V/Q Matching Variations With PEEP in ARDS According to Compliance-based Phenotypes (France)
ConditionARDS
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity Hospital, Angers
About this trial
This study aim to compare the effect of Positive End Expiratory Pressure (PEEP) on ventilation/perfusion mismatch in two phenotypes of patients with moderate-to-severe Acute Respiratory Distress Syndrome (ARDS), characterized by their respiratory system elastance (Ers). Ventilation/perfusion mismatch will be assessed by Electrical Impedance Tomography (EIT).
Eligibility criteria
Qualifiers
intubated patients with moderate and severe ARDS (Berlin definition, PaO2/FiO2 ≤200 mmHg at PEEP 5 cmH2O)
undergoing deep sedation
on controlled mechanical ventilation
between 24 hours and 5 days after intubation.
Disqualifiers
age <18 years old; pregnancy
patient undergoing legal protection
contra-indications to EIT (e. g. severe chest trauma or wounds)
pneumothorax; patient undergoing ECMO
Trial design
Treatments tested in this trial
- PEEP increase
- PEEP decrease
Treatment groups
50 Participants
are divided into 2 treatment groupsLocations
1Angers Hospital49933, AngersMaine et Loire, France
Sponsors and collaborators
University Hospital, Angers
Lead sponsor
Source ClinicalTrials.gov