[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acl-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acl-injury":603},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,29,0,25,[9,40,68,95,117,147,167,192,215,235,261,283,301,327,353,372,398,418,449,469,497,516,535,556,578],{"id":10,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100644524",false,"NCT07671235","Differences in Outcomes and Failure Rates Between Allografts and Autografts in Revision Anterior Cruciate Ligament Reconstruction","ACLREV_GRAFT","Inclusion Criteria:\n\nAge 18-50 years at the time of surgery Male and female patients Patients undergoing revision anterior cruciate ligament (ACL) reconstruction with possible associated procedures, with at least 2 years of follow-up Written informed consent to participate in the study\n\nExclusion criteria:\n\nPatients lost to follow-up Refusal to provide informed consent Advanced knee osteoarthritis (Outerbridge grade III-IV) at the time of surgery Severe obesity (BMI \\> 35) Lower limb conditions preventing full weight-bearing standing during evaluation Active infection, hematologic disease, or rheumatologic disease at the time of assessment","ALL","18 Years","50 Years",{"count":20,"type":21},150,"ESTIMATED","OBSERVATIONAL","Anterior cruciate ligament (ACL) rupture is one of the most common knee injuries, particularly in young and physically active individuals. Despite advances in reconstruction techniques, graft failure and rerupture remain clinically relevant. Revision ACL surgery is more complex than primary reconstruction and is associated with inferior outcomes, with rerupture rates of approximately 13%, reaching up to 25% when both subjective and objective failure criteria are considered.\n\nThe main goal of ACL reconstruction is to restore anteroposterior and rotational knee stability, prevent secondary meniscal and cartilage damage, and enable return to sport. Surgical outcomes depend on several intraoperative factors, including graft choice and tunnel geometry, which are particularly relevant in revision settings.\n\nDiagnosis of ACL rerupture is primarily clinical, based on instability tests (Lachman, anterior drawer, pivot shift), and supported by instrumental assessment such as the KT-1000 arthrometer, which provides an objective measure of joint laxity.\n\nRevision ACL reconstruction can be performed using different surgical techniques (single-bundle, double-bundle, or combined extra-articular procedures) and graft types (autograft or allograft). Surgical strategy depends on multiple factors such as meniscal and cartilage status, previous surgery characteristics, tunnel positioning\u002Fenlargement, and fixation devices. However, no consensus exists regarding the optimal approach in terms of mid- to long-term outcomes.\n\nA major long-term complication is the development of osteoarthritis, particularly in this typically young and active patient population. Identification of modifiable factors, such as surgical technique and graft type, may help reduce failure risk and joint degeneration.\n\nThis study aims to evaluate clinical and radiographic outcomes over a follow-up period exceeding two years in patients undergoing revision ACL reconstruction with different surgical techniques and graft types. The study also integrates objective knee laxity assessment using KT-1000 and markerless motion analysis based on artificial intelligence. Functional movements are recorded via video and analyzed using Sports2D software, enabling 2D kinematic analysis without markers or sensors, providing quantitative functional data to complement clinical and radiographic evaluation.",[25,26],"ACL Injury","Graft Failure","NOT_YET_RECRUITING","2026-06-22",{"date":30,"type":31},"2026-06-26","ACTUAL",{"date":33,"type":21},"2026-07",{"date":35,"type":21},"2027-05",{"name":37,"class":38},"Stefano Zaffagnini","OTHER",1,{"id":41,"slug":4,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":17,"enrollmentInfo":48,"targetDuration":4,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":39},"100641432","NCT07580625","Reducing Disparities in Knee Arthroscopy for Adolescents","RED KARD: Reducing Disparities in Knee Arthroscopy for Adolescents","RED KARD","Inclusion Criteria:\n\n* Predominantly Hispanic soccer team\n* Players between 14-18 years of age\n\nExclusion Criteria:\n\n-Players younger than 14 or older than 18 years of age","14 Years",{"count":49,"type":21},80,"INTERVENTIONAL",[52],"NA","Hundreds of thousands of youth athletes require surgery for knee injuries annually. The incidence of operative knee injuries has skyrocketed, but surgery can be delayed due to late recognition and barriers, such as insurance, language, and difficulty navigating the healthcare system. Delays may have lifelong effects, including arthritis, persistent instability, poor patient reported outcomes, and reoperation. There is little patient-centered research on barriers to orthopaedic care, and none on interventions to reduce disparities in pediatric sports medicine. This study will focus on Hispanic children, a growing population nationally and 38% of the Chicago's children, who are at increased risk of delayed knee surgery and its sequelae compared to white, non-Hispanic patients. The overall objectives are to identify barriers to timely knee surgery in Hispanic athletes and develop an intervention to implement evidence on expedient treatment. The aim of this study is to evaluate feasibility, acceptability, and appropriateness of a culturally-tailored intervention in a pilot study of Hispanic youth soccer leagues. The proposed study will drive creation of a future community trial of a culturally-tailored intervention.",[55,25,56,57,58],"Knee Injury","Meniscus Tear","Hispanic or Latino","Adolescent","2026-06-16",{"date":61,"type":31},"2026-06-18",{"date":63,"type":21},"2027-10-01",{"date":65,"type":21},"2029-07",{"name":67,"class":38},"Ann & Robert H Lurie Children's Hospital of Chicago",{"id":69,"slug":4,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":11,"sex":16,"minAge":74,"maxAge":18,"enrollmentInfo":75,"targetDuration":4,"studyType":50,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":39},"100406426","NCT04572256","MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MOCHA Trial)","MOCHA","Inclusion Criteria:\n\n1. Undergoing primary ACL reconstruction\n2. Age between 25-50\n3. Concomitant meniscus injury\n\nExclusion Criteria:\n\n1. Undergoing revision procedures\n2. Multiple ligament injuries requiring multiple ligament reconstruction\u002Frepair\n3. Depressive symptoms and\u002For those who endorse suicidal ideation at the time of enrollment (PHQ-9 score \\>= 15)\n4. Found to not have a meniscus tear at the time of surgery","25 Years",{"count":76,"type":21},30,[78],"EARLY_PHASE1","This is a multicenter randomized, placebo-controlled trial to assess whether a 6-month course of oral montelukast after ACL reconstruction reduces systemic markers of inflammation and biochemical and imaging biomarkers of cartilage degradation. This study will specifically target older ACL reconstruction patients with concomitant meniscal injuries as this group is at greatest risk of rapid PTOA progression. Patients will randomly be assigned to receive oral montelukast (10 mg) versus placebo daily for 6 months after surgery.",[25,56,81],"Post-traumatic Osteoarthritis",[83,84],"knee ligament","osteoarthritis","RECRUITING","2026-06-08",{"date":88,"type":31},"2026-06-10",{"date":90,"type":31},"2021-02-01",{"date":92,"type":21},"2027-06",{"name":94,"class":38},"Austin V Stone",{"id":96,"slug":4,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":100,"eligibilityCriteria":101,"healthyVolunteers":102,"sex":16,"minAge":4,"maxAge":17,"enrollmentInfo":103,"targetDuration":4,"studyType":50,"phases":105,"briefSummary":106,"conditions":107,"keywords":4,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":39},"100425869","NCT04825587","The Pediatric ALL Evaluation and Trial","The Pediatric ALL Evaluation and Trial: A Randomized, Controlled Trial","PALLET","Inclusion Criteria:\n\n* Age 18 and under\n* Surgery within 6 months of injury\n* Undergoing primary ACL reconstruction without previous injury or surgery\n* Quadriceps tendon autograft ACL reconstruction\n* Closing or closed physes\n\nExclusion Criteria:\n\n* Over 18 years old\n* Previous ipsilateral knee injury or surgery\n* Neuromuscular or developmental disorders affecting knee anatomy, cognition, or neuromuscular control\n* Other concomitant ligament reconstruction aside from the ALL (i.e., MCL, PCL, PLC)\n* Revision ACL reconstruction\n* ACL reconstruction with graft other than quadriceps tendon\n* IT band (modified MacIntosh) ACL reconstruction\n* A cartilage lesion requiring anything more than debridement\n* Open physes requiring both femoral and tibial physeal-sparing technique",true,{"count":104,"type":21},240,[52],"The overall aim of this multicenter RCT is to determine whether concomitant ALL reconstruction in children undergoing and ACL reconstruction will longitudinally result in a lower rate of graft failure than ACL reconstruction alone.",[25,108],"ACL Tear","2026-05-27",{"date":111,"type":31},"2026-05-29",{"date":113,"type":31},"2021-04-28",{"date":115,"type":21},"2030-04-01",{"name":67,"class":38},{"id":118,"slug":4,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":122,"eligibilityCriteria":123,"healthyVolunteers":102,"sex":16,"minAge":17,"maxAge":124,"enrollmentInfo":125,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":127,"conditions":128,"keywords":131,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":39},"100534200","NCT06235736","Do Patients With ACL Tears Demonstrate Weakness of the Soleus Muscle?","Do Patients With Anterior Cruciate Ligament (ACL) Tears Demonstrate Weakness of the Soleus Muscle?","ACL","Inclusion Criteria:\n\nACL tear participants:\n\n* MRI-confirmed ACL tear.\n* Participant is willing and able to give informed consent in writing for participation in the study.\n* Male or Female, aged 18 years to 55 years of age.\n* No contraindications to strength testing (see exclusion criteria).\n\nNormative values from healthy individuals:\n\n* No current or previous history of significant lower limb injury, or a history of previous minor injury that is symptomatic at the time of recruitment.\n* No previous lower limb surgery.\n* No course of medication, whether prescribed or over the counter, other than vitamins and mineral supplements or, for females, oral contraceptives.\n\nExclusion Criteria:\n\n* History of chronic musculoskeletal disease or disorder in either leg that may put the participants at risk because of participation in the study including non-united fractures, epilepsy, cardiac insufficiency, severe peripheral vascular disease, aneurysms, anticoagulant therapy, recent (\\<3 months) radiotherapy or chemotherapy, long term steroid use (\\>3 months), pregnancy, neurological disorders (e.g., Parkinson's disease), skin conditions at point of force testing, severe osteoporosis, malignancy, rheumatoid arthritis.\n\n  * Conditions or symptoms that may influence the result of the study, or the participant's ability to participate in the study including pain, limited range of motion, knee effusion, or anaemia.","55 Years",{"count":126,"type":21},55,"The goal of this prospective, cross-sectional study is to test the strength of the soleus muscle in participants who have a ACL tear confirmed by MRI. Previous studies have shown that the soleus muscle, which one of the muscles situated in the calf, decreases mechanical loading on the ACL. Therefore, we aim to test soleus muscle strength using a seated plantar flexor test.\n\nThe main questions we aim to answer are:\n\n* Do patients with ACL tears demonstrate inter-limb soleus strength asymmetry (\\>10%)\n* Do patients with ACL tears have soleus muscle weakness compared with uninjured (normative) participants?\n* Do changes in soleus strength values correlate with patient reported outcomes and stability, as measured by the IKDC questionnaire?\n\nTo achieve this the VALD force frame will be used as the testing device for plantar flexor strength testing. This device records the force generated by the movement. This will be repeated three times on each leg as part of the testing procedure. Furthermore, as part of the testing procedure participants will be required to fill out an IKDC form to assess their knee stability. Interrater reliability of the force frame will be investigated.\n\nFurther data from participants without ACL tears will be used to compare results. Thus allowing us to see if people with ACL tears have a weakness in the soleus muscle.",[108,129,130],"ACL-injury","ACL - Anterior Cruciate Ligament Rupture",[132,122,133,134,135,136,137],"Acute cruciate ligament","soleus muscle","physiotherapy","orthopaedics","trauma","rehabilitation","2026-04-30",{"date":140,"type":31},"2026-05-06",{"date":142,"type":31},"2024-01-17",{"date":144,"type":21},"2027-12-31",{"name":146,"class":38},"University of Liverpool",{"id":148,"slug":4,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":150,"acronym":4,"eligibilityCriteria":151,"healthyVolunteers":11,"sex":16,"minAge":152,"maxAge":18,"enrollmentInfo":153,"targetDuration":4,"studyType":50,"phases":155,"briefSummary":156,"conditions":157,"keywords":158,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":165,"locationsCount":4},"100460048","NCT05270551","The Effect of Accelerated Rehabilitation After Anterior Cruciate Ligament Reconstruction With and Without Suture Tape Reinforcement","Inclusion Criteria:\n\n* Age from 15 to 50 years old.\n* With or without meniscal injury.\n* Isolated ACL injury without any other ligament injury.\n* Recent and chronic injury.\n\nExclusion Criteria:\n\n* Multiligament injury.\n* Deformed knee (Genu varus or valgus).\n* Previous ACL reconstruction or repair.\n* Older than 50 years old and younger than 15 years old.\n* Failed ACL reconstruction or repair -","15 Years",{"count":154,"type":21},114,[52],"The aim of our study is to evaluate the effect of accelerated rehabilitation post ACL reconstruction with and without augmentation on graft healing and return to normal activity clinically by scoring system and radiologically.",[25],[159],"Rehabilitation","2026-04-28",{"date":138,"type":31},{"date":163,"type":21},"2026-05-01",{"date":35,"type":21},{"name":166,"class":38},"Assiut University",{"id":168,"slug":4,"hasResults":11,"nctId":169,"briefTitle":170,"officialTitle":170,"acronym":4,"eligibilityCriteria":171,"healthyVolunteers":102,"sex":16,"minAge":172,"maxAge":173,"enrollmentInfo":174,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":176,"conditions":177,"keywords":180,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":39},"100564937","NCT06635668","Baseline ACL Injury Risk Screening and Normative Data","Inclusion Criteria:\n\n* Healthy athletes participating in formal, organized, competitive sports between the ages of 10 and 65 years old","10 Years","65 Years",{"count":175,"type":21},5000,"This is a prospective, observational cohort study aimed at establishing a database of normative biomechanics for healthy athletes and surveying these athletes for 12 months following baseline testing for the occurrence of new musculoskeletal injuries, with a particular emphasis on ACL injuries.",[25,178,179],"Anterior Cruciate Ligament Injuries","Musculoskeletal Injury",[181,182],"Athletes","Biomechanics","2026-04-14",{"date":185,"type":31},"2026-04-17",{"date":187,"type":31},"2022-07-19",{"date":189,"type":21},"2033-07-01",{"name":191,"class":38},"Sanford Health",{"id":193,"slug":4,"hasResults":11,"nctId":194,"briefTitle":195,"officialTitle":195,"acronym":196,"eligibilityCriteria":197,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":198,"enrollmentInfo":199,"targetDuration":4,"studyType":50,"phases":201,"briefSummary":202,"conditions":203,"keywords":4,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":214,"locationsCount":39},"100600406","NCT07097077","Study of Functional Magnetic Resonance Signal Variations in Patients Undergoing Anterior Cruciate Ligament Reconstruction With the Application of a Dedicated Neuromotor Training","ACL-fMRI-TNMT","Inclusion Criteria:\n\n* Patients who have undergone anterior cruciate ligament reconstruction surgery at any healthcare facility\n* Able to understand and consent, adults, who have provided informed consent to participate in the study\n* Male or female\n* Age between 18 and 30 years at the time of signing the informed consent\n* Tegner activity level \\> 6\n\nExclusion Criteria:\n\n* History and\u002For evidence of any neurological disorder or functional impairment;\n* Evidence of previous surgeries on the lower limb;\n* Inability to provide informed consent;\n* Inability to perform the tasks required by the procedure;\n* Pregnant or breastfeeding women;\n* Oncology patients;\n* Contraindications to undergoing MRI examinations.","30 Years",{"count":200,"type":21},12,[52],"Lower limb injuries represent the majority of sports-related injuries, with knee injuries being among the most common. In particular, anterior cruciate ligament (ACL) injuries are considered highly devastating and career-threatening for both professional and amateur athletes. Current surgical and rehabilitation treatments often fail to provide fully satisfactory short- and long-term outcomes. A very high risk of re-injury exists, especially in younger patients, with up to 35% experiencing a second ACL injury, alongside a significant long-term risk of early knee osteoarthritis.\n\nMost ACL injuries are non-contact or indirect contact injuries, implicating biomechanical factors and neuromuscular control as key determinants of injury mechanisms. Recent literature shows that patients suffering a non-contact ACL injury have a higher risk of re-injury compared to those with contact injuries, suggesting a significant cognitive component in injury processing, surgery, rehabilitation, and return to sport.\n\nRecent rehabilitation studies have introduced targeted neuromotor training designed to \"rebuild\" biomechanical and neuromuscular patterns to avoid mechanisms leading to re-injury. Movement quality tests are used post-training to confirm the reduction of risky biomechanical patterns, often resulting in a score indicating movement quality.\n\nGiven the brain's involvement in such injuries, pioneering studies have used functional magnetic resonance imaging (fMRI) to investigate changes in cortical brain areas following ACL injury and reconstruction. Evidence shows adaptations in both central and peripheral nervous systems, with altered sensorimotor cortex activation in patients during simple motor tasks, differing from healthy subjects. Prefrontal cortex alterations correlate with severe quadriceps muscle activation asymmetries, linking these brain patterns to post-injury return-to-sport outcomes.\n\nHowever, no studies have yet evaluated the interaction between cortical activation (neural compensations) measured by fMRI and outcomes from targeted neuromotor training during ACL rehabilitation. Understanding brain activation implications is crucial for developing large-scale rehabilitation protocols to reduce the risk of a second, potentially more devastating, knee injury.\n\nThis study aims to reveal whether a neuromotor training protocol can positively influence cognitive brain areas related to human movement, particularly by reducing risky injury patterns. It will be the first to test whether dedicated neuromuscular training effectively reduces neural compensations and cortical activation related to non-automated movement, favoring automation areas important for a safe return to sport.\n\nPatients will directly benefit from participating in the innovative neuromotor training program, with functional MRI scans conducted before training begins (post-surgery) and after training completion. Indirectly, the study will assess whether neuromotor training can adapt patient neuromotor patterns to reduce re-injury risk, ultimately benefiting future patients undergoing ACL reconstruction.",[204,25,205,206],"fMRI","Rehabilitation Exercise","Neuromuscular Control","2026-02-25",{"date":209,"type":31},"2026-02-27",{"date":211,"type":31},"2026-02-07",{"date":213,"type":21},"2027-07",{"name":37,"class":38},{"id":216,"slug":4,"hasResults":11,"nctId":217,"briefTitle":218,"officialTitle":219,"acronym":220,"eligibilityCriteria":221,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":222,"enrollmentInfo":223,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":225,"conditions":226,"keywords":4,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":227,"lastUpdatePostDateStruct":228,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":234,"locationsCount":39},"100319659","NCT03441659","ACL Reconstruction: Clinical Outcome","Anterior Cruciate Ligament Reconstruction: Clinical Outcome at Middle and Long Term Follow-Up","RIC-ACL","Inclusion Criteria:\n\n1. Patients who have provided informed written written consent;\n2. Patients aged between 18 and 60;\n3. Patients undergoing reconstructive surgical treatment of the anterior cruciate ligament (ACL)\n\nExclusion Criteria:\n\n1. Patients unable to understand and to want;\n2. Patients who have not signed informed consent;","60 Years",{"count":224,"type":21},1000,"The study is intended to include all patients who will undergo surgical reconstruction of the anterior cruciate ligament (ACL). The patients will be monitored and evaluated preoperatively and also at 6 months and 1, 2 and 5 years after the intervention through a clinical visit or telephone interview. Such assessments will include the administration of questionnaires to determine the patient's functional symptoms and the objective examination of the knee during a medical examination to quantify its stability.",[25],"2026-01-29",{"date":229,"type":31},"2026-02-02",{"date":231,"type":31},"2020-12-17",{"date":233,"type":21},"2030-12",{"name":37,"class":38},{"id":236,"slug":4,"hasResults":11,"nctId":237,"briefTitle":238,"officialTitle":239,"acronym":240,"eligibilityCriteria":241,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":242,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":244,"conditions":245,"keywords":249,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":255,"completionDateStruct":257,"leadSponsor":259,"locationsCount":39},"100622652","NCT07386405","Validation and Cultural Adaptation of the KOOS-ACL Scale for the Italian Population","Italian Version of KOOS-ACL (Knee Injury and Osteoarthritis Outcomes Score - Anterior Cruciate Ligament): Translation, Cross-cultural Adaptation and Validation","VACKP","Inclusion Criteria:\n\n* Patient age 18 years or older\n* Patients who are native Italian speakers\n* Patients undergoing anterior cruciate ligament reconstruction of the knee\n* Patients who have understood and signed the informed consent to participate in the study.\n* Patients who are able to understand the study conditions and participate for the entire duration\n\nExclusion Criteria:\n\n* Patients unable to understand the text in Italian\n* Patients undergoing knee replacement surgery, corrective osteotomies, or osteosynthesis of knee fractures.\n* Patients who are drug addicts, alcoholics, suffer from psychiatric disorders, or have any clinical conditions that could compromise the success of the questionnaire.\n* Patients with orthopedic conditions of other origins",{"count":243,"type":21},120,"Submission of the KOOS ACL questionnaires in Italian for the purpose of validation and cultural adaptation of the KOOS-ACL scale for the Italian population.",[246,25,247,248],"Scale Reliability Validity","Validation and Cultural Adaptation of a Scale","PROMs",[250,122,251,248],"scale reliability","KOOS-ACL","2026-01-27",{"date":254,"type":31},"2026-02-04",{"date":256,"type":21},"2026-01-19",{"date":258,"type":21},"2027-07-01",{"name":260,"class":38},"I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio",{"id":262,"slug":4,"hasResults":11,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":4,"eligibilityCriteria":266,"healthyVolunteers":102,"sex":16,"minAge":47,"maxAge":198,"enrollmentInfo":267,"targetDuration":4,"studyType":50,"phases":269,"briefSummary":270,"conditions":271,"keywords":4,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":278,"leadSponsor":280,"locationsCount":282},"100476754","NCT05488054","Muscle O2 Saturation and Hemoglobin Levels During Rehabilitation From Arthroscopic Surgery","Use of a Wearable Muscle Oxygen Saturation Sensor in the Rehabilitation of High-School and Collegiate Athletes Recovering From Arthroscopic Hip and Knee Surgery","Inclusion Criteria:\n\n* Age range: Patients age 14 to 30 years\n* Patients with ACL injury requiring surgical correction\n* Patients undergoing arthroscopic hip surgery\n* Healthy individuals with no history of ACL, arthroscopic knee or arthroscopic hip surgery\n\nExclusion Criteria:\n\n* Patients below 14 years or above 30 years\n* Non-English-speaking subjects\n* Pregnant individuals",{"count":268,"type":21},226,[52],"This study will utilize the Moxy wearable sensor to measure muscle oxygen saturation levels in athletes following lower extremity surgery (ACL or Hip arthroscopy) to evaluate their Return-to-Play. The acquired data will complement current protocols utilized by Dr. Voos and Dr. Salata in this regard and will add quantifiable evidence to enable a robust measurement of the surgical limb versus non-surgical limb.",[25,272],"Hip Injuries","2025-12-22",{"date":275,"type":31},"2025-12-24",{"date":277,"type":31},"2022-08-08",{"date":279,"type":21},"2026-12",{"name":281,"class":38},"University Hospitals Cleveland Medical Center",2,{"id":284,"slug":4,"hasResults":11,"nctId":285,"briefTitle":286,"officialTitle":286,"acronym":287,"eligibilityCriteria":288,"healthyVolunteers":11,"sex":16,"minAge":152,"maxAge":18,"enrollmentInfo":289,"targetDuration":4,"studyType":50,"phases":290,"briefSummary":291,"conditions":292,"keywords":4,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":294,"lastUpdatePostDateStruct":295,"startDateStruct":296,"completionDateStruct":298,"leadSponsor":300,"locationsCount":39},"100469351","NCT05391672","Augmentation of Partial Anterior Cruciate Ligament Tear: Early Results","Augmentation","Inclusion Criteria:\n\n* age from 15 to 50 years old\n* Partial ACL tear without any other ligament injury\n* with and without meniscal tear\n* with and without knee deformity\n* recent and chronic injury\n\nExclusion Criteria:\n\n* younger than 15 and older than 50 y\n* multiligament injury\n* complete ACL tear\n* failed ACL reconstruction or repair",{"count":76,"type":21},[52],"Clinical evaluation for the patients with partial ACL tear who had ACL augmentation",[25,293],"ACL Augmentation","2025-12-17",{"date":273,"type":31},{"date":297,"type":31},"2022-06-09",{"date":299,"type":21},"2026-03-19",{"name":166,"class":38},{"id":302,"slug":4,"hasResults":11,"nctId":303,"briefTitle":304,"officialTitle":305,"acronym":4,"eligibilityCriteria":306,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":307,"targetDuration":4,"studyType":50,"phases":309,"briefSummary":311,"conditions":312,"keywords":315,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":318,"lastUpdatePostDateStruct":319,"startDateStruct":321,"completionDateStruct":323,"leadSponsor":325,"locationsCount":39},"100603374","NCT07135687","Study to Use Oral Losartan to Decrease the Risk of Postoperative Scarring Following (ACL) Reconstruction","Oral Losartan to Decrease the Risk of Postoperative Arthrofibrosis Following Primary and Revision Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n* Must be undergoing a primary ACLR with or without the following:\n* Chondroplasty\n* Synovectomy\n* Loose body removal\n* Removal of hardware\n* Meniscal surgery (excluding meniscal allograft transplantation\u002FMAT)\n* Lateral extra-articular tenodesis\n* Must have skeletal maturity in the distal femur and proximal tibial physes\n* Must be age 18 years or older at time of enrollment\n\nExclusion Criteria:\n\n* \\\u003C18 years at time of enrollment\n* No diagnosis of ACL tear\n* ACL repairs\n* Revision ACL reconstructions\n* Open distal femur or proximal tibia physes\n* Major concomitant procedures (such as osteotomy, MAT, or cartilage restoration surgery)\n* History of prior proximal or distal femur fracture (including those receiving nonoperative treatment)\n* History of prior ipsilateral femur or tibia osteomyelitis\n* Medical history\n* History of hypotensive disease, including postural orthostatic hypotension syndrome (POTS), autonomic dysreflexia, or Shy-Drager syndrome (aka multiple system atrophy), baseline hypotension \\\u003C90 systolic or \\\u003C60 diastolic mmHg.\n* History of significant hepatic disease (liver transplantation, cirrhosis of any cause, or any liver disease with Child-Pugh classification B or C) due to hepatic metabolism of ARBs.\n* Chronic kidney disease\n* Rheumatologic disorders on immunologic medications\n* Current medications including diuretics (i.e. furosemide), lithium, and spironolactone\n* Current hypertension with prescription of an ARB or ACE-I\n* Allergy to losartan\n* Current pregnancy or breastfeeding",{"count":308,"type":21},144,[310],"PHASE4","The purpose of this study to investigate the effect of using losartan (a blood pressure lowering drug with anti-scarring properties) on preventing primary postoperative arthrofibrosis (formation of abnormal scar tissue) in the knees in participants undergoing anterior cruciate ligament (ACL) repair surgery of their knee.",[25,313,314],"ACL Reconstruction","Scar Formation",[122,316,317],"Postoperative Arthrofibrosis","Losartan","2025-12-09",{"date":320,"type":31},"2025-12-15",{"date":322,"type":21},"2026-08",{"date":324,"type":21},"2028-12",{"name":326,"class":38},"Rush University Medical Center",{"id":328,"slug":4,"hasResults":11,"nctId":329,"briefTitle":330,"officialTitle":331,"acronym":4,"eligibilityCriteria":332,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":124,"enrollmentInfo":333,"targetDuration":4,"studyType":50,"phases":335,"briefSummary":336,"conditions":337,"keywords":340,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":345,"lastUpdatePostDateStruct":346,"startDateStruct":348,"completionDateStruct":350,"leadSponsor":351,"locationsCount":282},"100540028","NCT06311513","Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction","Multi-Center Pilot Study to Evaluate Concentrated Bone Marrow Aspirate (cBMA) as a Treatment to Modify Post-Traumatic Osteoarthritis (PTOA) Following Revision Anterior Cruciate Ligament Reconstruction (ACLR)","Inclusion Criteria:\n\n* Males and Females\n* Age 18 to 55\n* Previous unilateral ACLR (Anterior Cruciate Ligament Reconstruction) within the last 5 years, and identified as having experienced failure of the primary ACLR\n* Scheduled to have a revision ACLR surgery, with any graft type (including patellar tendon, hamstring, quad or allograft)\n* Able to complete all study procedures and participate in a standardized physical therapy program\n\nExclusion Criteria:\n\n* History of inflammatory arthritis or joint sepsis\n* Prior or concurrent total or sub-total meniscectomy\n* Prior or present avascular necrosis of the index knee\n* Oral or intra-articular corticosteroid injection within 3 months\n* Hyaluronic acid or PRP (Platelet-Rich Plasma) injection within 6 months\n* Use of duloxetine, doxycycline, indomethacin, glucosamine and\u002For chondroitin (ongoing or within 2 months)\n* Any clinical or laboratory abnormality greater than grade 3 CTCAE, which in the view of the investigator, will compromise the participant's safety.\n* Planned arthroplasty in the index knee",{"count":334,"type":21},40,[310],"The goal of this pilot randomized clinical trial is to look into the efficacy of concentrated bone marrow aspirate (cBMA) in improving post traumatic osteoarthritis (PTOA) symptoms in patients undergoing revision anterior cruciate ligament reconstruction surgery. The main questions it aims to answer are whether clinical outcomes, such as pain, are improved in patients who get cBMA with surgery, if there is a change in circulating markers of inflammation and what part of the cellular and molecular composition of cBMA may explain its effects.",[178,338,339,25],"Post-Traumatic Osteoarthritis of Knee","Bone Marrow Aspirate Concentrate",[341,342,343,344],"Regenerative Medicine","Orthobiologics","Concentrated Bone Marrow Aspirate","Revision ACLR","2025-11-19",{"date":347,"type":31},"2025-11-20",{"date":349,"type":31},"2024-01-22",{"date":324,"type":21},{"name":352,"class":38},"Hospital for Special Surgery, New York",{"id":354,"slug":4,"hasResults":11,"nctId":355,"briefTitle":356,"officialTitle":356,"acronym":4,"eligibilityCriteria":357,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":358,"targetDuration":360,"studyType":22,"phases":4,"briefSummary":361,"conditions":362,"keywords":4,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":363,"lastUpdatePostDateStruct":364,"startDateStruct":366,"completionDateStruct":368,"leadSponsor":370,"locationsCount":39},"100393887","NCT04408885","Rehabilitation Treatment of Anterior Cruciate Ligament Rupture","Inclusion Criteria:\n\n* Anterior cruciate ligament injury where rehabilitation regime is selected as treatment.\n\nExclusion Criteria:\n\n* Other knee ligament instability\n* Rheumatoid arthritis\n* Morbus Bechterews Disease",{"count":359,"type":21},400,"5 Years","The purpose with this present study is to investigate the effect og a non-surgical regime in patients with an Anterior Cruciate ligament injury.\n\nThe effect will be measured by patient reported outcome scores, level of function and how many of the patients are converting to operative treatment.",[25],"2025-09-30",{"date":365,"type":31},"2025-10-01",{"date":367,"type":31},"2020-08-15",{"date":369,"type":21},"2030-12-31",{"name":371,"class":38},"Aarhus University Hospital",{"id":373,"slug":4,"hasResults":11,"nctId":374,"briefTitle":375,"officialTitle":376,"acronym":377,"eligibilityCriteria":378,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":379,"enrollmentInfo":380,"targetDuration":4,"studyType":50,"phases":382,"briefSummary":383,"conditions":384,"keywords":386,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":390,"lastUpdatePostDateStruct":391,"startDateStruct":393,"completionDateStruct":395,"leadSponsor":396,"locationsCount":39},"100556790","NCT06529692","Michigan Split-belt Treadmill Training Program to Improve Long-Term Knee Biomechanics After ACL Reconstruction","Mi-SPA: Michigan Split-belt Adaptation Paradigm to Improve Knee Loading After Anterior Cruciate Ligament Reconstruction (Aim 3)","Mi-SPA","Inclusion Criteria:\n\n* aged 14-45 years\n* suffered an acute, complete ACL rupture as confirmed by MRI and physical exam\n* have undergone ACL reconstruction w autograft within the past 10 months\n* willingness to participate in testing and follow-up as outlined in the protocol\n* English-speaking\n\nExclusion Criteria:\n\n* inability to provide written informed consent\n* female subjects who are pregnant or are planning to become pregnant (self-reported)\n* previous ACL injury\n* previous surgery to either knee\n* bony fracture accompanying ACL injury\n* patients who experienced a knee dislocation\n* patients who had their ACL reconstructed with an allograft\n* patients who underwent a multi-ligamentous and\u002For staged ACL reconstruction","45 Years",{"count":381,"type":21},9,[52],"The goal of this study is to gather pilot data to help inform a future clinical trial. As such, the investigators will employ a randomized clinical trial design, but data will only be collected on 9 total subjects. Nine subjects will be randomized to 2 split-belt intervention groups (one group where early stance loading is trained and the other where midstance loading is trained) and a placebo group.\n\nThe goal of this study is to explore the adaptations in knee loading from a 6-week split-belt training intervention.\n\nThe investigators' main question for this aim is:\n\n1. Does knee loading, measured by the sagittal plane knee moment, change to a greater extent in the split-belt treadmill training groups compared to the placebo group?\n2. Are there differences in training-related knee loading changes between individuals trained in the early stance vs. midstance loading split-belt training?",[122,385,25],"Anterior Cruciate Ligament",[182,387,388,389],"Knee Loading","Split-Belt Treadmill","Asymmetric Walking","2025-09-04",{"date":392,"type":31},"2025-09-08",{"date":394,"type":31},"2025-08-13",{"date":322,"type":21},{"name":397,"class":38},"University of Michigan",{"id":399,"slug":4,"hasResults":11,"nctId":400,"briefTitle":401,"officialTitle":402,"acronym":403,"eligibilityCriteria":404,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":405,"targetDuration":4,"studyType":50,"phases":406,"briefSummary":407,"conditions":408,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":409,"lastUpdatePostDateStruct":410,"startDateStruct":412,"completionDateStruct":414,"leadSponsor":416,"locationsCount":4},"100604993","NCT07156734","Effect of Contralateral NMES on Quadriceps Activation After ACL Injury or Surgery","Does NMES Applied to the Contralateral Uninjured Side Facilitate Voluntary Quadriceps Activation Before and After ACL Surgery?","ACLQuadAct","Inclusion Criteria:\n\n* Patients undergoing ACL surgery with semitendinosus tendon autograft in the Schulthess Clinic\n* Unilateral and primary ACL injury (with\u002Fwithout diagnoses of additional meniscus injury)\n\nExclusion Criteria:\n\n* Previous surgery\u002Fligament rupture in injured or uninjured knee or hip\n* Severe pain in the uninjured-side quadriceps or knee joint\n* Ongoing pregnancy\n* BMI \\>30 kg\u002Fm²\n* Neuromuscular disease\n* Open wounds or tissue injuries on the anterior aspect of the thigh\n* Additional rupture of other knee ligaments (posterior cruciate ligament, medial collateral ligament, lateral collateral ligament)\n* Implanted metallic\u002Felectronic devices (cardiac pacemakers, defibrillators)\n* Patients getting a femoralis block (peripheral nerve block) after surgery will be excluded for the post-surgical appointment\n* Insufficient language comprehension",{"count":7,"type":21},[52],"A major complication after cruciate ligament injury and surgery is arthrogenic muscle inhibition of the quadriceps, which is characterised by a deficit in voluntary muscle activation in the affected leg. This can hinder rehabilitation processes, lead to impaired knee function, and negatively impact the patients' quality of life. The primary objective of this study is to assess whether voluntary quadriceps activation on the injured side is facilitated by the concomitant application of neuromuscular electrical stimulation (NMES) on the contralateral quadriceps.",[25],"2025-08-27",{"date":411,"type":31},"2025-09-05",{"date":413,"type":21},"2025-09",{"date":415,"type":21},"2026-09",{"name":417,"class":38},"Schulthess Klinik",{"id":419,"slug":4,"hasResults":11,"nctId":420,"briefTitle":421,"officialTitle":422,"acronym":122,"eligibilityCriteria":423,"healthyVolunteers":102,"sex":16,"minAge":17,"maxAge":379,"enrollmentInfo":424,"targetDuration":4,"studyType":50,"phases":426,"briefSummary":427,"conditions":428,"keywords":433,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":440,"lastUpdatePostDateStruct":441,"startDateStruct":443,"completionDateStruct":445,"leadSponsor":447,"locationsCount":39},"100603596","NCT07138573","Kinesio Taping for the Knee and Ankle: Acute Impact on Balance, Proprioception, and ACL Risk","Evaluation and Comparison of the Acute Effects of Kinesio Taping Applied to the Knee and Ankle in the Lower Extremity on Balance, Proprioception, and Anterior Cruciate Ligament Injury Risk Using the Landing Error Scoring System (LESS)","Inclusion Criteria:\n\n* Volunteering to participate in the study\n* Being 18 years of age or older\n* Being a licensed and regular volleyball player for at least 5 years\n\nExclusion Criteria:\n\n* Being enrolled in another study or treatment program\n* Being unable to complete the study for any other reason\n* Having suffered a lower extremity injury within 6 months prior to participating in the study\n* Female participants must be in their menstrual cycle",{"count":425,"type":21},24,[52],"This study aims to evaluate and compare the acute effects of Kinesio taping applied to the knee and ankle on balance, proprioception, and anterior cruciate ligament (ACL) injury risk using the Landing Error Scoring System (LESS). Designed as a randomized crossover trial, the study will include 24 healthy volleyball athletes with at least 5 years of experience. All participants will receive both ankle and knee taping interventions, separated by a one-week washout period. Assessments will be conducted at four time points: before and after each taping. Outcome measures include the Y-Balance Test, proprioception tests, and LESS.",[25,429,430,431,432],"Kinesiotape","Balance","Proprioception","Landing Error Scoring System (LESS)",[434,435,436,437,438,432,439],"ankle","knee","acl injury","balance","proprioception","kinesiotape","2025-08-21",{"date":442,"type":31},"2025-08-24",{"date":444,"type":21},"2025-08-30",{"date":446,"type":21},"2025-12-30",{"name":448,"class":38},"Tokat Gaziosmanpasa University",{"id":450,"slug":4,"hasResults":11,"nctId":451,"briefTitle":452,"officialTitle":453,"acronym":4,"eligibilityCriteria":454,"healthyVolunteers":102,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":455,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":457,"conditions":458,"keywords":459,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":461,"lastUpdatePostDateStruct":462,"startDateStruct":464,"completionDateStruct":466,"leadSponsor":468,"locationsCount":4},"100570441","NCT06707285","MRI Morphology of Femoral Notch in ACL Injury","MRI Imaging Assessment of Femoral Notch Morphology in Patients With ACL Injury","Inclusion Criteria:\n\n* patient aged 18-50 years.\n* diagnosed with an ACL injury and confirmed by MRI and age-matched controls.\n\nExclusion Criteria:\n\n* age \\\u003C18 yo and \\>50 years\n* patients with previous knee surgeries\n* congenital knee deformities\n* systemic conditions affecting bone health",{"count":456,"type":21},72,"This study aims to investigate the association between femoral notch morphology, as assessed by MRI, and the risk of ACL injury",[25],[460],"ACL ,femoral notch","2024-11-24",{"date":463,"type":31},"2024-11-27",{"date":465,"type":21},"2025-01-01",{"date":467,"type":21},"2027-01-01",{"name":166,"class":38},{"id":470,"slug":4,"hasResults":11,"nctId":471,"briefTitle":472,"officialTitle":473,"acronym":4,"eligibilityCriteria":474,"healthyVolunteers":102,"sex":475,"minAge":17,"maxAge":173,"enrollmentInfo":476,"targetDuration":478,"studyType":22,"phases":4,"briefSummary":479,"conditions":480,"keywords":484,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":488,"lastUpdatePostDateStruct":489,"startDateStruct":491,"completionDateStruct":493,"leadSponsor":495,"locationsCount":4},"100563837","NCT06621355","HemoNIRS: a Paradigm Shift in the Process of Musculoskeletal Rehabilitation of ACL Injuries in Cyclic Sports Athletes.","HemoNIRS: Un Cambio De Paradigma En El Proceso De Rehabilitación Musculoesquelética De Lesiones De Ligamento Cruzado Anterior Mediante Dispositivos NIRS En Deportistas Que Realizan Deportes Cíclicos","General inclusion criteria\n\n* Men aged 18 to 65\n* An adipose layer of \\<2 cm in areas of NIRS placement, assessed with a plicometer\n* Understand written, read and spoken Spanish, English or Catalan.\n\nGeneral exclusion criteria\n\n* Having any cardio-metabolic, hormonal, neurological or other comorbidities that could affect participation in the study (e.g. severe mental illness, end-stage disease).\n\nEligibility criteria (LCA1 group)\n\n* Regular athlete with training and\u002For competition \\>3 days\u002Fwk prior to injury.\n* ACL injury \\<6 months after surgery.\n* Able to perform an incremental intervallic test on a cycloergometer or treadmill.\n\nEligibility criteria (LCA2 group)\n\n* Regular athlete with training and\u002For competition \\>3 days a week.\n* ACL injury \\>2 years after surgery.\n* Able to perform an incremental intervallic test on a cycloergometer or treadmill.\n\nEligibility criteria (CON group)\n\n* Regular athlete with training and\u002For competition \\>3 days a week.\n* Never suffered an ACL injury in any knee - Able to perform incremental intervallic test on cycleergometer or treadmill.\n\nAll the groups exclusion criteria\n\n\\- Incapacitating pain that prevents assessment","MALE",{"count":477,"type":21},129,"1 Day","Muscle haemodynamics has so far been assessed using at most 2-3 near-infrared spectroscopy devices on isolated muscles and without correlating variables. At the same time, research on musculoskeletal pathologies is limited, and there are no studies that analyse the haemodynamic changes that occur when the anterior cruciate ligament (ACL) is injured and whether these changes last over time. The aim of the study is to monitor and evaluate the physiological changes produced by ACL injury on muscle performance using non-invasive near-infrared spectroscopy (NIRS) devices in trained athletes. This descriptive cross-sectional observational multicentre multicentre study, with Balearic Islands ethics committee IB 5585\u002F24PI, will include males aged 18-65 years who have undergone ACL surgery, divided into 3 groups that: have an evolution of less than 6 months (ACL1), more than 2 years since the surgical intervention and are already practising normal physical-sports activities (ACL2) and the control group (CON) that has never suffered an ACL affectation to date. The 3 groups will perform an incremental intervallic test (4:1) on a cycloergometer or treadmill (according to the specificity of their sport), where different muscular haemodynamic variables will be assessed using 12-24 NIRS devices. The main study variables will be the muscular haemodynamic values of each muscle analysed and their correlation between them: muscular oxygen saturation, absolute capillary haemoglobin, loaded and unloaded with oxygen and relative muscular haemoglobin blood flow, loaded and unloaded with oxygen. Secondary variables will be heart rate, socio-demographic variables (age, toxic habits, injury and sports history) and subjective perception of effort (RPE-20).",[130,25,481,482,483],"Hemodynamics","Oxygen Consumption Based Assessment of Hemodynamics","Exercise",[485,481,483,486,487],"Spectroscopy, Near-Infrared","Vascular resistance","Oxygen consumption","2024-09-27",{"date":490,"type":31},"2024-10-01",{"date":492,"type":21},"2024-12-02",{"date":494,"type":21},"2026-12-02",{"name":496,"class":38},"Universitat de Lleida",{"id":498,"slug":4,"hasResults":11,"nctId":499,"briefTitle":500,"officialTitle":501,"acronym":4,"eligibilityCriteria":502,"healthyVolunteers":11,"sex":16,"minAge":503,"maxAge":4,"enrollmentInfo":504,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":505,"conditions":506,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":507,"lastUpdatePostDateStruct":508,"startDateStruct":510,"completionDateStruct":512,"leadSponsor":514,"locationsCount":39},"100561029","NCT06584838","Primary ACL Reconstruction in Patient Over 40 Years: Allograft Versus Autograft","Primary ACL Reconstruction in Patient Over 40 Years: Allograft Versus Autograft, a Prospective Matched Paired Comparison","Inclusion Criteria:\n\n* Participant is willing and able to give informed consent for participation in the study.\n* Male and female patients of fertile age can be recruited\n* Patients aged 40 years old and above, and 2 years minimum of follow-up\n* Patients that underwent primary ACL reconstruction with allograft an autograft tendons\n\nExclusion Criteria:\n\n* Multiligamentous lesion\n* Meniscal tear leading to subtotal or total meniscectomy or meniscal graft\n* Indication for major cartilage restoration or resurfacing\n* Ipsilateral knee fractures\n* History of ligament injury\n* Concomitant extracapsular procedures\n* Ipsilateral or contralateral knee surgeries","40 Years",{"count":334,"type":21},"The aim of this study is to investigate the differences in graft failure between patients that underwent ACL reconstruction using allograft tendons and patients that underwent ACL reconstruction using autograft tendons in patients older than 40 y.o. and after at least 2 years of follow-up. The hypothesis of the study is that there will be a difference in graft failure and patient reported functional outcomes between allograft and autograft ACL reconstruction.",[122,25],"2024-09-02",{"date":509,"type":31},"2024-09-05",{"date":511,"type":21},"2024-12",{"date":513,"type":21},"2025-02",{"name":515,"class":38},"Università Vita-Salute San Raffaele",{"id":517,"slug":4,"hasResults":11,"nctId":518,"briefTitle":519,"officialTitle":520,"acronym":521,"eligibilityCriteria":522,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":503,"enrollmentInfo":523,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":524,"conditions":525,"keywords":4,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":526,"lastUpdatePostDateStruct":527,"startDateStruct":529,"completionDateStruct":531,"leadSponsor":533,"locationsCount":39},"100556420","NCT06524869","Association Between Neuromuscular Parameters and Functional Assessment After ACL Reconstruction","Association of Strength and Proprioception Parameters With Qualitative Assessment of Functional Tasks After ACL Reconstruction","KASTLAB","Inclusion Criteria:\n\n* Adult patients, aged 18-40, who have undergone a first ACL reconstruction more than 6 months ago and are being followed in a sports medicine care pathway\n* Affiliated with a health insurance plan\n* Information form: Non-objection to the use of data for research purposes\n\nExclusion Criteria:\n\n* Previous ligament surgery of the lower limbs prior to ACL reconstruction\n* Complex ligament injury (lateral ligaments, posterior cruciate ligament)\n* Recent muscle injuries\n* History of injury to the uninjured knee\n* Pregnant woman\n* Neurological history with residual effects or taking medication that affects balance\u002Fcoordination\n* Inability to perform a muscular assessment\n* Postoperative complications (deep vein thrombosis, sepsis, stiffness\u002Farthrofibrosis)",{"count":7,"type":21},"The anterior cruciate ligament (ACL) injury is common in athletes aged 18 to 35. ACL reconstruction (ACLR) aims to restore knee stability in the process of returning to sports. Post-surgical rehabilitation focuses on optimizing biomechanical parameters, with neuromuscular and functional tests assessing muscle strength, proprioception, and dynamic stability. Isokinetic allows the measurement of muscle strength symmetry and proprioception, while the single-leg hop and landing tasks assess functional stability and are predictive of sports resumption and injury prevention. Despite progress, concerns remain about neuromuscular factors impacting knee stability, especially during landings, which can increase the risk of secondary ACL injuries.\n\nThis study proposes examining knee strength and proprioception using isokinetic dynamometry, alongside biomechanical assessments from functional tests, to explore their relationship to biomechanical features during landings, at 6-to-12 months post-ACL reconstruction. The hypothesis is that better muscle strength and proprioception correlate with improved knee control during landing tasks.",[25],"2024-07-24",{"date":528,"type":31},"2024-07-29",{"date":530,"type":31},"2024-03-10",{"date":532,"type":21},"2024-08-30",{"name":534,"class":38},"University Hospital, Caen",{"id":536,"slug":4,"hasResults":11,"nctId":537,"briefTitle":538,"officialTitle":538,"acronym":539,"eligibilityCriteria":540,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":503,"enrollmentInfo":541,"targetDuration":4,"studyType":50,"phases":542,"briefSummary":543,"conditions":544,"keywords":4,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":547,"lastUpdatePostDateStruct":548,"startDateStruct":550,"completionDateStruct":552,"leadSponsor":554,"locationsCount":39},"100531930","NCT06206200","The Effects of Cognitive Dual-Tasking in Later Stages of Rehabilitation After ACL Reconstruction","AMIRA","Inclusion Criteria:\n\n* 18-40 years old.\n* Having suffered an ACL rupture.\n* Undergoing a surgical ACL reconstruction in the AZ Delta hospital in Roeselare (Campus Brugsesteenweg).\n\nExclusion Criteria:\n\n* Revision ACL reconstruction.\n* Other severe injuries to the lower limbs within the past year.\n* Muscle or neurological disorders affecting lower limb functioning.\n* Fibromyalgia or chronic fatigue syndrome.",{"count":49,"type":21},[52],"Anterior cruciate ligament (ACL) injuries are common in sports and often require a long and challenging rehabilitation process. Athletes who sustain these injuries typically engage in pivoting and cutting sports, where these motor tasks must be performed simultaneously with cognitive tasks such as decision-making and keeping an eye on the opponent. Directing attention to both cognitive and motor tasks leads to cognitive-motor interference, which is associated with movement patterns that increase the risk of ACL (re)injury.\n\nTherefore, it is crucial that before returning to such demanding sports after ACL reconstruction, athletes sufficiently develop and automate safe yet efficient motor skills to free up attentional capacity for decision-making, thereby reducing the risk of suboptimal movement patterns and reinjury.\n\nHowever, current rehabilitation programs often primarily focus on the motor component in a single-task manner, giving insufficient attention to the cognitive component that is inseparable from sports.\n\nThis randomized controlled trial aims to investigate the effects of implementing motor-cognitive dual tasks in the end phase rehabilitation after ACL reconstruction on muscle function, functional outcomes, and patient-reported outcomes.",[545,546,25],"Anterior Cruciate Ligament Reconstruction","Athrogenic Muscle Responses","2024-07-12",{"date":549,"type":31},"2024-07-15",{"date":551,"type":31},"2023-10-15",{"date":553,"type":21},"2027-04-01",{"name":555,"class":38},"University Ghent",{"id":557,"slug":4,"hasResults":11,"nctId":558,"briefTitle":559,"officialTitle":560,"acronym":4,"eligibilityCriteria":561,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":503,"enrollmentInfo":562,"targetDuration":564,"studyType":22,"phases":4,"briefSummary":565,"conditions":566,"keywords":4,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":571,"lastUpdatePostDateStruct":572,"startDateStruct":574,"completionDateStruct":575,"leadSponsor":577,"locationsCount":39},"100549189","NCT06430775","Exploring Prolonged AMR in ACL Reconstructed Patients","Exploring Prolonged Arthrogenic Muscle Responses and Associated Factors After Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n* 18-40 years old.\n* Having suffered an ACL rupture.\n* Undergoing a surgical ACL reconstruction in the AZ Delta hospital in Roeselare (Campus Brugsesteenweg).\n\nExclusion Criteria:\n\n* Revision ACL reconstruction.\n* Other severe injuries to the lower limbs within the past year.\n* Muscular or neurological disorders affecting lower limb functioning.\n* Fibromyalgia or chronic fatigue syndrome.",{"count":563,"type":21},190,"5 Months","The goal of this observational study is to explore the significance of subject-reported outcomes and clinical parameters in relation to the occurence of prolonged presence of arthrogenic muscle responses (AMR) in anterior cruciate ligament (ACL) reconstructed patients. The main questions it aims to answer are:\n\n1\\. Is there a link between the long-term occurence of AMR in ACL reconstructed patients and the level of kinesiophobia experienced before or after their ACL surgery? We hypothesize that ACL patients with higher levels of kinesiophobia are more likely to exhibit prolonged AMR as an unconscious reaction to protect their affected knee joint.\n\n2\\. Is the long-term presence of AMR in ACL reconstructed patients linked to their subjective knee function and stability (at certain time points throughout their recovery)? Our hypothesis is that poorer subjective knee function and stability might be associated with the presence of prolonged arthrogenic muscle responses in ACL reconstructed patients.\n\n3\\. Is the prolonged presence of AMR in ACL reconstructed patients linked to their pain levels (at certain time points throughout their recovery)? Our hypothesis is that ACL patients with higher pre- and\u002For postsurgical pain levels may exhibit a higher degree of long-lasting AMR.\n\n4\\. Is the long-term presence of AMR in ACL reconstructed patients linked to clinical parameters such as swelling, isometric quadriceps and hamstrings strength and knee range of motion (at certain time points throughout their recovery)? Our hypothesis is that ACL patients with poorer outcomes in terms of these clinical parameters may be more likely to exhibit prolonged AMR.\n\nParticipants will:\n\n* Fill in the following questionnaires 1 week before surgery and at 1 and 3 months after surgery:\n\n  * Demopgraphical information\n  * Knee Injury and Osteoarthritis Outcome Score (KOOS)\n  * Lysholm Score (only question 1)\n  * Tegner Activity Scale (current activity level, pre-injury activity level and desired activity level after recovery)\n  * Numeric Rating Score (NRS) for pain levels during the day \\& during the night\n  * ACL-Return to Sport after Injury Scale (ACL-RSI)\n* Complete a testing protocol 5 months after their surgery, which includes bilateral electromyographical measurements of the hamstrings and quadriceps during jumping tasks and a quadriceps inhibition measurement using the interpolated twitch method to evaluate the presence of prolonged AMR.",[178,567,568,122,25,108,545,569,570],"Anterior Cruciate Ligament Rupture","Anterior Cruciate Ligament Tear","Arthrogenic Muscle Inhibition","Arthrogenic Muscle Responses","2024-06-28",{"date":573,"type":31},"2024-07-01",{"date":551,"type":31},{"date":576,"type":21},"2026-05",{"name":555,"class":38},{"id":579,"slug":4,"hasResults":11,"nctId":580,"briefTitle":581,"officialTitle":582,"acronym":583,"eligibilityCriteria":584,"healthyVolunteers":11,"sex":16,"minAge":585,"maxAge":4,"enrollmentInfo":586,"targetDuration":4,"studyType":50,"phases":588,"briefSummary":589,"conditions":590,"keywords":591,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":595,"lastUpdatePostDateStruct":596,"startDateStruct":597,"completionDateStruct":599,"leadSponsor":601,"locationsCount":39},"100496657","NCT05747079","Immediate Versus Optional Delayed Surgical Repair for Treatment of Acute ACL Injuries","Comparison of Immediate Versus Optional Delayed Surgical Repair for Treatment of Acute Anterior Cruciate Ligament Injury Through a Parallel, Multicentric, Pragmatic Randomized Controlled Trial","IODA","Inclusion Criteria:\n\n* Rotational trauma to a knee that had no previous serious injury and for which medical advice was sought within 4 weeks after the injury.\n* Medical diagnosis of ACL insufficiency including MRI (both partial and complete ruptures)\n* Minimum of 16 years\n\nExclusion Criteria:\n\n* Participant has a history of a previous ACL injury or knee surgery to the index knee\n* Indication for acute surgery because of related injuries to the knee\n* Female who is pregnant or plans to become pregnant in the first 4 months of the trial. Since MRI assessment cannot be performed.","16 Years",{"count":587,"type":21},280,[52],"Currently, most patients with an anterior cruciate ligament injury undergo surgery. There is a general belief that surgical reconstruction is necessary to safely return to sports and to prevent early knee osteoarthritis or additional meniscus injuries. But there is insufficient scientific evidence to support this belief. Moreover, several studies show that surgical reconstruction of the cruciate ligament does not guarantee successful return to sports or the prevention of osteoarthritis and secondary meniscus injuries. Therefore, immediate surgery after an anterior cruciate ligament injury is questioned. So far, only two RCTs (KANON study and COMPARE study) have assessed this, and they could not show that immediate reconstruction is an added value (in terms of symptoms, knee function, activity level, osteoarthritis or additional meniscal injuries) compared to a conservative approach consisting of rehabilitation and late surgery for persistent knee instability.\n\nTherefore, this additional multicenter RCT, aims to 1) verify these results and 2) to identify predictors that predict which patients in the conservative group will not require late surgery. This has not been investigated to date. It is suspected that factors such as symptoms, strength, findings on the MRI scan and psychological factors may play a role in whether or not a patient will be able to successfully rehabilitate without surgical repair.\n\nThis information is invaluable to physicians because it allows them to decide which treatment is best for the patient.",[25],[122,592,593,594],"RCT","Conservative treatment","ACL reconstruction","2024-06-27",{"date":571,"type":31},{"date":598,"type":31},"2023-03-02",{"date":600,"type":21},"2028-03-02",{"name":602,"class":38},"Universitaire Ziekenhuizen KU Leuven",""]