess the efficacy of vonapraprazon 20mg better than esomeprazole drug","ACTIVE_COMPARATOR","healing rate will be checked during endoscopy at 8 weeks",[13],"Drug: Vonoprazan",{"label":15,"type":16,"description":17,"interventionNames":18},"To see the healing rate of grade B esophagitis","PLACEBO_COMPARATOR","healing rate will be checked during endoscopy at 8 weeks in patients receiving esomeprazole 40mg",[19],"Drug: Esomeprazole 40mg",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Vonoprazan","a potassium-competitive acid blocker (P-CAB), offers superior acid suppression and may provide enhanced healing in post-POEM reflux esophagitis.",[9],[27],"per oral endoscopy myotomy",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Esomeprazole 40mg","It is a proton pump inhibitor which reduces the excessive acid secretion in the stomach and it heals grade B esophagitis (\\>5mm ulcer between two mucosal folds in esophagus)",[15],[27],[34],{"name":35,"affiliation":36,"role":37},"Mohan Dr Ramchandani, MD DM","Asian Institute of Gastroenterology","STUDY_DIRECTOR",[39,45],{"name":40,"role":41,"phone":42,"phoneExt":43,"email":44},"Rajesh Goud Mr Maragoni, M.Pharm","CONTACT","04023378888","312","rajeshgoud761@gmail.com",{"name":46,"role":41,"phone":42,"phoneExt":47,"email":48},"Zaheer Nabi Dr Mohammed, MD DNB","427","zaheernabi1978@gmail.com",[50],{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"Asian Institute of Gastroenterology \u002FAig Hospitals","RECRUITING","Hyderabad","Telangana","500082","India",{"type":58,"coordinates":59},"Point",[60,61],78.45636,17.38405,{"lat":61,"lon":60},[64,67],{"name":65,"role":41,"phone":42,"phoneExt":66,"email":48},"ZAHEER DR NABI, MBBS MDDNB","503",{"name":68,"role":41,"phone":42,"phoneExt":69,"email":44},"Rajesh Goud Mr Maragoni, M.Pharm MBA","301",{"type":71,"investigatorFullName":72,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":74,"oldOrganization":74},"PRINCIPAL_INVESTIGATOR","Mohan Ramchandani","Director",null,"100589523",false,"NCT06955520","Vonaprazan Versus Esomeprazole for Healing of LA Grade B or Higher Esophagitis After POEM","Inclusion Criteria:\n\n* Age ≥18 years\n* History of POEM for achalasia\n* Endoscopic confirmation of LA grade B, C, or D reflux esophagitis at 3 months post-POEM\n* GERD symptoms (heartburn, regurgitation) for ≥4 weeks\n* Willingness to provide informed consent and comply with study procedures\n\nExclusion Criteria:\n\n* History of prior anti-reflux surgery\n* Presence of Barrett's esophagus, esophageal stricture, or malignancy\n* Severe gastroparesis or esophageal motility disorder unrelated to achalasia\n* Pregnancy or breastfeeding\n* Severe hepatic or renal impairment (ALT\u002FAST \\>3× ULN, eGFR \\\u003C30 mL\u002Fmin)\n* Regular use of NSAIDs, steroids, or anticoagulants affecting esophageal healing","ALL","18 Years","75 Years",{"count":84,"type":85},300,"ESTIMATED","INTERVENTIONAL",[88],"NA","Peroral Endoscopic Myotomy (POEM) is a well-established treatment for achalasia; however, it is frequently associated with gastroesophageal reflux disease (GERD), with many patients developing LA grade B or higher esophagitis. Proton pump inhibitors (PPIs) like Esomeprazole are the standard treatment, but Vonaprazan, a potassium-competitive acid blocker (P-CAB), offers superior acid suppression and may provide enhanced healing in post-POEM reflux esophagitis.\n\nPrimary Objective:\n\n• To compare the healing rates of LA grade B or higher reflux esophagitis at 8 weeks in patients receiving Vonaprazan 20 mg versus Esomeprazole 40 mg.\n\nSecondary Objectives\n\n* To assess improvement in reflux symptoms using the GERD-Q score at 8 weeks.\n* To evaluate the incidence of adverse events in each treatment group.",[91],"GERD","2026-04-22",{"date":94,"type":95},"2026-04-27","ACTUAL",{"date":97,"type":95},"2025-04-30",{"date":99,"type":85},"2028-12-25",{"name":5,"class":6},1]