[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"beta-amyloid\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:beta-amyloid":126},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,55,84],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100474761",false,"NCT05462106","A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)","A Phase 1b\u002F2, Multicenter, Adaptive, Double-blind, Randomized, Placebo-controlled Study to Assess the Safety, Tolerability, Immunogenicity, and Pharmacodynamic Effects of ACI-24.060 in Subjects With Prodromal Alzheimer's Disease and in Adults With Down Syndrome (ABATE)","Inclusion Criteria:\n\nStudy Part 1a and Part 1b\n\n1. Age ≥50 and ≤85 years at screening.\n2. Diagnosis of prodromal AD: MCI due to AD according to National Institute on Aging Alzheimer's Association (NIA-AA) criteria.\n3. PET scan at screening consistent with the presence of amyloid pathology.\n4. Clinical Dementia Rating (CDR)-Global Score of 0.5.\n5. Subjects either not taking any marketed treatment for AD or receiving a stable dose of an acetylcholinesterase inhibitor (ACHEI) and\u002For memantine for at least 2 months prior to screening.\n\nStudy Part 2\n\n1. Age ≥35 and ≤50 years at screening (subjects with DS with age ≥35 and ≤39 years may be considered on the condition that there is prior evidence of amyloid results compatible with AD pathology at PET-scan and\u002For in biofluids).\n2. Male or female subjects with DS with a cytogenetic diagnosis being either trisomy 21 or complete unbalanced translocation of chromosome 21.\n3. PET scan at screening consistent with the presence of amyloid pathology.\n4. Mild to moderate intellectual disability as per Diagnostic and Statistical Manual of Mental Disorders (DSM-5) classification.\n5. Subjects must have a study partner who has direct and regular contact, at least 10 hours per week, with the subject and who is able to provide reliable answers to questions related to the subject, according to the study investigator.\n\nExclusion Criteria:\n\n1. Any unstable and\u002For clinically significant medical condition likely to hamper the evaluation of safety and\u002For efficacy of the study treatment (eg, moderate and\u002For severe untreated obstructive sleep apnea, clinically significant reduction in serum B12 or folate levels, clinically significant abnormalities of thyroid function, stroke, or other cerebrovascular conditions), as per investigator's judgement.\n2. DSM-5 criteria for substance use disorders drug or alcohol abuse or dependence (with the exception of tobacco use disorder) currently met within the past 5 years.\n3. History or presence of uncontrolled seizures. If there is a history of seizures, they must be well controlled, with no occurrence of seizures in the 2 years before study screening. The use of antiepileptic medications is permitted.\n4. Concomitant or history of clinically significant and\u002For unstable psychiatric or neurologic disorder other than those considered to be related to AD (eg, head injury with loss of consciousness, symptomatic stroke, Parkinson's disease, severe carotid occlusive disease, transient ischemic attacks, hemorrhagic and\u002For non-hemorrhagic stroke). Subjects with a history of major depressive disorder may be included if they have been free of major episodes for at least 1 year before screening.\n5. History of meningitis or meningoencephalitis.\n6. History of moderate or severe traumatic brain injury.\n7. History or presence of inflammatory neurological disorders.\n8. History or presence of immunological or autoimmune disorders.\n9. History of severe allergic reaction (eg, anaphylaxis) including, but not limited to severe allergic reaction to previous vaccines, foods, and\u002For medications.\n10. Significant risk of suicide, defined using the C-SSRS as the subject answering \"yes\" to suicidal ideation questions 4 or 5 or answering \"yes\" to suicidal behavior within the past 12 months.\n11. MRI scan at screening showing a single area of cerebral vasogenic edema, superficial siderosis, or evidence of a previous macro-hemorrhage or showing more than 4 cerebral microhemorrhages (regardless of their anatomical location or diagnostic characterization as \"possible\" or \"definite\"). Evidence of space occupying lesions other than benign meningioma of less than 1 cm diameter, more than 2 lacunar infarcts, or 1 single infarct larger than 1 cm in diameter. Screening MRI scan showing structural evidence of alternative pathology not consistent with AD and is considered to be at the origin of subject's symptoms.\n12. Deviations from normal values for hematologic parameters, liver function tests, and other biochemical measures, judged to be clinically significant by the investigator.\n13. Subjects with a positive Human Immunodeficiency Virus (HIV-1 and 2) test at screening.\n14. Subjects with clinical or laboratory evidence of active hepatitis B or C at screening (eg, HBV or HCV antigens).\n15. Subjects with positive syphilis serology consistent with active syphilis at screening.\n16. Subjects with presence of antibody titers related to immunological or autoimmune disorders at screening.\n17. MRI examination cannot be done for any reason, including but not limited to metal implants contraindicated for MRI and\u002For severe claustrophobia.\n18. Any contraindication for PET scan imaging.\n19. Any contraindication to lumbar puncture in subjects undergoing this procedure (note: lumbar puncture is optional in subjects with DS).\n20. Previous treatment with ACI-24 or any other active immunotherapy against AD at any time in the past unless there is firm evidence that the subject received placebo only and the placebo formulation is not expected to induce any specific immune response.\n21. Previous treatment with any investigational and\u002For marketed passive immunotherapy against AD within 6 months before screening or 5 half-lives, whichever is longer, unless there is firm evidence that the subject received placebo only.\n22. Ongoing treatment with any approved anti-amyloid passive immunotherapy for Alzheimer's disease.\n23. Use of acetylcholinesterase inhibitor or glutamatergic drugs (eg, memantine, topiramate, lamotrigine) if not on stable dose for at least 2 months before screening.\n24. Any vaccine, either live or not, including but not limited to influenza or COVID-19 vaccine, received within 4 weeks before randomization.\n25. Subjects with treated hypothyroidism not on a stable dose of replacement medication for at least 2 months before screening and having clinically significant abnormal serum T4 and\u002For thyroid stimulating hormone at screening.\n26. Subjects undergoing lumbar puncture and being treated with any anticoagulants or antiplatelet drugs, except aspirin at doses of 100 mg daily or lower.\n27. Use of antidepressants (other than selective serotonin reuptake inhibitors\u002Fserotonin-norepinephrine reuptake inhibitors at stable dose); typical antipsychotics; γ-aminobutyric acid agonists (eg, gabapentin); or stimulants (eg, methylphenidate, modafinil). Stable doses of atypical antipsychotics or benzodiazepines are only allowed if this is not considered to influence the safety and the efficacy of the study treatment according to the site investigator and the sponsor medical monitor.\n28. Chronic use of opioid analgesics. A limited treatment duration for acute conditions until 24 hours before cognitive assessment is allowed.\n29. Current use of immunosuppressant or immunomodulating drugs or their use within the 6 months before study screening. Current use of oral steroids or their use within the 3 months before study screening.\n\n    Additional Exclusion Criteria in Study Part 2\n\n    The following are exclusion criteria at the time of randomization but will not be considered as exclusionary after treatment assignment:\n30. Clinical diagnosis of AD dementia in DS as per International Classification of Diseases 10 (ICD-10).\n31. DSQIID \\>20.\n32. Intelligence quotient score \\\u003C40 (KBIT-2).","ALL","35 Years","85 Years",{"count":19,"type":20},304,"ESTIMATED","INTERVENTIONAL",[23,24],"PHASE1","PHASE2","The purpose of this study is to assess the safety, tolerability, immunogenicity and pharmacodynamic effects of ACI-24.060 in subjects with prodromal Alzheimer's disease and in non-demented adults with Down syndrome.",[27,28,29,30,31],"Amyloid Plaque","Beta-Amyloid","DSAD","Prodromal Alzheimer's Disease","Alzheimer's Disease",[33,34,35,27,28,36,37,38,39,40,29,41],"Dementia","Brain Diseases","Central Nervous System Diseases","Down syndrome","Immunogenicity","active immunotherapy","immune response","anti-amyloid therapy","Alzheimer's disease","RECRUITING","2026-05-27",{"date":45,"type":46},"2026-05-29","ACTUAL",{"date":48,"type":46},"2022-06-21",{"date":50,"type":20},"2029-04",{"name":52,"class":53},"AC Immune SA","INDUSTRY",26,{"id":56,"slug":4,"hasResults":10,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":15,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":65,"studyType":66,"phases":4,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":5},"100571857","NCT06725706","Beta Amyloid PET\u002FCT in Various Aβ-Related Disease","Inclusion Criteria:\n\n\\- (i) adult patients (aged 18 years or order); (ii) patients with suspected or new diagnosed or previously treated malignant tumors (supporting evidence may include MRI, CT, tumor markers and pathology report); (iii) patients who had scheduled Aβ PET\u002FCT scan; (iv) patients who were able to provide informed consent (signed by participant, parent or legal representative) and assent according to the guidelines of the Clinical Research Ethics Committee.\n\nExclusion Criteria:\n\n\\- (i) patients with non-malignant lesions; (ii) patients with pregnancy; (iii) the inability or unwillingness of the research participant, parent or legal representative to provide written informed consent.",true,"18 Years","80 Years",{"count":64,"type":20},500,"7 Days","OBSERVATIONAL","To evaluate the potential usefulness of 18F-92\u002FAV45, 11C-PIB positron emission tomography\u002Fcomputed tomography (PET\u002FCT) for the diagnosis of primary and metastatic lesions in various Tau-related disease patients.",[69,28,70],"Amyloid","Neurodegenerative Diseases",[72,73,28],"PET\u002FCT","MRI","2025-06-03",{"date":76,"type":46},"2025-06-04",{"date":78,"type":46},"2012-09-01",{"date":80,"type":20},"2027-12-01",{"name":82,"class":83},"Tianjin Medical University","OTHER",{"id":85,"slug":4,"hasResults":10,"nctId":86,"briefTitle":87,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":60,"sex":15,"minAge":89,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":21,"phases":92,"briefSummary":94,"conditions":95,"keywords":105,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":125},"100572472","NCT06733714","Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Remediation in Older Adults","Inclusion Criteria:\n\n* Healthy subjects over 50 years old, with cognitive complaints\n\nExclusion Criteria:\n\n* Estimated Intelligence Quotient \\\u003C80\n* Dependence on psychoactive substances (DSM-V)\n* Severe psychiatric or neurological disorders\n* Uncorrected visual\u002Fhearing problems\n* History of syncope for an unexplained reason or seizure less than a year ago\n* Previous stroke\n* Use of anticoagulants\n* Intracranial metallic prosthesis or cardiac pacemaker\n* Any contraindication to performing tACS","50 Years",{"count":91,"type":20},40,[93],"NA","BACKGROUND Cognitive decline in older adults, especially those who develop Mild Cognitive Impairment and Alzheimer's Disease, currently has limited options of pharmacological treatments, with modest efficacy.\n\nDigital Cognitive Training (DCT) and Transcranial Alternating Current Stimulation (tACS) are two promising tools for cognitive remediation in this population. In this exploratory study, we investigate feasibility, tolerability and preliminary effects of the association of both interventions in older adults with cognitive complaints.\n\nMETHODS Older adults with cognitive complaints are being enrolled for this study, which comprises 5 daily sessions of 30 minutes of DCT using the BrainHQ platform while simultaneously receiving theta tACS (6Hz, 1.6mA) targeting the Left Dorsolateral Prefrontal Cortex.",[96,97,98,99,100,33,101,102,28,103,104],"Cognitive Dysfunction","Alzheimer Disease","Mild Cognitive Impairment","Cognitive Decline","Frontotemporal Degeneration","Dementia, Vascular","Lewy Body Disease","GFAP","Tau Protein",[106,107,108,109,110,111,112,113,114,115],"tacs","nibs","transcranial alternate current stimulation","mild cognitive impairment","MCI","ALzheimer","Cognition","Elderly","Older Adults","Cognitive enhancement","2024-12-09",{"date":118,"type":46},"2024-12-13",{"date":120,"type":46},"2024-12-02",{"date":122,"type":20},"2027-03-01",{"name":124,"class":83},"Universidade Federal do Rio de Janeiro",1,""]