Whole-Brain Dynamics in the Natural Menstrual Cycle vs. an Ovarian Stimulated Cycle: Impact of Hormonal Fluctuations on Healthy Women Undergoing Ovarian Stimulation

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
Age25-35
SponsorART Fertility Clinics LLC

About this trial

The investigators aim is to investigate the brain's dynamic complexity across three phases of an ovarian stimulation cycle (basal, pre-OPU, mid-luteal), to observe the impact of externally administered hormones, and compare it with the corresponding phases of a natural menstrual cycle (early follicular, pre-ovulatory, mid-luteal) in the same woman. Brain activity patterns will be examined using resting-state fMRI in a sample of young, healthy, naturally cycling women.

Eligibility criteria

Qualifiers

Age group: 25 - 35 years old

BMI: 20 - 30

Anti-Mullerian Hormone (AMH): 1.3 - 5.9 ng/ml

Regular Menstrual Cycle: 26-35 days

Disqualifiers

History of ovarian surgery

Pathology of the ovaries

Mental health disorders

Use of medication influencing brain function

Trial design

Treatments tested in this trial

  • Functional Magnetic resonance imaging will be done on day 2 or 3 of the menstrual cycle, trigger-shot and egg retrieval.

Treatment groups

15 Participants
are divided into 1 treatment group

Locations

2
ART Fertility Clinics LLC00000, Abu DhabiAbu Dhabi Emirate, United Arab Emirates
ART Fertility Clinics LLC60202, Abu DhabiAbu Dhabi Emirate, United Arab Emirates

Sponsors and collaborators

ART Fertility Clinics LLC

Lead sponsor

Khalifa University for Science and Technology

Collaborator

New York University Abu Dhabi

Collaborator