[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"adhesive-capsulitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:adhesive-capsulitis":621},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,29,0,25,[9,44,76,109,131,152,173,197,219,249,280,304,325,346,370,394,416,444,471,493,515,538,562,583,604],{"id":10,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100638452",false,"NCT07628335","Effects of Gong's Mobilization With and Without Nielasher Technique on in Adhesive Capsulitis","Effects of Gong's Mobilization With and Without Niel Asher Technique on Shoulder Pain, Range of Motion and Disability in Adhesive Capsulitis","Inclusion Criteria:\n\n* Individuals with age group of 40-60 years.\n* Both Females and males individuals.\n* Individuals diagnosed with Frozen shoulder (Adhesive Capsulitis) within stage II and III of frozen shoulder.\n* Individuals with positive capsular pattern (ER\\>Abd\\> IR).\n* Individuals with ROM loss ≥ 25% in at least two planes compared with the noninvolved shoulder\n\nExclusion Criteria:\n\n* Individuals with rotator cuff tears and overuse injury\n* Individuals with inflammatory diseases (Osteoarthritis, Rheumatoid Arthritis, Gout) and Malignancies\n* Individuals Using Corticosteroid Injections or Medications",true,"ALL","40 Years","60 Years",{"count":21,"type":22},46,"ESTIMATED","INTERVENTIONAL",[25],"NA","Adhesive Capsulitis causes a progressive tightening of the glenohumeral joint capsule, restricting both active and passive movements and resulting in functional impairments. Joint mobilization is an essential component of physical therapy for managing adhesive capsulitis. Two new techniques are emerging in the treatment of Adhesive capsulitis; one of them is called Gong's Mobilization. This technique emphasizes correcting positional faults by applying controlled, dynamic movements to the glenohumeral joint. The other technique, known as Niel-Asher technique is a five-step trigger point therapy which offers a unique, non-invasive holistic approach to address adhesive capsulitis. This study, will be conducted as a randomized clinical trial at Ghurki Trust Teaching Hospital and Hope Rehabilitation Center, it aims to evaluate the effects of Gong's mobilization with and without Niel-Asher technique on shoulder pain, ROM and disability in Adhesive Capsulitis of patients aged 40-60 years. A non-probability convenience sampling method will recruit 46 participants meeting the inclusion criteria only. Participants will be randomly assigned to Group A (Gong's Mobilization) or Group B (Gong's mobilization and and Niel-Asher technique) with interventions given for four weeks. Pain severity will be measured using the Numeric Pain Rating Scale, Range of Motion will be assessed via goniometer, and disability will be evaluated using the SPADI. Statistical analysis using SPSS will compare outcomes between groups at baseline, at two weeks and post-treatment after 4 weeks.",[28],"Adhesive Capsulitis",[28,30],"goniometer","RECRUITING","2026-06-04",{"date":34,"type":35},"2026-06-05","ACTUAL",{"date":37,"type":35},"2025-12-15",{"date":39,"type":22},"2026-07-15",{"name":41,"class":42},"Riphah International University","OTHER",1,{"id":45,"slug":4,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":43},"100533757","NCT06229964","Frozen Shoulder Treatment With Intra-Articular Corticosteroid Injection and Suprascapular Nerve Block","A Double Blinded Randomized Controlled Trial (RCT) Exploring the Additional Effect of a Suprascapular Nerve Block in Combination With an Intra-Articular Corticosteroid Injection in Patients With Frozen Shoulder","FROSTBLOCK","Inclusion Criteria:\n\n* Written informed consent to participate in the study must be obtained from the subject prior to initiation of any study-mandated procedure\n* Suffering from Frozen Shoulder, defined as: Frozen shoulder is a self-limiting disease characterized by pain and functional restriction in both active and passive shoulder motion lasting more than 1 month, for which radiographic findings of the shoulder joint are unremarkable.\n* Dutch or French speaking persons\n* Age ≥ 18 years\n\nExclusion Criteria:\n\n* Subjects with posttraumatic or postsurgical stiff shoulder syndrome\n* History of trauma at the onset of symptoms\n* Subjects with rheumatologic or neurologic disease involving the shoulder\n* Subjects with cervical radiculopathy\n* Coagulation disorder\n* Hypersensitivity to local anesthetics or MRI contrast agent\n* Inability to understand the study procedures\n* Psychiatric illness\n* Pregnancy\n* Subjects who have received prior SSNB in the homolateral shoulder\n* Subjects who have received an IACI in the homolateral shoulder in the 3 months before inclusion• Systematic yeast infections\n* Hypovolaemia\n* Infections at the injection site\n* Medical history of malignant hyperthermia, major conduction disorders, acute cardiac decompensation, shock conditions, convulsions\n\nControl subjects for the diagnostic accuracy part of the study protocol\n\n* Inclusion criteria:\n* Written informed consent to participate in the study must be obtained from the sub-ject prior to initiation of any study-mandated procedure\n* Subjects suffering from shoulder pain that do not fulfill the diagnostic criteria of Frozen Shoulder\n* Dutch or French speaking persons\n* Age ≥ 18 years\n* Contralateral shoulder of Frozen Shoulder subjects\n* Exclusion criteria\n* Subjects with posttraumatic or postsurgical stiff shoulder syndrome\n* History of trauma at the onset of symptoms\n* Subjects with rheumatologic or neurologic disease involving the shoulder\n* Subjects with cervical radiculopathy\n* Coagulation disorder or treatments with anticoagulants\n* Hypersensitivity to MRI contrast agent\n* Inability to understand the study procedures\n* Psychiatric illness\n* Pregnancy\n* Systematic yeast infections\n* Hypovolaemia\n* Infections at the injection site\n* Medical history of malignant hyperthermia, major conductin disorders, acute cardi-ac decompensation, shock conditions, convulsions","18 Years","99 Years",{"count":54,"type":22},110,[25],"Frozen shoulder remains a challenging disease to treat as pain and loss of range of motion can persist for many months or even years. This loss of function can have a severe impact on the patient's activities, participation and overall quality of life.\n\nThe use of ultrasound-guided (USG) suprascapular nerve blocks (SSNB) and\u002For intra-articular corticoid injections (IACI) has been supported by many studies. However, double blinded randomized clinical trials using a combination of SSNB and IACI are rare.\n\nThe primary objective of this study is to compare the effectiveness of a glenohumeral IACI combined with a SSNB, compared to a glenohumeral IACI combined with a sham SSNB. Outcome measures of interest are shoulder-related disability reported by the patients, shoulder pain and shoulder stiffness. These outcome parameters will be compared between both treatment arms with an intention-to-treat analysis.\n\nAs key secondary objectives, the investigators aim to identify which physical examination tests, or combinations of those, are correlated with MRI diagnostic criteria and favor a more positive evolution. Finally, through predictive analysis the investigators will try to establish which patients benefit the most from the combined SSNB + IACI.",[58,28],"Frozen Shoulder",[58,60,61,62,63,64,65,66],"Adhesive Capsulitis of the Shoulder","Intra-articular corticosteroid injection","ultra-sound guided injection","suprascapular nerve block","Joint Diseases","Musculoskeletal Diseases","Bursitis","2026-05-28",{"date":69,"type":35},"2026-06-01",{"date":71,"type":35},"2025-02-28",{"date":73,"type":22},"2028-05-31",{"name":75,"class":42},"Universitair Ziekenhuis Brussel",{"id":77,"slug":4,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":17,"minAge":51,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":23,"phases":85,"briefSummary":86,"conditions":87,"keywords":91,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":43},"100630864","NCT07493213","USG-Guided Shoulder Injections in Frozen Shoulder","Effectiveness of USG-Guided Shoulder Injections as an Adjunct to a Home Exercise Program in the Conservative Management of Painful Frozen Shoulder and Its Association With Pain Phenotypes","Inclusion Criteria:\n\nAge between 18 and 75 years and willingness to participate in the study\n\nPresence of shoulder pain lasting at least 3 months and a diagnosis of primary frozen shoulder\n\nPain intensity ≥ 4\u002F10 on the Visual Analog Scale (VAS), resistant to medical treatment\u002Fanalgesics\n\nRestriction of ≥30 degrees in at least two planes of shoulder motion (flexion, abduction, or external rotation)\n\n\\-\n\nExclusion Criteria:\n\n* History of shoulder trauma\n\nPresence of neurological conditions such as stroke, brachial plexus injury, Parkinson's disease, or cervical spine pathology with or without radiculopathy\n\nHistory of shoulder surgery, shoulder malignancy or tumor, or prior shoulder manipulation\n\nPresence of shoulder arthritis, rotator cuff tear, other shoulder injuries, or thoracic outlet syndrome\n\nSystemic diseases affecting the shoulder, severe degeneration or trauma (e.g., osteoarthritis, rheumatoid arthritis, labral or articular cartilage injuries), or inflammatory rheumatic diseases\n\nSteroid injection to the affected extremity within the last 3 months, use of oral steroids or NSAIDs, or ongoing surgical\u002Finterventional treatment\n\nPregnancy or lactation\n\nUncontrolled diabetes, heart failure, or uncontrolled systemic diseases (e.g., liver failure, chronic kidney disease, significant endocrine disorders)\n\nCommunication problems or severe psychiatric disorders","75 Years",{"count":84,"type":22},68,[25],"Frozen shoulder (adhesive capsulitis) is characterized by pain and a progressive restriction of both active and passive shoulder range of motion, significantly impairing daily activities and quality of life. This study aims to evaluate the effectiveness of USG-guided shoulder injections, when added to a home-based exercise program, in the conservative management of patients with chronic, painful frozen shoulder.\n\nIn this prospective randomized study, patients diagnosed with painful frozen shoulder will be included. In addition to a standardized home-based exercise program, patients will receive either USG-guided suprascapular nerve block alone or a combination of suprascapular nerve block and subacromial injection. The effects of these approaches on clinical outcomes will be assessed over a 20-week follow-up period.\n\nPrimary outcome measures include pain intensity assessed by the Visual Analog Scale (VAS), functional status evaluated by the Shoulder Pain and Disability Index (SPADI), and shoulder range of motion. Secondary outcomes include depression level (Beck Depression Inventory), sleep quality, pain phenotype (nociplastic, neuropathic, or nociceptive), hand grip strength, ultrasonographic findings ( (coracohumeral ligament thickness, subacromial bursa thickness) , and patient satisfaction (subjective impression of improvement).\n\nThe results of this study are expected to provide evidence on the comparative effectiveness and additional benefits of different shoulder injection approaches when combined with home-based exercise therapy in patients with chronic frozen shoulder.",[58,28,88,89,90],"Shoulder Pain","Nociplastic Pain","Neuropathic Pain",[58,28,92,93,88,94,95,96,97,98],"Shoulder Injection","Home Exercise Program","Range of Motion","SPADI","Ultrasound-Guided Injection","pain phenotypes","exercises","2026-05-11",{"date":101,"type":35},"2026-05-14",{"date":103,"type":35},"2026-04-01",{"date":105,"type":22},"2027-06-30",{"name":107,"class":108},"Konya Beyhekim Training and Research Hospital","OTHER_GOV",{"id":110,"slug":4,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":17,"minAge":51,"maxAge":82,"enrollmentInfo":115,"targetDuration":4,"studyType":23,"phases":117,"briefSummary":118,"conditions":119,"keywords":121,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":126,"startDateStruct":127,"completionDateStruct":128,"leadSponsor":130,"locationsCount":43},"100630865","NCT07493226","Efficacy of Chemically Distinct Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Pain Phenotypes in Adhesive Capsulitis","Comparative Efficacy of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) With Distinct Chemical Structures in Shoulder Adhesive Capsulitis and the Role of Pain Phenotypes","Inclusion Criteria:\n\n1. Being between 18-75 years of age\n2. Having shoulder pain that has lasted for at least one month and being diagnosed with primary frozen shoulder\n3. Having a VAS pain level ≥ 4\u002F10\n4. Having ≥30 degrees of range of motion restriction in at least two planes (flexion, abduction, or external rotation)\n5. Not having any exclusion criteria and agreeing to participate in the study voluntarily\n\nExclusion Criteria:\n\n1. Patients with a history of shoulder trauma, those with musculoskeletal disorders characterized by pain and loss of function in the affected extremity (such as lateral epicondylitis, flexor tendon injury, de Quervein's tenosynovitis)\n2. Presence of neurological involvement such as stroke, brachial plexus injury, Parkinson's disease, and cervical spine injury with or without radiculopathy\n3. History of shoulder surgery, malignancy or tumor in the shoulder, those who have undergone shoulder manipulation\n4. Presence of shoulder arthritis, rotator cuff tear or other shoulder injuries, thoracic outlet syndrome\n5. Systemic disease affecting the shoulder region, severe degeneration or trauma (e.g., osteoarthritis, rheumatoid arthritis, history of labrum or articular cartilage injuries), inflammatory rheumatic diseases\n6. Those who have received steroid injections into the affected extremity within the last 3 months, those using oral steroids or NSAIDs, those receiving any surgical or interventional treatment, or Planned individuals:\n7. Those who are pregnant or lactating\n8. Those with uncontrolled diabetes, heart failure, uncontrolled systemic disease (liver disease, chronic kidney failure, significant endocrine disorders, etc.)\n9. Those with communication problems, severe psychiatric disorders\n10. Those allergic to NSAIDs or with any contraindications\n11. Those with bleeding, coagulation disorders, stomach ulcers, or symptomatic gastritis",{"count":116,"type":22},120,[25],"Patients aged 18-75 years who present to a tertiary rehabilitation hospital with shoulder pain and restricted range of motion, and who consent to participate, will be included in the study. Eligibility will be determined based on predefined inclusion and exclusion criteria.\n\nEligible patients will be randomly assigned to receive one of several nonsteroidal anti-inflammatory drugs (NSAIDs) with differing chemical properties (e.g., diclofenac, meloxicam, or indomethacin), in combination with a home-based exercise program for shoulder adhesive capsulitis. Patients' sociodemographic data, as well as detailed clinical and examination findings and baseline outcomes, will be recorded. Patients will be informed about their condition, and modifications to activities of daily living will be recommended.Patients' pain phenotypes (nociceptive, neuropathic, nociplastic) will be categorized based on clinical history and questionnaires, and it will be determined which pain types derive greater benefit from NSAIDs.\n\nFollow-up assessments will be conducted at the end of the first and second weeks. At the first-week follow-up, pain intensity will be evaluated using the Visual Analog Scale (VAS). If the treatment is deemed effective (defined as a ≥3-point reduction or ≥50% decrease in VAS), the same NSAID will be continued for an additional week; otherwise, it will be switched to an alternative NSAID with a different biochemical profile (group). The outcomes assessments will be performed by a blinded evaluator to minimize bias.",[58,28,88,120,89,90],"NSAID (Non-Steroidal Anti-Inflammatory Drug)",[122,123,124,97,98,125],"frozen shoulder","adhesive capsulitis","shoulder pain","Nonsteroidal Anti-Inflammatory Drugs",{"date":101,"type":35},{"date":103,"type":35},{"date":129,"type":22},"2027-03-30",{"name":107,"class":108},{"id":132,"slug":4,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":11,"sex":17,"minAge":137,"maxAge":138,"enrollmentInfo":139,"targetDuration":4,"studyType":23,"phases":141,"briefSummary":142,"conditions":143,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":43},"100640462","NCT07588087","Effect of Adding Latissimus Dorsi Myofascial Release to Scapular Proprioceptive Neuromuscular Facilitation on Pain, Disability, and Range of Motion in Adhesive Capsulitis","Effect of Adding Latissimus Dorsi Myofascial Release to Scapular Proprioceptive Neuromuscular Facilitation on Pain, Disability, and Range of Motion in Adhesive Capsulitis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* 1\\. Age between 35 and 70 years.\n* Both male and female participants.\n* Stiffening (Stage II) phase of frozen shoulder.\n* Pain intensity ≥ 4\u002F10 on NPRS during shoulder movement.\n* Unilateral shoulder involvement.\n* Presence of capsular pattern:ER \\> ABD \\> IR limitation\n* Apley's Scratch Test\n* Limited both ROMs\n* Symptom duration between 3 and 9 months.(Di Mascio et al., 2024)\n\nExclusion Criteria:\n\n* Secondary adhesive capsulitis due to trauma or surgery\n* History of shoulder fracture or dislocation.\n* Bilateral frozen shoulder.\n* Active systemic inflammatory or neurological disease\n* Recent intra-articular corticosteroid injection (within last 3 months)\n* Current anticoagulation therapy or bleeding disorders.\n* Pregnant females.","35 Years","70 Years",{"count":140,"type":22},58,[25],"This randomized controlled trial aims to compare the effects of scapular proprioceptive neuromuscular facilitation (PNF) alone versus PNF combined with latissimus dorsi myofascial release on pain, range of motion, and functional disability in patients with stage II adhesive capsulitis; a condition characterized by capsular stiffness, pain, and restricted shoulder mobility, with outcomes assessed using NPRS, goniometry, and SPADI over a 6-week intervention period.",[28],"2026-05-08",{"date":101,"type":35},{"date":147,"type":35},"2026-04-05",{"date":149,"type":22},"2026-06-08",{"name":151,"class":42},"Ibadat International University, Islamabad",{"id":153,"slug":4,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":157,"eligibilityCriteria":158,"healthyVolunteers":11,"sex":17,"minAge":51,"maxAge":4,"enrollmentInfo":159,"targetDuration":4,"studyType":23,"phases":161,"briefSummary":162,"conditions":163,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":43},"100529628","NCT06176248","Evaluation of the Efficacy of Suprascapular Nerve Block in Adhesive Capsulitis","Evaluation of the Efficacy of Suprascapular Nerve Block in Adhesive Capsulitis: a Randomized Controlled Superiority Trial","BAC-Reims","Inclusion Criteria:\n\n* Patient treated for adhesive capsulitis corresponding to a loss of passive amplitude of more than 20° in external rotation elbow to body and\u002For abduction in relation to the contralateral shoulder.\n* Patient over 18 years of age\n* Patient covered by a social security scheme\n* Presence of an accompanying person on the day of the procedure for the return trip\n* Patient having signed the consent form to participate in the study\n\nExclusion Criteria:\n\n* Patient protected by law\n* Pregnant women\n* Patient who has had shoulder surgery less than six months old\n* Patient unable to undergo rehabilitation within one month of surgery\n* Allergy to one of the products used (anesthetic, iodinated contrast medium)\n* Neuro-orthopedic disorder hampering clinical recovery\n* Hemostasis disorder contraindicating block (no discontinuation of anticoagulants according to SFAR recommendations, congenital hemostasis disorder)",{"count":160,"type":22},62,[25],"This is a double-blind interventional superiority study evaluating the efficacy of suprascapular nerve block in addition to conventional therapies for adhesive capsulitis.\n\nAdhesive capsulitis is a pathology that results in reduced shoulder mobility due to retraction of the periarticular capsule. It may be primary or secondary to traumatic or neurological events, or associated with diabetes in particular.\n\nThe usual treatment includes re-education sessions to improve joint amplitude and restore shoulder mobility. In persistent forms, intra-articular injection of cortisone is combined with distension of the capsule with a local anaesthetic under radiographic control.\n\nIn some countries, subscapular nerve block (reversible anaesthesia) is used to improve pain. The combination of arthrodistension and subscapular nerve block has never been performed to accelerate the healing process.\n\nThe aim of this study is to compare the performance of these two procedures together against the reference technique alone on time to improvement with the number of patients improved at one month according to the Constant score.\n\nThis score is used to assess shoulder pain and function, with a significant improvement above eight points.",[28],"2026-05-05",{"date":166,"type":35},"2026-05-06",{"date":168,"type":35},"2024-10-11",{"date":170,"type":22},"2027-03",{"name":172,"class":42},"CHU de Reims",{"id":174,"slug":4,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":176,"acronym":4,"eligibilityCriteria":177,"healthyVolunteers":11,"sex":178,"minAge":18,"maxAge":19,"enrollmentInfo":179,"targetDuration":4,"studyType":23,"phases":181,"briefSummary":182,"conditions":183,"keywords":184,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":43},"100638645","NCT07576127","Effects of Gongs Mobilization and Proprioceptive Neuromuscular Facilitation in Patients With Adhesive Capsulitis","Inclusion Criteria:\n\n* Females in the age group between 40-60 years.\n* Diagnosed with Unilateral frozen shoulder.\n* Patients in frozen stage (progressive loss of ROM, marked stiffness with gradual pain reduction).\n* More than 25% painful limitation of GH ROM in two planes, more than 50% in external rotation(arm at 0 degree of abduction).\n\nExclusion Criteria:\n\n* History of surgery on the affected shoulder.\n* Patients having any cervical or thoracic problem.\n* Painful, stiff shoulder after severe trauma, inflammatory diseases such as rheumatoid arthritis and malignancies.\n* Recent fractures in and around the shoulder.\n* Rotator cuff disorder.","FEMALE",{"count":180,"type":22},44,[25],"The randomized controlled trail aims is to evaluate the outcome of Gongs mobilization and PNF in patients with adhesive capsulitis. The significance of this study is to compare Gong's mobilization technique with proprioceptive neuromuscular facilitation (PNF) compare their effects on pain, range of motion, and functional disability. The sample size was calculated with G-power. This study would include total 44 female participants aged 40-60 years will be recruited and randomly assigned to two groups. Group A(Gongs mobilization+ conventional therapy)and Group B(PNF+ Conventional therapy). Intervention will be provided for 4 weeks 3 session per week. Primary outcome measures are pain, ROM and functional disability via NPRS, Goniometer and U-SPADI. Outcomes will be reassessed at baseline, after 2nd week, and after 4th week.",[28],[185,186,187,188,189],"Pain","ROM","Functional Disability","Gongs Mobilization","PNF","2026-05-04",{"date":144,"type":35},{"date":193,"type":35},"2025-09-01",{"date":195,"type":22},"2026-05-15",{"name":41,"class":42},{"id":198,"slug":4,"hasResults":11,"nctId":199,"briefTitle":200,"officialTitle":201,"acronym":4,"eligibilityCriteria":202,"healthyVolunteers":11,"sex":17,"minAge":203,"maxAge":4,"enrollmentInfo":204,"targetDuration":4,"studyType":23,"phases":206,"briefSummary":207,"conditions":208,"keywords":209,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":214,"completionDateStruct":215,"leadSponsor":217,"locationsCount":43},"100630324","NCT07486193","Effects of Nunchaku Exercise for Improving Frozen Shoulder","Effects of Nunchaku Exercise on Adhesive Capsulitis (Frozen Shoulder) in Middle-aged and Older Adults: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Ethnic Chinese;\n* Age 45 years or above;\n* Diagnosed with Adhesive Capsulitis (Frozen Shoulder) and currently in the thawing stage.\n\nExclusion Criteria:\n\n* Presence of secondary causes of shoulder stiffness, including recent trauma, post-surgical stiffness, or structural lesions such as full-thickness rotator cuff tears or severe glenohumeral arthritis;\n* Receipt of recent shoulder treatments known to influence short-term outcomes, including corticosteroid injections within the past three months, hydrodilatation, manipulation under anesthesia, arthroscopic capsular release within the past six months, or structured shoulder physiotherapy within the past three months;\n* Presence of somatic conditions that limit their ability to participate safely in exercise (e.g., inability to walk without an assistive device).","45 Years",{"count":205,"type":22},50,[25],"The goal of this clinical trial is to investigate if nunchaku exercise works to treat adhesive capsulitis, or frozen shoulder in middle-aged or older adults. It will also learn about the adherence of this exercise intervention. The main questions it aims to answer are:\n\n* Does practicing nunchaku exercises help reduce shoulder pain and improve shoulder movement?\n* Do people stick with nunchaku exercises better, and spend more time practicing on their own, compared with standard exercises for alleviating frozen-shoulder?\n\nResearchers will compare nunchaku exercise to standard exercises for alleviating frozen-shoulder to see if nunchaku exercise works to alleviate frozen shoulder.\n\nParticipants will:\n\n* Join small group exercise classes for 12 weeks, doing either nunchaku based exercises or standard exercises designed to help relieve frozen shoulder.\n* Have their shoulder pain and movement checked three times:\n\n  * before training\n  * after 6 weeks of training,\n  * after finishing the 12 week program, and\n  * 12 weeks after the program ends.\n* Keep a record of their home practice time.",[28],[58,210,123],"Nunchaku exercise","2026-04-14",{"date":213,"type":35},"2026-04-17",{"date":211,"type":35},{"date":216,"type":22},"2026-12-31",{"name":218,"class":42},"Chinese University of Hong Kong",{"id":220,"slug":4,"hasResults":11,"nctId":221,"briefTitle":222,"officialTitle":223,"acronym":224,"eligibilityCriteria":225,"healthyVolunteers":11,"sex":17,"minAge":226,"maxAge":138,"enrollmentInfo":227,"targetDuration":229,"studyType":230,"phases":4,"briefSummary":231,"conditions":232,"keywords":233,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":240,"lastUpdatePostDateStruct":241,"startDateStruct":243,"completionDateStruct":245,"leadSponsor":247,"locationsCount":43},"100631025","NCT07495306","Electrophysiologic Changes After Extended 360° Capsular Release","Electrophysiological Evidence of Neural Function Improvement After Extended Arthroscopic Circumferential Capsular Release for Adhesive Capsulitis","FROZEN-EMG","Inclusion Criteria:\n\n* Age between 21 and 70 years\n* Diagnosis of adhesive capsulitis (frozen shoulder)\n* Persistent symptoms despite conservative treatment (e.g., physical therapy, medication, or intra-articular injections)\n* Planned arthroscopic capsular release surgery\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Known peripheral neuropathy\n* Previous brachial plexus injury\n* History of ipsilateral shoulder neurovascular surgery\n* Previous proximal brachial plexus surgery\n* Coagulation disorders\n* Active infection\n* Pregnancy","21 Years",{"count":228,"type":22},15,"12 Weeks","OBSERVATIONAL","Frozen shoulder (adhesive capsulitis) is a condition characterized by shoulder pain and restricted range of motion, significantly impairing daily living activities. In cases that do not respond to conservative treatment, arthroscopic capsular release is an effective surgical treatment option. The 360° capsular release technique, performed by some surgeons, involves release of the inferior capsule and therefore carries a potential risk of nerve injury due to the anatomical proximity of neurovascular structures such as the axillary nerve. In addition, surgical manipulations performed around the coracoid process may exert mechanical or compressive effects on the musculocutaneous nerve and its sensory continuation, the lateral antebrachial cutaneous nerve, due to their close relationship with the lateral cord of the brachial plexus.\n\nThe aim of this prospective, single-center observational clinical study is to objectively evaluate the morphological and functional effects of inferior capsular release and coracoid region dissection performed during arthroscopic 360° capsular release surgery on the axillary and musculocutaneous nerves, using electromyography (EMG) and nerve conduction studies (NCS) in patients with frozen shoulder.\n\nPatients aged 21-70 years with a diagnosis of frozen shoulder who have not responded to conservative treatments and are scheduled for arthroscopic capsular release will be included in the study. EMG and NCS assessments will be performed at the preoperative baseline, and at 12 weeks postoperatively. For the axillary nerve, the deltoid and teres minor muscles will be evaluated; for the musculocutaneous nerve, the biceps brachii and brachialis muscles will be assessed. Additionally, sensory conduction of the lateral antebrachial cutaneous nerve will be examined. Along with electrophysiological findings, shoulder range of motion (ROM), pain (VAS), muscle strength (MRC), and functional scores will also be recorded.\n\nThis study is expected to provide objective evidence regarding the effects of arthroscopic capsular release surgery on peripheral nerve function, thereby contributing new data on the safety of the surgical technique and enriching the currently limited literature on electromyographic evaluation in frozen shoulder surgery.",[28,58],[28,234,235,236,237,238,239],"360° Capsular Release","Shoulder Arthroscopy","Electromyography","Axillary Nerve","Musculocutaneous Nerve","Peripheral Nerve Function","2026-03-23",{"date":242,"type":35},"2026-03-27",{"date":244,"type":35},"2026-02-26",{"date":246,"type":22},"2027-03-14",{"name":248,"class":42},"Acibadem University",{"id":250,"slug":4,"hasResults":11,"nctId":251,"briefTitle":252,"officialTitle":253,"acronym":254,"eligibilityCriteria":255,"healthyVolunteers":11,"sex":17,"minAge":51,"maxAge":4,"enrollmentInfo":256,"targetDuration":4,"studyType":23,"phases":257,"briefSummary":258,"conditions":259,"keywords":263,"overallStatus":270,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":272,"startDateStruct":274,"completionDateStruct":276,"leadSponsor":278,"locationsCount":43},"100622166","NCT07380087","Suprascapular Nerve Block to Improve Tolerance and Outcomes of Shoulder Hydrodistension in Adhesive Capsulitis","Efficacy of Suprascapular Nerve Block on the Tolerability and Effectiveness of Shoulder Hydrodistension in Patients With Adhesive Capsulitis: A Randomized Clinical Trial","SHINE","Inclusion Criteria\n\n* Adults aged 18 years or older\n* Clinical diagnosis of adhesive capsulitis of the shoulder\n* Persistent pain and functional limitation despite initial conservative treatment\n* Ability to understand study procedures\n* Ability to provide written informed consent\n\nExclusion Criteria\n\n* Known allergy or hypersensitivity to ropivacaine or methylprednisolone\n* Active infection (local or systemic)\n* Uncontrolled coagulopathy or ongoing therapeutic anticoagulation\n* Recent surgery of the affected shoulder\n* Neurological disease affecting the upper limb\n* Pregnancy",{"count":205,"type":22},[25],"Adhesive capsulitis (\"frozen shoulder\") causes significant pain and loss of shoulder mobility. Shoulder hydrodistension is an established treatment that can improve movement and reduce symptoms, but the procedure itself may be painful and difficult for some patients to tolerate.\n\nThis randomized clinical trial will evaluate whether performing a suprascapular nerve block with local anesthetic immediately before hydrodistension can reduce pain during the procedure, improve patient comfort, and potentially enhance clinical outcomes.\n\nParticipants will be randomly assigned to one of two groups:\n\nhydrodistension alone, or\n\nsuprascapular nerve block followed by hydrodistension.\n\nPain, shoulder mobility, functional ability, psychological measures, and quality of life will be assessed at baseline, 1 month, and 3 months after the procedure. The study aims to determine whether adding a suprascapular nerve block provides better tolerability and improved recovery for patients with adhesive capsulitis.",[28,260,261,58,88,262],"Adhesive Capsulitis of Unspecified Shoulder","Adhesive Capsulitis, Shoulder","Shoulder Stiffness",[264,265,88,266,267,268,269],"Shoulder Hydrodistension","Suprascapular Nerve Block","Shoulder Mobility","Randomized Clinical Trial","Pain Management","Rehabilitation","NOT_YET_RECRUITING","2026-01-26",{"date":273,"type":35},"2026-02-02",{"date":275,"type":22},"2026-03-01",{"date":277,"type":22},"2028-07-31",{"name":279,"class":42},"Universidade do Porto",{"id":281,"slug":4,"hasResults":11,"nctId":282,"briefTitle":283,"officialTitle":284,"acronym":285,"eligibilityCriteria":286,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":138,"enrollmentInfo":287,"targetDuration":4,"studyType":23,"phases":288,"briefSummary":289,"conditions":290,"keywords":291,"overallStatus":270,"whyStopped":4,"lastUpdateSubmitDate":295,"lastUpdatePostDateStruct":296,"startDateStruct":298,"completionDateStruct":300,"leadSponsor":302,"locationsCount":43},"100617792","NCT07323225","Neural Mobilization and Capsular Stretching in Adhesive Capsulitis","Effectiveness of Combined Neural Mobilization Techniques and Capsular Stretching Exercises in Patients With Adhesive Capsulitis.","RCT","Inclusion Criteria:\n\n* Patients from both gender (male \\&female) will be included if they would have second or third stage AC with their age between forty and seventy years\n* experiencing pain, capsular adhesions, and a reduction of greater than fifty percentage in passive ROM of the GH joint (external rotation, abduction, and internal rotation compared to the sound side\n* lasting for a minimum of three months. Patients with positive upper limb tension test-1 will be also included in this study\n\nExclusion Criteria:\n\n* they would have stroke,Parkinson's diseases that interfere with shoulder muscles activity\n* diabetes\n* traumatic shoulder conditions\n* glenohumeral osteoarthritis confirmed by x-ray\n* previous surgery, and manipulation of the affected GH joint under general anesthesia\n* Patients with passive elbow extension ROM",{"count":205,"type":22},[25],"Restriction of glenohumeral (GH) mobility in patients with adhesive capsulitis (AC) was known owing to capsular adhesion. There is a little evidence about the involvement of neural restriction in limiting range of motion (ROM) of the GH joint in patients with AC. Objectives: The purpose of this study is to investigate the combined effect of median nerve mobilization and capsular stretching on improving shoulder external rotation, abduction and internal rotation ROM among patients with AC. Methods Thirty patients will be randomly assigned into two equal groups : Group (A) will receive median nerve mobilization and capsular stretching while Group (B) will receive only capsular stretching (anterior, posterior and anteroinferior capsular stretching). Both groups will receive passive and self-assisted exercises. All patients in both groups will be evaluated pre and post treatment for GH external rotation, abduction and internal rotation ROM.",[28],[292,293,294],"Adhesive capsulitis","neural mobilization","capsular stretch","2025-12-28",{"date":297,"type":35},"2026-01-07",{"date":299,"type":22},"2026-01-01",{"date":301,"type":22},"2026-04-10",{"name":303,"class":42},"Prince Sattam Bin Abdulaziz University",{"id":305,"slug":4,"hasResults":11,"nctId":306,"briefTitle":307,"officialTitle":308,"acronym":4,"eligibilityCriteria":309,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":310,"enrollmentInfo":311,"targetDuration":4,"studyType":23,"phases":313,"briefSummary":314,"conditions":315,"keywords":316,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":295,"lastUpdatePostDateStruct":319,"startDateStruct":321,"completionDateStruct":322,"leadSponsor":323,"locationsCount":43},"100519264","NCT06041282","Conservative Treatment of Early Adhesive Capsulitis","A Multicentre Randomized Controlled Trial of Manipulation Under Anesthesia and Supervised Home Rehabilitation in the Treatment of Early Adhesive Capsulitis","Inclusion Criteria:\n\n* Patients in our hospital who need manual release of periarthritis of shoulder or home rehabilitation treatment;\n* Unilateral and primary periarthritis of shoulder\n* Age ≥40 years old and ≤80 years old, regardless of gender.\n* Forward flexion movement is more than 50% limited compared with the contralateral.\n* Duration of disease ≤3 months\n\nExclusion Criteria:\n\n* Patients with a previous history of shoulder joint surgery\n* Patients who did not complete the follow-up within the specified time\n* Patients with other shoulder diseases.\n* Patient with systemic immune disease.\n* Patients who have participated in clinical trials or are conducting other clinical trials within 3 months before screening\n* Patients with serious primary cardiovascular diseases, lung diseases, endocrine and metabolic diseases, or serious diseases affecting their survival, such as tumor or AIDS, are considered not suitable for admission.\n* Patients with serious liver diseases, kidney diseases, hematological diseases, such as kidney function (BUN, Cr) more than the upper limit of normal, liver function (ALT, AST, TBIL) more than 2 times the upper limit of normal.\n* Patients with viral hepatitis, infectious diseases, abnormal blood coagulation mechanism and other diseases that researchers consider inappropriate for surgery.\n* Pregnant or lactating women, or those planning to get pregnant during the test, with positive urine HCG test results before the test; Menstruating women should wait until their period is over before undergoing surgery.\n* Patients with severe neurological and mental diseases.\n* Suspected or true history of alcohol and drug abuse.","80 Years",{"count":312,"type":22},300,[25],"A prospective, multicentre, randomized controlled study comparing the efficacy of conservative treatment for early adhesive capsulitis",[28],[317,318],"manipulation under anesthesia","supervised home rehabilitation",{"date":320,"type":35},"2026-01-02",{"date":299,"type":22},{"date":216,"type":22},{"name":324,"class":42},"Second Affiliated Hospital, School of Medicine, Zhejiang University",{"id":326,"slug":4,"hasResults":11,"nctId":327,"briefTitle":328,"officialTitle":328,"acronym":4,"eligibilityCriteria":329,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":330,"enrollmentInfo":331,"targetDuration":4,"studyType":23,"phases":333,"briefSummary":334,"conditions":335,"keywords":336,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":337,"lastUpdatePostDateStruct":338,"startDateStruct":340,"completionDateStruct":342,"leadSponsor":344,"locationsCount":43},"100618182","NCT07328295","Additional Effects of Thoracic Spine Mobilization Combined With Glenohumeral Joint Mobilization on Pain, Range of Motion, and Functional Disability in Adhesive Capsulitis","Inclusion Criteria:\n\n* • Both male and female patients with a primary complaint of unilateral or bilateral shoulder pain\n\n  * Pain has persisted for at least 3 to 4 months\n  * Decreased shoulder ROM observed, including external shoulder rotation, abduction, internal rotation, and flexion\n  * Age range between 40 to 65 years\n  * Diagnosed with stage 2nd or 3rd of the disease.\n\nExclusion Criteria:\n\n* • Patients if they had any shoulder pain resulting from systematic disease such as Rheumatoid Arthritis (morning stiffness \\> 1 hour, multiple small joints pain\u002Fswelling) Infection, Tumors, and conditions like myelopathy (Hoffman's sign).\n\n  * Recent shoulder joint fracture\u002F trauma.\n  * Thoracic Outlet Syndrome (Roos test).\n  * The presence of Cervical radiculopathy (Spurling's test)","65 Years",{"count":332,"type":22},34,[25],"Adhesive capsulitis is a debilitating shoulder condition characterized by pain, restricted range of motion (ROM), and significant functional limitations. Conventional treatment primarily targets the glenohumeral joint, often neglecting the role of regional interdependence, particularly the thoracic spine's influence on shoulder mobility. Emerging evidence suggests that thoracic spine mobility plays a crucial role in optimizing shoulder mechanics, yet its therapeutic application in adhesive capsulitis remains underexplored. This study aims to investigate the additional effects of thoracic spine mobilization combined with glenohumeral joint mobilization, providing a more comprehensive rehabilitation approach to enhance pain relief, ROM, and functional outcomes.\n\nA randomized controlled trial (RCT) will be conducted over one year at the Rehabilitation Department of Fauji Foundation Hospital (FFH) after obtaining ethical approval. Participants diagnosed with adhesive capsulitis will be selected through non-probability purposive sampling based on predefined inclusion and exclusion criteria. Subjects will be randomly assigned to either the experimental group receiving thoracic spine mobilization alongside glenohumeral joint mobilization or the control group receiving glenohumeral joint mobilization alone. Randomization will be conducted using the coin toss method and block randomization to ensure balanced subject distribution.\n\nOutcome measures include the Numeric Pain Rating Scale (NPRS) for pain assessment, the Shoulder Pain and Disability Index (SPADI) for functional disability evaluation, and a goniometer for ROM measurement. Baseline and post-treatment scores will be statistically analyzed using SPSS to determine intervention effectiveness. By integrating thoracic spine mobilization into standard treatment, this study seeks to refine clinical rehabilitation protocols, improve functional recovery, and enhance patient outcomes. Findings may contribute to evidence-based practice, supporting the inclusion of thoracic spine mobilization in treatment guidelines for adhesive capsulitis.",[28],[123],"2025-12-26",{"date":339,"type":35},"2026-01-09",{"date":341,"type":35},"2025-01-15",{"date":343,"type":22},"2026-01-15",{"name":345,"class":42},"Foundation University Islamabad",{"id":347,"slug":4,"hasResults":11,"nctId":348,"briefTitle":349,"officialTitle":350,"acronym":4,"eligibilityCriteria":351,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":138,"enrollmentInfo":352,"targetDuration":4,"studyType":23,"phases":354,"briefSummary":355,"conditions":356,"keywords":357,"overallStatus":270,"whyStopped":4,"lastUpdateSubmitDate":362,"lastUpdatePostDateStruct":363,"startDateStruct":364,"completionDateStruct":366,"leadSponsor":368,"locationsCount":4},"100614701","NCT07283016","Effects of Pectoralis Minor Exercises on Shoulder Pain, Scapular Dyskinesis and Thoracic Expansion in Adhesive Capsulitis Patients","Effects of Pectoralis Minor Stretching and Strengthening Exercises on Shoulder Pain, Scapular Dyskinesis and Thoracic Expansion Among Patients With Adhesive Capsulitis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age: 40 - 70 years\n* Gender: Both Male \\& Female\n* Clinical diagnosis of adhesive capsulitis (Thawing stage).\n* Reduced thoracic expansion.\n* Scapular dyskinesis\n\nExclusion Criteria:\n\n* Presence of rotator cuff tear, labral tears, or glenohumeral arthritis confirmed through imaging\n* Post-stroke hemiparesis,\n* Winged scapula due to lesions of long thoracic nerve or spinal accessory nerve.\n* Rotator cuff repair\n* Capsular release\n* Arthroplasty",{"count":353,"type":22},70,[25],"The goal of the current study is to evaluate the effects of pectoralis minor stretching and strengthening with mobility and stability exercises in patients aged 40-70 years with adhesive capsulitis. The main questions it aims to answer are:\n\nDoes the combination of pectoralis minor stretching and strengthening with mobility and stability exercises significantly reduce shoulder pain compared to mobility and stability exercises only? Does the combination of pectoralis minor stretching and strengthening with mobility and stability exercises improve scapular dyskinesis (scapular movement patterns) and thoracic expansion more effectively than mobility and stability exercises? Participants will be assigned to either an experimental group receiving pectoralis minor stretching and strengthening exercises with mobility and stability exercises or a control group receiving mobility and stability exercises only, and will complete standardized assessments of shoulder pain, scapular dyskinesis (scapular movement patterns) and thoracic expansion before and after the intervention.",[28],[358,359,88,360,361],"Strengthening exercises","Scapular dyskinesis","Thoracic Expansion","Pectoralis minor","2025-12-11",{"date":37,"type":35},{"date":365,"type":22},"2025-12",{"date":367,"type":22},"2026-03",{"name":369,"class":42},"Lahore University of Biological and Applied Sciences",{"id":371,"slug":4,"hasResults":11,"nctId":372,"briefTitle":373,"officialTitle":374,"acronym":4,"eligibilityCriteria":375,"healthyVolunteers":11,"sex":17,"minAge":51,"maxAge":330,"enrollmentInfo":376,"targetDuration":4,"studyType":23,"phases":378,"briefSummary":379,"conditions":380,"keywords":384,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":385,"lastUpdatePostDateStruct":386,"startDateStruct":388,"completionDateStruct":390,"leadSponsor":392,"locationsCount":43},"100611103","NCT07236229","The Effects of Immersive Virtual Reality in Patients With Grade 1-2 Adhesive Capsulitis","The Effects of Immersive Virtual Reality-Based Exercise Therapy on Pain, Functionality, Sleep, and Cognitive Functions in Patients With Grade 1-2 Adhesive Capsulitis","Inclusion Criteria:\n\n* Diagnosed with adhesive capsulitis by a doctor\n* Classified as Grade 1-2 adhesive capsulitis\n* Receiving physiotherapy for adhesive capsulitis for the first time\n* Aged between 18 and 64 years\n* Suitable for using a VR headset\n\nExclusion Criteria:\n\n* Previous history of physiotherapy\n* Presence of any mental disorder\n* Recent surgery or any shoulder condition (e.g., fractures around the shoulder region) that contraindicates shoulder mobilization\n* History of receiving injections",{"count":377,"type":22},36,[25],"Adhesive capsulitis (frozen shoulder) is a complex condition characterized by inflammation, fibrosis, and restriction of movement in the shoulder capsule, significantly limiting an individual's participation in daily living activities. It is most commonly observed in individuals aged between 40 and 60 years, and its treatment frequently involves approaches such as manual therapy, exercise, corticosteroid injections, and electrotherapy. However, these conventional methods may be limited by factors such as lack of motivation, pain-related avoidance behavior, and poor treatment adherence.\n\nToday, immersive virtual reality technologies introduce a new dimension to rehabilitation by gamifying exercise, providing sensory feedback, and enabling graded exposure through mechanisms such as distraction and engagement. They also enhance motivation and compliance with exercise programs. Studies in the literature have reported that virtual reality-based exercise is an effective method for reducing pain levels in patients diagnosed with frozen shoulder.\n\nHowever, only a limited number of studies have specifically examined the effects of immersive virtual reality in patients with adhesive capsulitis. To date, no study has investigated the impact of immersive virtual reality interventions on sleep and cognitive functions in these patients. Furthermore, the combined effect of patient education, home exercise programs, and immersive virtual reality therapy has not yet been explored. For these reasons, the present study aims to investigate the effects of immersive virtual reality-based exercise therapy on pain, functionality, sleep, and cognitive functions in patients with Grade 1-2 adhesive capsulitis.",[28,381,382,185,383],"Virtual Reality","Sleep","Cognition",[28,381,382,185,383],"2025-11-27",{"date":387,"type":35},"2025-12-01",{"date":389,"type":22},"2025-11-28",{"date":391,"type":22},"2026-02-27",{"name":393,"class":42},"Bahçeşehir University",{"id":395,"slug":4,"hasResults":11,"nctId":396,"briefTitle":397,"officialTitle":398,"acronym":4,"eligibilityCriteria":399,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":400,"targetDuration":4,"studyType":23,"phases":401,"briefSummary":402,"conditions":403,"keywords":404,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":408,"lastUpdatePostDateStruct":409,"startDateStruct":411,"completionDateStruct":413,"leadSponsor":415,"locationsCount":43},"100608623","NCT07203963","Additional Effects of Niel-asher Technique on Patients With Adhesive Capsulitis","Additional Effects of Niel Asher Technique Along With Sleeper Stretch on Posterior Capsule in Patients With Adhesive Capsulitis.","Inclusion Criteria:\n\n* Age 40-60 years\n* Both Genders: Male and Female\n* Patient falls under diagnostic criteria for adhesive capsulitis which is Painful and limited active and passive glenohumeral ROM in capsular pattern (external rotation\\> abduction\\> internal rotation)\n* Patient diagnosed with adhesive capsulitis by orthopedic or general physician\n* Patient with phase two and three of adhesive capsulitis based on duration of symptoms\n* Patients of adhesive capsulitis with presence of trigger points in rotator cuff muscles and deltoid muscle (trigger points present in at least 1 or 2 of these muscles) based on simon and travell's criteria of trigger points diagnosis.\n\nExclusion Criteria:\n\n* Spinal Injuries and any other co- morbidity\n* Any surgery, infection, trauma, pregnancy, fracture and fall\n* Patient with intra articular steroidal therapy with in last 6 months\n* Patient unwilling to comply follow up schedule\n* Patient involvement in another intervention study\n* Malignancy\n* Patient with thyroid disorders and RA and Glenohumeral OA\n* History of previous surgery or manipulation under anesthesia of affected shoulder\n* Patient with duration of symptoms of less than three months",{"count":377,"type":22},[25],"The aim of this randomized controlled trial is to find the additional effects of Niel-Asher technique along with sleeper stretch and conventional physical therapy on pain, shoulder ranges of motion and functional disability in patients with Adhesive capsulitis",[28],[405,406,407],"Niel-Asher Technique (NAT)","Sleeper stretch","trigger points","2025-11-18",{"date":410,"type":35},"2025-11-24",{"date":412,"type":35},"2025-10-25",{"date":414,"type":22},"2026-09-20",{"name":41,"class":42},{"id":417,"slug":4,"hasResults":11,"nctId":418,"briefTitle":419,"officialTitle":419,"acronym":4,"eligibilityCriteria":420,"healthyVolunteers":16,"sex":17,"minAge":51,"maxAge":4,"enrollmentInfo":421,"targetDuration":4,"studyType":23,"phases":423,"briefSummary":425,"conditions":426,"keywords":428,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":435,"lastUpdatePostDateStruct":436,"startDateStruct":438,"completionDateStruct":440,"leadSponsor":442,"locationsCount":43},"100230929","NCT02283996","Adhesive Capsulitis: Prospective Analysis of Efficacy and Financial Impact for Use of Physical Therapy in Treatment","Inclusion Criteria:\n\n* Patient must be 18 years or older\n* Must meet the following definition for adhesive capsulitis as defined by the American Academy of Orthopedic Surgeons: Self-limiting condition resulting from any inflammatory process about the shoulder in which capsular scar tissue is produced, resulting in pain and limited range of motion; also called frozen shoulder\n* Must be amenable to randomization into either cohort\n\nExclusion Criteria:\n\n* Non-English speaking patients\n* Pregnant women (women of childbearing potential will be advised to undergo regular pregnancy testing)\n* Patients who had previously undergone operative therapy for the condition",{"count":422,"type":22},260,[424],"PHASE4","The purpose of this study is to identify individuals 18 or older who have diagnostic presentation of adhesive capsulitis and randomize them into two arms, distinguished by use of physical therapy and steroid injections compared with steroid injections followed by watchful waiting. This prospective study will be used to determine whether there is a significant impact on patient outcome and whether the additional financial burden is justified. There are no experimental interventions for this study. The use of physical therapy, oral and parenteral corticosteroids, and watchful waiting are offered following the standard of care for adhesive capsulitis. Our hypothesis is that patients will not have a significant difference in outcome between the two study arms. One group will undergo regular physical therapy with corticosteroid injections (Arm 1) and the other will have steroid injections during the inflammatory phase only and then be regularly observed (Arm 2). We also hypothesize there will be a significant financial burden associated with the PT arm that is not justified with the possibility of increased symptom reports in that arm.",[28,58,427],"Shoulder Frozen",[28,58,427,429,430,431,432,433,434],"Physical Therapy","Corticosteroid Injections","Hydrodilation, Hydro-dilation","Watchful Waiting","Prospective","Glenohumeral Ligament","2025-10-24",{"date":437,"type":35},"2025-10-27",{"date":439,"type":35},"2014-11",{"date":441,"type":22},"2027-12",{"name":443,"class":42},"Massachusetts General Hospital",{"id":445,"slug":4,"hasResults":11,"nctId":446,"briefTitle":447,"officialTitle":448,"acronym":4,"eligibilityCriteria":449,"healthyVolunteers":11,"sex":17,"minAge":137,"maxAge":330,"enrollmentInfo":450,"targetDuration":4,"studyType":23,"phases":451,"briefSummary":452,"conditions":453,"keywords":457,"overallStatus":270,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":463,"startDateStruct":465,"completionDateStruct":467,"leadSponsor":469,"locationsCount":43},"100605543","NCT07163884","The Effect of Fascial Treatment in Patients With Adhesive Capsulitis","Adheziv kapsülit tanılı Hastalarda Fasyal Tedavinin ağrı, Normal Eklem Hareket açıklığı, Propriosepsiyon ve Fasya Mimarisine Etkisinin araştırılması","Inclusion Criteria:\n\n* Patients diagnosed with adhesive capsulitis by a specialist,\n* Patients between the ages of 35 and 60,\n* Those not diagnosed with cervical disc herniation that could cause other shoulder pathologies,\n* Those who have not participated in an upper extremity-related physiotherapy program within the last 6 months,\n* Individuals who volunteer to participate in the study,\n\nExclusion Criteria:\n\n* Individuals who have undergone shoulder surgery consistent with any pathology,\n* Individuals with a neurological history,\n* Individuals diagnosed with diabetes mellitus (DM)",{"count":377,"type":22},[25],"Our study is unique in that it utilizes a self-designed fascial mobilization protocol and ultrasonographic evaluation for adhesive capsulitis. Therefore, the aim of our study is to investigate the effects of fascial therapy on pain, normal joint range of motion, proprioception, and fascial architecture in patients diagnosed with adhesive capsulitis.",[28,454,455,456],"Ultrasonography","Fascia","Treatment (ProudMe)",[458,459,460,461,462],"adhezsiv capsulitis","pain","range of motion","proprioception","fascia architecture",{"date":464,"type":35},"2025-09-09",{"date":466,"type":22},"2025-09-15",{"date":468,"type":22},"2025-11-15",{"name":470,"class":42},"Hasan Kalyoncu University",{"id":472,"slug":4,"hasResults":11,"nctId":473,"briefTitle":474,"officialTitle":475,"acronym":4,"eligibilityCriteria":476,"healthyVolunteers":11,"sex":17,"minAge":137,"maxAge":330,"enrollmentInfo":477,"targetDuration":4,"studyType":23,"phases":479,"briefSummary":480,"conditions":481,"keywords":483,"overallStatus":270,"whyStopped":4,"lastUpdateSubmitDate":487,"lastUpdatePostDateStruct":488,"startDateStruct":490,"completionDateStruct":491,"leadSponsor":492,"locationsCount":43},"100605110","NCT07158255","Effects of Exercise on Adhesive Capsulitis","Effect of Exercise Training on Pain, Range of Motion, Functionality and Shoulder Architecture in Patients With Adhesive Capsulitis","Inclusion Criteria:\n\n* Diagnosed with adhesive capsulitis by a physician,\n* Between the ages of 35-60,\n* Not diagnosed with cervical disc herniation that could cause other shoulder pathologies,\n* Not participating in an upper extremity-related physiotherapy program within the last 6 months,\n* Volunteering individuals to participate in the study\n\nExclusion Criteria:\n\n* Individuals who have undergone shoulder surgery consistent with any pathology,\n* Individuals with a neurological history,\n* Individuals diagnosed with diabetes mellitus (DM)",{"count":478,"type":22},32,[25],"Our study aims to investigate the effects of exercise training on pain, range of motion, functionality and shoulder architecture in patients with adhesive capsulitis.",[28,482,454],"Exercise",[458,459,460,484,485,486],"functionality","shoulder architecture","exercise","2025-08-28",{"date":489,"type":35},"2025-09-05",{"date":489,"type":22},{"date":468,"type":22},{"name":470,"class":42},{"id":494,"slug":4,"hasResults":11,"nctId":495,"briefTitle":496,"officialTitle":497,"acronym":498,"eligibilityCriteria":499,"healthyVolunteers":11,"sex":17,"minAge":51,"maxAge":4,"enrollmentInfo":500,"targetDuration":4,"studyType":23,"phases":502,"briefSummary":503,"conditions":504,"keywords":505,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":507,"lastUpdatePostDateStruct":508,"startDateStruct":510,"completionDateStruct":512,"leadSponsor":513,"locationsCount":43},"100603245","NCT07134010","The Impact of Perineural Injection Therapy for Adhesive Capsulitis.","The Impact of Perineural Injection Therapy for Adhesive Capsulitis at a Single Centre University Hospital in Selangor: A Pilot Study","PIT; AC","Inclusion Criteria:\n\n1. Age 18 and above.\n2. Diagnosed with primary adhesive capsulitis by a specialist.\n3. Limitation of range of motion ≥ 50% relative to the normal side or normal reference (in patient with bilateral adhesive capsulitis) in three or more movement directions (i.e., external rotation, abduction, forward flexion, and internal rotation).\n4. Chronic adhesive capsulitis shoulder pain lasting for at least 3 months.\n5. Pain score of at least 4\u002F10 on the Numerical Rating Scale (NRS) during movement, indicating at least moderate pain severity.\n6. Consented to the study.\n\nExclusion Criteria:\n\n1. Received any shoulder pain injection within the past 6 weeks or surgical intervention such manipulation under anesthesia, arthroscopic capsular release, or open surgery for capsular release.\n2. Diagnosed with other shoulder pathology such as neurologic deficits affecting shoulder function, tumour, rotator cuff injury or fracture.\n3. Has history of allergy to dextrose solution.\n4. Patients receiving steroidsimmunosuppressants, psychotropic medication, or other medications that may affect, the clinical outcomes\n5. Patients with haemorrhagic disease, taking anticoagulant drugs, or patients with severe diabetes mellitus having an increased risk of infection (HBA1c \\>8%)\n6. Do not understand Malay or English language.\n7. Unable to follow a 3 steps command.",{"count":501,"type":22},24,[25],"The goal of this clinical trial is to learn if Perineural Injection Therapy (PIT) works to treat adhesive capsulitis (frozen shoulder) in adults. It will also learn about the safety of PIT.\n\nThe main questions it aims to answer are:\n\nDoes PIT reduce shoulder pain and improve shoulder range of motion more effectively than conventional therapy alone?\n\nWhat side effects or medical problems do participants experience when receiving PIT?\n\nResearchers will compare PIT to conventional therapy to see if PIT works better to treat adhesive capsulitis.\n\nParticipants will:\n\nReceive either:\n\nPIT once weekly for 6 weeks plus physiotherapy and oral analgesics (excluding NSAIDs), or\n\nConventional therapy only (physiotherapy and analgesics including NSAIDs)\n\nAttend scheduled follow-up visits at Week 6, 1 month, and 3 months after treatment\n\nPerform daily home-based shoulder exercises and record their analgesic use and any side effects in a patient diary",[28],[506],"Perineural injection therapy in treating Adhesive Capsulitis","2025-08-27",{"date":509,"type":35},"2025-09-04",{"date":511,"type":35},"2025-06-03",{"date":69,"type":22},{"name":514,"class":42},"Universiti Teknologi Mara",{"id":516,"slug":4,"hasResults":11,"nctId":517,"briefTitle":518,"officialTitle":519,"acronym":4,"eligibilityCriteria":520,"healthyVolunteers":11,"sex":17,"minAge":137,"maxAge":330,"enrollmentInfo":521,"targetDuration":4,"studyType":23,"phases":522,"briefSummary":523,"conditions":524,"keywords":525,"overallStatus":270,"whyStopped":4,"lastUpdateSubmitDate":530,"lastUpdatePostDateStruct":531,"startDateStruct":533,"completionDateStruct":535,"leadSponsor":537,"locationsCount":43},"100599097","NCT07080060","Comparison of Niel-Asher and Spencer Techniques in Frozen Shoulder Patients","Effects of Niel-Asher Technique Versus Spencer Technique Along With Conventional Therapy on Pain, Range of Motion, and Functional Status in Frozen Shoulder Patients","Inclusion Criteria:\n\n* Age group between 35-65 years diagnosed with primary Adhesive Capsulitis.\n* Both gender male and female.\n* Both Active and passive Range of Motion is limited.\n* Stage II Frozen Shoulder patients (Freezing Stage,3-9 months).\n* More than 50% of range of motion is limited in Flexion, Abduction and External rotation as compared to unaffected side.\n* Pain reported on VAS score \\\u003C7\u002F10 in shoulder region.\n* Patients agree to sign written consent form.\n\nExclusion Criteria:\n\n* Patients with systemic illness:\n* Diabetes Mellitus, Thyroid disorders.\n* Rheumatoid Arthritis, Malignancy.\n* Patients with mechanical injuries like:\n* Rotator Cuff injury, Ligamentous Injuries.23\n* Previous Surgery or Manipulation under Anesthesia.\n* Patients with Stage I, III, IV of Frozen Shoulder.\n* Patient reported with VAS score \\>7\u002F10 in shoulder region.",{"count":180,"type":22},[25],"This study aims to compare the effectiveness of two manual therapy techniques-Niel-Asher Technique and Spencer Technique-when combined with conventional physiotherapy in treating patients with frozen shoulder (adhesive capsulitis). Frozen shoulder is a painful condition that limits movement and function of the shoulder joint. The study will include 44 adults aged 35 to 65 years who have been diagnosed with stage II frozen shoulder. Participants will be randomly assigned to one of two groups. Both groups will receive standard physiotherapy, including heat therapy, TENS, and stretching exercises. In addition, one group will receive the Niel-Asher Technique, while the other group will receive the Spencer Technique. Pain, range of motion, and shoulder function will be measured before and after a 4-week treatment period using validated tools such as the Visual Analogue Scale (VAS), a goniometer, and the Shoulder Pain and Disability Index (SPADI). The goal is to determine which manual therapy technique is more effective in improving symptoms and function in patients with frozen shoulder.",[58,28],[526,527,528,185,529],"Manual Therapy","Niel-Asher Technique","Spencer Technique","Range of motion","2025-07-14",{"date":532,"type":35},"2025-07-23",{"date":534,"type":22},"2025-07",{"date":536,"type":22},"2025-11-30",{"name":41,"class":42},{"id":539,"slug":4,"hasResults":11,"nctId":540,"briefTitle":541,"officialTitle":541,"acronym":4,"eligibilityCriteria":542,"healthyVolunteers":11,"sex":17,"minAge":543,"maxAge":310,"enrollmentInfo":544,"targetDuration":4,"studyType":23,"phases":546,"briefSummary":547,"conditions":548,"keywords":549,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":553,"lastUpdatePostDateStruct":554,"startDateStruct":556,"completionDateStruct":558,"leadSponsor":560,"locationsCount":43},"100596621","NCT07047846","Bowen Technique Versus Dynamic Soft Tissue Mobilization on Pain, Range of Motion and Functional Disability in Patients With Adhesive Capsulitis","Inclusion Criteria:\n\n* Diagnosed patients of 50-80 years of age\n* Grade 2 \\& 3 (frozen and thawing) adhesive capsulitis\n* patients willing to participate in the study\n* Only diabetic patients\n\nExclusion Criteria:\n\n* Major mental health probleme\n* Patients who has a history of surgery on the shoulder, other shoulder diseases including a rotator cuff tear, sub acromial impingement syndrome, and a shoulder labral tear\n* Patients taking oral or intra-articular steroids and cortisone injection prior 3 months\n* Subjects with rotator cuff tears or other shoulder ligament injuries, H\u002FO arthritis related to shoulder, malignancy, adhesive capsulitis secondary to fractures, dislocation, reflex sympathetic dystrophy, neurological disorder","50 Years",{"count":545,"type":22},72,[25],"A randomized controlled trial included 72 patients diagnosed with adhesive capsulitis will conduct in University of Lahore Teaching Hospital. The study will complete within 9 months after the approval of synopsis. Patients who fulfilled the inclusion criteria will identified by individual physiotherapist and will enrolled for particular study. Informed written consent will be taken by the patients and will randomly allocated into two groups. The total numbers of sessions will 12 (3 sessions per week). The study will single blinded. The assessor will unaware of the treatment given to both groups.\n\nControl group received routine physical therapy with dynamic soft tissue mobilization technique.\n\nthermotherapy, trans-cutaneous electrical nerve stimulation, shoulder isometrics and stretching that includes 12 sessions and three times per week. Experimental group received routine physical therapy along with Bowen technique. This includes thermotherapy, trans-cutaneous electrical nerve stimulation, shoulder isometrics and stretching that includes 12 sessions and three times per week",[28],[28,550,551,460,88,552],"Bowen Therapy","Dynamic Soft Tissue Mobilization","physiotherapy","2025-07-01",{"date":555,"type":35},"2025-07-02",{"date":557,"type":22},"2025-07-16",{"date":559,"type":22},"2026-01-03",{"name":561,"class":42},"University of Lahore",{"id":563,"slug":4,"hasResults":11,"nctId":564,"briefTitle":565,"officialTitle":566,"acronym":4,"eligibilityCriteria":567,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":568,"targetDuration":4,"studyType":23,"phases":570,"briefSummary":571,"conditions":572,"keywords":573,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":575,"lastUpdatePostDateStruct":576,"startDateStruct":578,"completionDateStruct":580,"leadSponsor":582,"locationsCount":43},"100591854","NCT06985836","Effect of Mulligan Mobilization With or Without Niel Asher Technique in Patients With Adhesive Capsulitis","Effect of Mulligan Mobilization With or Without Niel Asher Technique on Pain, Range of Motion and Disability in Patients With Adhesive Capsulitis","Inclusion Criteria:\n\n* Age group 40-60 year\n* Both gender male and female\n* Stage 2 primary adhesive capsulitis with capsular pattern of restriction (rotation\\>abduction\\>flexion)\n* Pain in shoulder should be ≤7 on NPRS\n* Patient is willing to perform.\n\nExclusion Criteria:\n\n* • Diabetes\n\n  * Malignancy\n  * Infection\n  * Arthoplasty\n  * Pregnancy\n  * Neurological disorders\n  * Fracture\n  * Thyroid diseases",{"count":569,"type":22},42,[25],"Adhesive capsulitis is a prevalent condition characterized by pain and stiffness in shoulder joint and surrounding muscles shows decrease range and strength in patients with adhesive capsulitis. This study aims to determine the effect of mulligan mobilization with or without Niel Asher technique on pain, range of motion and disability in patients with adhesive capsulitis. This study will be a randomized controlled trial and will be conducted in Ibne-siena Hospital Multan and Multicare physiotherapy clinic. Non-probability convenience sampling will be used to collect the data. Sample size of subjects with age group between 40 to 60 years will be taken. Data will be collected from the patients having present complaint of adhesive capsulitis. Outcome measures used will be Numeric pain rating scale (NPRS) for shoulder pain and SPADI for shoulder disability and Universal Goniometer (GU) for Range of motion. An informed consent will be taken. Subjects will be selected on the basis of inclusion and exclusion criteria. Subjects will be divided into two groups by random number generator table. Both the Groups will receive heating pad, TENS. Group A will receive Mulligan Mobilizations and Neil Asher technique, and Group B will receive Mulligan mobilization and Conventional Treatment. Outcome measures will be measured at baseline and after 4 weeks. Data analysis will be done by SPSS version 26.",[28],[123,122,574],"mannual therapy","2025-05-15",{"date":577,"type":35},"2025-05-22",{"date":579,"type":35},"2024-12-15",{"date":581,"type":22},"2025-06-15",{"name":41,"class":42},{"id":584,"slug":4,"hasResults":11,"nctId":585,"briefTitle":586,"officialTitle":587,"acronym":4,"eligibilityCriteria":588,"healthyVolunteers":11,"sex":17,"minAge":51,"maxAge":4,"enrollmentInfo":589,"targetDuration":4,"studyType":23,"phases":591,"briefSummary":593,"conditions":594,"keywords":595,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":575,"lastUpdatePostDateStruct":596,"startDateStruct":598,"completionDateStruct":600,"leadSponsor":602,"locationsCount":43},"100591149","NCT06976671","A Study to Determine the Safety and Efficacy of Bevacizumab Administered Via Injection Into the Shoulder Joint of Participants With Adhesive Capsulitis (Frozen Shoulder)","A Phase II Proof-of-concept Study Evaluating the Safety and Efficacy of Bevacizumab in the Treatment of Adhesive Capsulitis","Inclusion Criteria:\n\nIC1. Over 18 years of age (inclusive) at the time of signing informed consent\n\nIC2. Clinical diagnosis of adhesive capsulitis which is defined as:\n\n1. Progressive pain and stiffness for a period greater than 2 months but less than 6 months; and,\n2. Either thickening or signal hyperintensity associated with coracohumeral ligament, axillary pouch, or rotator interval joint capsule OR obliteration of the subcoracoid fat triangle as confirmed by radiological examination (magnetic resonance imaging); and,\n3. Normal x-ray of the shoulder with no evidence of glenohumeral joint degenerative changes or sequelae of previous trauma.\n\nIC3. Capable of giving signed informed consent as described in Section 14 of the protocol which includes compliance with the requirements and restrictions listed in the informed consent form and in this protocol\n\nIC4. Participants of child-bearing potential are eligible to participate if they agree to the following during the study intervention period and for a minimum of 120 days after the study intervention is administered:\n\n1. Female participants must not be pregnant or breastfeeding AND are either abstinent from heterosexual intercourse as their preferred usual lifestyle OR engage in an adequate method of contraception (i.e., the oral contraceptive pill, intrauterine device, or other)\n2. Male participants must refrain from donating sperm AND are either abstinent from heterosexual intercourse as their preferred usual lifestyle OR must agree to use an adequate method of contraception\u002Fbarrier method (i.e. condom and\u002For heterosexual partner engaging in an adequate method of contraception as previously described)\n\nIC5. Participants who are not of child-bearing potential, defined as at least one or more of the following criteria, are eligible to participate in the study\n\n1. Female participants in a post-menopausal state (defined as not experiencing menses for 12 consecutive months without an alternative cause)\n2. Documented permanent sterilisation method (including, but not limited to, hysterectomy, bilateral salpingectomy, bilateral oophorectomy, and vasectomy)\n\nExclusion Criteria:\n\nEC1. History of previous surgery or treatment with corticosteroid prior to screening, platelet-rich plasma, or anti-VEGF injections in the ipsilateral shoulder\n\nEC2. History of adhesive capsulitis in ipsilateral shoulder\n\nEC3. Presence of trauma in the affected shoulder unrelated to adhesive capsulitis\n\nEC4 Advanced imaging features associated with calcific tendinopathy\n\nEC5. Presence of uncontrolled hypertension (defined as systolic pressure \\> 140mmHg and diastolic pressure \\> 100mmHg)\n\nEC6. Any medical history of cardiovascular disease, uncontrolled ischemic heart disease, acute myocardial infarction within 12 months of study entry, or any history of intracranial hemorrhage, stroke or a transient ischaemic attacks at any time\n\nEC7. Presence of inflammatory arthritis (such as but not limited to: systemic lupus erythematosus, rheumatoid arthritis, reactive arthritis, etc.), Parkinson's disease, brain injury, osteoarthritis, bony glenohumeral pathology, hypothyroidism, neuromuscular disorders, or pre-diabetes or diabetes mellitus (defined by fasting glucose ≥7mmol\u002FL and Hba1c ≥ 5.7%)\n\nEC8. Participants currently taking corticosteroids, monoclonal antibody therapy, or other immunosuppressants which are deemed to impact the study endpoints\n\nEC9. Planning to or have received treatment for the affected shoulder at any time during the study or prior to the study included but not limited to:\n\n1. Intra-articular or intrabursal injection(s) of lidocaine, suprascapular nerve blocks; corticosteroids, electroanalgesic and\u002For thermoanalgesic modalities\n2. Intra-articular or intrabursal injection(s) of sodium hyaluronate and\u002For glenohumeral distension arthrography\n3. Surgical intervention\n\nEC10. Progressive pain and stiffness in the affected shoulder that is for a period less than 2 months or greater than 6 months\n\nEC11. Hypersensitivity to the study intervention, including any constituents thereof, or drug or other allergy that, in the opinion of the Investigator, contraindicates participation in the study\n\nEC12. Any active malignancy under treatment\n\nEC13. Women who are pregnant and\u002For breastfeeding, or who plan to be pregnant in the following six months after study intervention\n\nEC14. Participants not suitable for participation, whatever the reason, as judged by the Investigator, including medical or clinical conditions that might affect their safety or ability to complete the protocol or that may confound the efficacy or safety results of the trial\n\nEC15. Participants are employees of the clinical study site or other individuals directly involved in the conduct of the study, or immediate family members of such individuals (in conjunction with Section 1.61 of the ICH-GCP Ordinance E6)\n\nEC16. Individuals accommodated in an institution because of regulatory or legal order; prisoners or participants who are legally institutionalised\n\nEC17. Participants unable to provide written informed consent\n\nEC18. Participants who have participated in other clinical trial within 1 month, have participated in another study within 6 months from the date of selection, or have planned for participation in another trial during the follow up period of this trial which is deemed by the Investigator to impact the planned study endpoints of this study\n\nEC19. Acute illness within the 30 days prior to V1 that, in the opinion of the Investigator, affects the participant's ability to participate in the study.\n\nEC20. Participants currently taking warfarin or any other anti-coagulation therapies.\n\nEC21.Participants deemed with any condition which would preclude their use for study-related magnetic resonance imaging procedures, including but not limited to: morbid obesity, severe claustrophobia, and\u002For permanent pacemaker).",{"count":590,"type":22},28,[592],"PHASE2","This study is intended to test a new treatment for a condition called adhesive capsulitis, also known as frozen shoulder. The treatment being tested is called bevacizumab. Participants will receive a single dose of bevacizumab (50mg, 100mg, 150mg, or 200mg) via injection into their shoulder joint. After the injection, participants will return to site 6 times over the course of a year for safety assessments, questionnaires to track pain levels, and range of movement tests conducted by a physiotherapist.\n\nThe main goal of this study is to:\n\n1. Evaluate the safety and effectiveness of bevacizumab when it is injected into the frozen shoulder joint.\n2. Determine the maximum dose of bevacizumab that can be given without side effects.\n\nThis is an investigator initiated clinical trial sponsored by Macquarie University. There will be a maximum of 28 participants enrolled and the only site involved in recruitment is Macquarie University.",[28],[28,58],{"date":597,"type":35},"2025-05-16",{"date":599,"type":35},"2024-09-10",{"date":601,"type":22},"2027-09",{"name":603,"class":42},"Macquarie University, Australia",{"id":605,"slug":4,"hasResults":11,"nctId":606,"briefTitle":607,"officialTitle":607,"acronym":4,"eligibilityCriteria":608,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":609,"targetDuration":4,"studyType":23,"phases":610,"briefSummary":611,"conditions":612,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":613,"lastUpdatePostDateStruct":614,"startDateStruct":616,"completionDateStruct":618,"leadSponsor":620,"locationsCount":43},"100547426","NCT06407817","Comparative Effects Of Spencer and Reverse Distraction Technique In Patients With Adhesive Capsulitis","Inclusion Criteria:\n\n* Age group 40-60 years\n* Male and female\n* Positive Capsular pattern (ER more limited than Abd which is more limited than IR)\n* Limitation in shoulder ROM ; Flexion \\\u003C180 , Abduction \\\u003C180 , External Rotation \\\u003C50\n* Patients of stage 2 and 3 of adhesive capsulitis\n\nExclusion Criteria:\n\n* History of surgery of the affected shoulder\n* Fractures in around the shoulder\n* Neurological disorders leading to altered muscle activity\n* Systemic arthritic conditions (RA, Osteoporosis)\n* Disorders of the cervical spine",{"count":205,"type":22},[25],"To compare the effects of spencer and reverse distraction technique in patients with adhesive capsulitis",[28],"2024-12-20",{"date":615,"type":35},"2024-12-27",{"date":617,"type":35},"2024-02-01",{"date":619,"type":22},"2025-01",{"name":41,"class":42},""]