[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100255343":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":28,"locations":33,"responsibleParty":59,"collaborators":62,"id":69,"slug":10,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":72,"acronym":10,"eligibilityCriteria":73,"healthyVolunteers":70,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":10,"studyType":80,"phases":10,"briefSummary":81,"conditions":82,"keywords":85,"overallStatus":49,"whyStopped":10,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Columbia University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Cases of ROHHAD syndrome",null,"Children diagnosed with ROHHAD syndrome during the course of their clinical care by their physicians.\n\nThe investigators will perform transcriptome profiling in this group.",[13],"Diagnostic Test: Transcriptome profiling",{"label":15,"type":10,"description":16,"interventionNames":17},"Control cohort","Unaffected first degree family members. The investigators will perform transcriptome profiling in this group.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DIAGNOSTIC_TEST","Transcriptome profiling","The investigators will obtain blood to extract peripheral mononuclear cells. These cells will be used to generate patient specific hypothalamic cells that will be used for transcriptome profiling.",[9,15],[25],{"name":26,"affiliation":5,"role":27},"Vidhu Thaker, MD","PRINCIPAL_INVESTIGATOR",[29],{"name":26,"role":30,"phone":31,"phoneExt":10,"email":32},"CONTACT","2128515315","vvt2114@cumc.columbia.edu",[34,47],{"facility":35,"status":36,"city":37,"state":38,"zip":39,"country":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":10},"Boston Children's Hospital","COMPLETED","Boston","New York","02115","United States",{"type":42,"coordinates":43},"Point",[44,45],-78.73753,42.62895,{"lat":45,"lon":44},{"facility":48,"status":49,"city":38,"state":38,"zip":50,"country":40,"cosmosGeoPoint":51,"geoPoint":55,"contacts":56},"Columbia University Irving Medical Center","RECRUITING","10032",{"type":42,"coordinates":52},[53,54],-74.00597,40.71427,{"lat":54,"lon":53},[57],{"name":26,"role":30,"phone":58,"phoneExt":10,"email":32},"212-851-5315",{"type":27,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Vidhu V. Thaker","Assistant Professor",[63,66],{"name":64,"class":65},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","NIH",{"name":67,"class":68},"ROHHAD Association","UNKNOWN","100255343",false,"NCT02602769","Whole Transcriptome Profiling and Metabolic Phenotyping in Children With ROHHAD Syndrome","Inclusion Criteria:\n\n* Children with ROHHAD syndrome\n\nExclusion Criteria:\n\n* Children with known genetic causes of obesity","ALL","2 Years","20 Years",{"count":78,"type":79},12,"ESTIMATED","OBSERVATIONAL","Rapid onset Obesity, Hypoventilation, Hypothalamic dysfunction and Autonomic Dysregulation (ROHHAD) is a syndrome named in 2007. The hallmark of the syndrome is the rapid onset obesity and dysregulation of central ventilation. There is little information about the metabolic changes that lead to the rapid onset obesity in these children. The investigators would like to study the metabolic phenotype of these children to understand the disturbances in energy balance that lead to the rapid onset obesity.",[83,84],"Childhood Obesity","Morbid Obesity",[86,87,88,89],"Hypoventilation syndrome","Hypothalamic dysfunction","Autonomic dysregulation","Rapid onsey obesity","2025-10-20",{"date":92,"type":93},"2025-10-21","ACTUAL",{"date":95,"type":10},"2015-11",{"date":97,"type":79},"2026-12",{"name":5,"class":6},2]