B Cell Non Hodgkins Lymphoma

8

Review clinical trials related to B Cell Non Hodgkins Lymphoma. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Study to Evaluate the Optimization of the Cytokine Release Syndrome Profile for Glofitamab in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed/Refractory Aggressive B-Cell Non-Hodgkin's Lymphoma

This Phase II trial evaluates the optimization of the cytokine release syndrome (CRS) profile for glofitamab in combination with gemcitabine and oxaliplatin (Glofit-GemOx) in participants with relapsed or refractory aggressive B-cell Non-Hodgkin's lymphoma. The study utilizes an optimized steroid premedication regimen and monitoring schedule specifically designed to enable the administration of the treatment regimen in an outpatient setting.

Participants needed: 100
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Hoffmann-La RocheUpdated: Jun 23, 2026Locations: 53
Eligibility criteria

Histologically confirmed large B-cell lymphoma (de novo or transformed from FL)... [+7]

Prior enrollment in Studies GO41943 (NCT04313608), GO41944 (STARGLO; NCT04408638... [+29]

Status: Recruiting

In VIVO CAR-T Therapy for Relapsed/Refractory Hematological Malignancies

This study is an investigator-initiated single center, single arm clinical study with a target population of patients with relapsed or refractory malignant hematological tumors. It is an early exploratory clinical study of the safety, tolerability and initial efficacy in the treatment of relapsed or refractory malignant hematological tumors.

Participants needed: 24
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Chongqing Precision Biotech Co., LtdUpdated: Nov 20, 2025Locations: 1
Eligibility criteria

Age ≥ 18 years old, gender unrestricted; [+8]

History of hematopoietic stem cell transplantation: Received allogeneic or autol... [+12]

Status: Recruiting

JS203 Combination Regimens in B-Cell Non-Hodgkin's Lymphoma

To evaluate the preliminary efficacy of JS203 combined with standard regimens in patients with B-cell Non-Hodgkin's lymphoma

Participants needed: 180
Trial details
Phase: Phase 2Age: 18-80Biological sex: AllType: InterventionalSponsor: Shanghai Junshi Bioscience Co., Ltd.Updated: Aug 21, 2025Locations: 1
Eligibility criteria

Age range: 18 to 80 years old (inclusive), both male and female are acceptable; [+3]

A history of severe allergy to monoclonal antibody therapy (or recombinant antib... [+8]

Status: Not yet recruiting

A Phase I Clinical Trial of RS001 in Patients with Relapsed/Refractory B-Cell Malignancies

This study is an open-label, single-arm, dose-escalation and dose-expansion study to evaluate the safety, maximum tolerated dose, pharmacokinetic profile in the body after infusion of RS001 injection, and preliminary efficacy in subjects with CD19-positive relapsed/refractory B-cell malignancies (BCM).

Participants needed: 13
Trial details
Phase: Phase 1Age: 18-75Biological sex: AllType: InterventionalSponsor: Guangdong Ruishun Biotech Co., LtdUpdated: Mar 25, 2025
Eligibility criteria

Voluntarily sign an ICF and expect to complete the subsequent follow-up. [+16]

Other malignancies within 5 years prior to screening, except adequately treated... [+16]

Status: Not yet recruiting

A Tolerability, Safety and Efficacy Study of RJMty19 in Subjects With Relapsed or Refractory B-NHL

This is a Phase 1, open-label, single-arm study to evaluate tolerability, safety and efficacy of RJMty19 in adult subjects with r/r B-NHL.

Participants needed: 30
Trial details
Phase: Phase 1Age: 18-65Biological sex: AllType: InterventionalSponsor: Guangdong Ruishun Biotech Co., LtdUpdated: Mar 18, 2024
Eligibility criteria

Voluntarily sign an ICF and expect to complete the subsequent follow-up. [+26]

Other malignancies within 5 years prior to screening, except adequately treated... [+15]

Status: Recruiting

A Trial of SHR-A1912 Combined With Other Therapies in B-cell Non-Hodgkin 's Lymphoma

This study aims to evaluate the safety, PK and preliminary anti-tumour activity of SHR-A1912 combined with other therapies in patients with B-cell non-Hodgkin 's lymphoma.

Participants needed: 132
Trial details
Phase: Phase 1, Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Shanghai Hengrui Pharmaceutical Co., Ltd.Updated: Dec 27, 2023Locations: 1
Eligibility criteria

Age greater than or equal to18 years old; [+5]

Received autologous stem cell transplantation within 12 weeks before the first s... [+7]

Status: Recruiting

Human CD19 Targeted T Cells Injection(CD19 CAR-T) Therapy for Relapsed and Refractory B-cell Non-Hodgkin's Lymphoma

A Phase Ⅱ Clinical Study Evaluating the Efficacy and Safety of Human CD19 Targeted T Cells Injection (CD19 CAR-T) Therapy for R/R B-NHL. Patients will be given a conditioning chemotherapy regimen of fludarabine and cyclophosphamide followed by a single infusion of CD19 CAR+ T cells.

Participants needed: 100
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Hrain Biotechnology Co., Ltd.Updated: Jul 5, 2022Locations: 1
Eligibility criteria

Age≥18 years old,gender is not limited; [+13]

Malignant tumors other than diffuse large B-cell lymphoma (DLBCL), primary media... [+11]

Status: Not yet recruiting

A Phase 1/2 Study of CT120 in Patient With Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma

This study is a single-armed, open-label,multicenter Phase 1/2 study to evaluate the safety and efficacy of CT120 in subjects with relapsed/refractory B-cell non-Hodgkin's lymphoma.

Participants needed: 125
Trial details
Phase: Phase 1, Phase 2Age: 18-70Biological sex: AllType: InterventionalSponsor: Nanjing IASO Biotechnology Co., Ltd.Updated: Oct 25, 2021
Eligibility criteria

Age between 18 and 70 years old. [+11]