[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100483723":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":29,"locations":39,"responsibleParty":63,"collaborators":11,"id":65,"slug":11,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":66,"sex":72,"minAge":73,"maxAge":11,"enrollmentInfo":74,"targetDuration":11,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":42,"whyStopped":11,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"University Hospital, Angers","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Strategy A: PEEP 15 cmH2O → PEEP 5 cmH2O","EXPERIMENTAL",null,[13],"Procedure: PEEP decrease",{"label":15,"type":16,"description":11,"interventionNames":17},"Strategy B: PEEP 5 cmH2O → PEEP 15 cmH2O","ACTIVE_COMPARATOR",[18],"Procedure: PEEP increase",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"PROCEDURE","PEEP increase","Positive End Expiratory Pressure (PEEP) will be increased from 5 to 15 cmH2O.",[15],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"PEEP decrease","Positive End Expiratory Pressure (PEEP) will be decreased from 15 to 5 cmH2O.",[9],[30,35],{"name":31,"role":32,"phone":33,"phoneExt":11,"email":34},"François Beloncle, MD","CONTACT","+33 241 35 58 65","francois.Francois.Beloncle@chu-angers.fr",{"name":36,"role":32,"phone":37,"phoneExt":11,"email":38},"UH Angers DRCI","+33 2 41 35 54 96","DRCI-Promotion-Interne@chu-angers.fr",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Angers Hospital","RECRUITING","Angers","Maine et Loire","49933","France",{"type":48,"coordinates":49},"Point",[50,51],-0.55202,47.47156,{"lat":51,"lon":50},[54,57,60],{"name":31,"role":32,"phone":55,"phoneExt":11,"email":56},"+33 2 41 58 65","Francois.Beloncle@chu-angers.fr",{"name":58,"role":32,"phone":59,"phoneExt":11,"email":38},"UH Angers DRCI UH Angers","+33 5 41 35 54 96",{"name":61,"role":62,"phone":11,"phoneExt":11,"email":11},"francois beloncle, MD","PRINCIPAL_INVESTIGATOR",{"type":64,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100483723",false,"NCT05578742","V\u002FQ Matching Variations With PEEP in ARDS According to Compliance-based Phenotypes (France)","Effect of PEEP on Ventilartion\u002FPerfusion Ratios According to Different Phenotypes in Patients With ARDS (France)","MISMATCHED FR","Inclusion criteria:\n\n* intubated patients with moderate and severe ARDS (Berlin definition, PaO2\u002FFiO2 ≤200 mmHg at PEEP 5 cmH2O)\n* undergoing deep sedation\n* on controlled mechanical ventilation\n* between 24 hours and 5 days after intubation.\n\nExclusion criteria:\n\n* age \\\u003C18 years old; pregnancy\n* patient undergoing legal protection\n* contra-indications to EIT (e. g. severe chest trauma or wounds)\n* pneumothorax; patient undergoing ECMO\n* patient with BMI ≥35 kg\u002Fm2\n* hemodynamic instability with MAP \\\u003C60 mmHg despite vasopressors.","ALL","18 Years",{"count":75,"type":76},50,"ESTIMATED","INTERVENTIONAL",[79],"NA","This study aim to compare the effect of Positive End Expiratory Pressure (PEEP) on ventilation\u002Fperfusion mismatch in two phenotypes of patients with moderate-to-severe Acute Respiratory Distress Syndrome (ARDS), characterized by their respiratory system elastance (Ers). Ventilation\u002Fperfusion mismatch will be assessed by Electrical Impedance Tomography (EIT).",[82],"ARDS",[84,85,86,87],"pulmonary perfusion","ventilation-perfusion mismatch","compliance","recruitability","2025-12-02",{"date":90,"type":91},"2025-12-08","ACTUAL",{"date":93,"type":91},"2024-02-08",{"date":95,"type":76},"2026-09",{"name":5,"class":6},1]