[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100582653":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":43,"responsibleParty":58,"collaborators":25,"id":61,"slug":25,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":25,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":25,"enrollmentInfo":69,"targetDuration":25,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":45,"whyStopped":25,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Massachusetts General Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Positive Psychology (PP) Intervention","EXPERIMENTAL","Participants will complete an adapted, optimized, phone-based, 9-week positive psychology (PP) intervention.",[13],"Behavioral: Positive Psychology (PP) Intervention",{"label":15,"type":16,"description":17,"interventionNames":18},"Educational Intervention","ACTIVE_COMPARATOR","Participants will complete a 9-week, phone-based educational intervention that matches the PP intervention in terms of both time and attention.",[19],"Behavioral: Educational Intervention",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","This is an adapted, optimized, phone-based, 9-week positive psychology (PP) intervention. Participants will complete 9 weekly phone sessions (30 minutes each) with a study interventionist in which they will review PP exercises that they have independently completed in between phone sessions. The PP exercises will be completed in a treatment manual that describes the PP exercise and provides space to write about the exercise and its effects, and to answer associated questions. A total of 9 sessions will be completed over the course of the program.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"This is an educational intervention that will match the PP intervention in terms of both time and attention. Participants will complete 9 weekly phone sessions (30 minutes each) with a study interventionist in which they will review educational exercises that they have independently completed in between phone sessions. The exercises will be completed in a treatment manual that describes the exercise and provides space to write about the exercise and its effects, and to answer associated questions. A total of 9 sessions will be completed over the course of the program.",[15],[30],{"name":31,"affiliation":5,"role":32},"Elizabeth N Madva, MD","PRINCIPAL_INVESTIGATOR",[34,39],{"name":31,"role":35,"phone":36,"phoneExt":37,"email":38},"CONTACT","617-724-6300","111-134-2334","emadva@mgh.harvard.edu",{"name":40,"role":35,"phone":41,"phoneExt":25,"email":42},"Emmett McGranaghan, BS","617-643-4489","emcgranaghan@mgb.org",[44],{"facility":5,"status":45,"city":46,"state":47,"zip":48,"country":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"RECRUITING","Boston","Massachusetts","02114","United States",{"type":51,"coordinates":52},"Point",[53,54],-71.05977,42.35843,{"lat":54,"lon":53},[57],{"name":31,"role":35,"phone":36,"phoneExt":37,"email":38},{"type":32,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Elizabeth N. Madva, M.D.","Assistant Professor of Psychiatry","100582653",false,"NCT06866106","Well-being in IBS: Strengths and Happiness (WISH) 2.0","The WISH Intervention for IBS: Feasibility, Preliminary Effects, and Candidate Gut-Brain Mechanisms","Inclusion Criteria:\n\n* IBS Diagnosis: Adult patients with an IBS diagnosis meeting standardized Rome IV diagnostic criteria.\n* Language and communication: English fluency and access to a phone.\n\nExclusion Criteria:\n\n* Presence of inflammatory bowel disease or other structural\u002Fbiochemical primary gastrointestinal illness that better explains IBS-like symptoms: As reported by the patient, their physician, and\u002For documented in the medical record.\n* Severe psychiatric illness: Current manic episode, psychosis, or active substance use disorder diagnosed via the Mini International Neuropsychiatric Interview (MINI) or Diagnostic Interview for Anxiety, Mood, and OCD and Related Neuropsychiatric Disorders (DIAMOND).\n* Cognitive impairment: Assessed using a six-item cognitive screen developed for research.\n* Presence of atrial fibrillation or a cardiac pacemaker, or daily use of beta blocking medication: As reported by the patient and\u002For documented in the medical record.\n* Plans to start or participate in another new behavioral health intervention or psychotherapy during the study period.","ALL","18 Years",{"count":70,"type":71},50,"ESTIMATED","INTERVENTIONAL",[74],"NA","The purpose of this study is to examine the feasibility, acceptability, preliminary effects, and candidate gut-brain mechanisms of an optimized positive psychology (PP) intervention for patients with irritable bowel syndrome (IBS), entitled \"WISH,\" compared to an educational control intervention.",[77],"Irritable Bowel Syndrome",[79,80,81,82,83],"irritable bowel syndrome","brain-gut behavior therapy","behavioral health intervention","psychological intervention","psychotherapy","2026-06-18",{"date":86,"type":87},"2026-06-22","ACTUAL",{"date":89,"type":87},"2025-10-30",{"date":91,"type":71},"2028-08",{"name":5,"class":6},1]