[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chronic-shoulder-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chronic-shoulder-pain":374},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,48,75,101,121,152,178,228,246,278,302,331,349],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100631555",false,"NCT07502209","Notch vs Midpoint Suprascapular Nerve PRF for Chronic Shoulder Pain","Comparison of Suprascapular Notch and Midpoint Approaches in Pulsed Radiofrequency Treatment of the Suprascapular Nerve on Pain and Function in Patients With Chronic Shoulder Pain","SUPRA-PRF","Inclusion Criteria:\n\n* Patients aged between 40 and 80 years\n* Patients with chronic shoulder pain lasting longer than 3 months\n* Patients diagnosed with rotator cuff-related shoulder pain\n* Patients who show at least 50% pain reduction after diagnostic suprascapular nerve block\n* Patients who provide written informed consent\n\nExclusion Criteria:\n\n* Adhesive capsulitis\n* Previous shoulder surgery\n* Full-thickness rotator cuff tear\n* Neurological disorders affecting the shoulder\n* Pacemaker\n* Coagulopathy or anticoagulant therapy contraindicating intervention\n* Infection at the injection site\n* Severe systemic disease\n* Pregnancy\n* Inability to comply with study protocol","ALL","40 Years","80 Years",{"count":20,"type":21},32,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to compare the effects of pulsed radiofrequency (PRF) treatment of the suprascapular nerve using suprascapular notch and midpoint approaches on pain, shoulder function, and muscle strength in patients with chronic shoulder pain due to rotator cuff tendinopathy. Patients will be randomly assigned to one of the two intervention groups. Clinical evaluations will include pain assessment using the Numeric Rating Scale (NRS), functional assessment using the Shoulder Pain and Disability Index (SPADI), and quality of life assessment using the Short Form-36 (SF-36). In addition, shoulder range of motion will be measured goniometrically, muscle thickness of the supraspinatus and infraspinatus will be evaluated by ultrasonography, and shoulder muscle strength will be assessed using an isokinetic dynamometer. Assessments will be performed at baseline, 24 hours, 1 month, and 3 months after the intervention. The results of this study are expected to provide evidence regarding the optimal approach for PRF treatment of the suprascapular nerve in patients with chronic shoulder pain.",[27,28],"Chronic Shoulder Pain","Rotator Cuff Tendinopathy",[30,31,27,28,32,33,34],"Suprascapular Nerve","Pulsed Radiofrequency","Isokinetic Muscle Strength","Ultrasound Measurement","Shoulder Function","RECRUITING","2026-06-26",{"date":38,"type":39},"2026-06-30","ACTUAL",{"date":41,"type":39},"2026-05-07",{"date":43,"type":21},"2027-08-30",{"name":45,"class":46},"Ankara City Hospital Bilkent","OTHER",1,{"id":49,"slug":4,"hasResults":10,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":10,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":59,"conditions":60,"keywords":61,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":47},"100641704","NCT07654023","Central Sensitization and Functional Outcomes in Chronic Shoulder Pain","The Effects of Central Sensitization and Psychological Factors on Functional Outcomes Following Rehabilitation in Individuals With Chronic Shoulder Pain","SHOULDER-CS","Inclusion Criteria:\n\n* Adults aged 18 years and older\n* Presence of chronic shoulder pain lasting at least 3 months\n* Clinical findings consistent with shoulder-related pain\n* Willingness to participate in a 6-week physiotherapy rehabilitation program\n* Ability to complete study assessments and questionnaires\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* History of shoulder surgery within the previous 6 months\n* Major shoulder trauma within the previous 6 months\n* Serious pathology affecting the shoulder (e.g., infection, tumor, systemic inflammatory disease)\n* Neurological disorders affecting the upper extremity (e.g., cervical radiculopathy, myelopathy, peripheral nerve injury)\n* Severe cognitive impairment\n* Communication problems preventing participation\n* Shoulder injection within the previous 4 weeks\n* Pregnancy","18 Years",{"count":57,"type":21},59,"OBSERVATIONAL","This prospective observational cohort study aims to investigate whether baseline central sensitization and psychological factors predict functional outcomes following rehabilitation in individuals with chronic shoulder pain. Participants with chronic shoulder pain will receive a standardized 6-week physiotherapy and rehabilitation program routinely applied in the clinic. Assessments will be performed before and after treatment, including pain severity, shoulder function, central sensitization symptoms, and psychological factors such as pain catastrophizing. The findings of this study may contribute to a better understanding of biopsychosocial factors affecting rehabilitation outcomes in chronic shoulder pain and help improve individualized rehabilitation approaches.",[27],[62,63,64],"Chronic shoulder pain","Central sensitization","Physical therapy","NOT_YET_RECRUITING","2026-06-13",{"date":68,"type":39},"2026-06-17",{"date":70,"type":21},"2026-06-15",{"date":72,"type":21},"2026-08-01",{"name":74,"class":46},"Pamukkale University",{"id":76,"slug":4,"hasResults":10,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":10,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":83,"briefSummary":84,"conditions":85,"keywords":90,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":47},"100640595","NCT07607691","Ultrasound-Guided PENG Block for Chronic Shoulder Pain","Evaluation of the Analgesic Efficacy and Functional Outcomes of Ultrasound-Guided PENG Block in Chronic Shoulder Pain","Inclusion Criteria:\n\n* Age 18 years or older.\n* Patients presenting with chronic shoulder pain lasting longer than 3 months.\n* Initial pain intensity score greater than 4 on the Numerical Rating Scale (NRS \\> 4).\n* Patients who have not responded to conservative or medical treatments.\n* Voluntary acceptance of the ultrasound-guided shoulder PENG block treatment and compliance with the scheduled follow-up protocol.\n\nExclusion Criteria:\n\n* Patients currently using anticoagulants or diagnosed with coagulation disorders (bleeding diathesis).\n* Patients with psychomotor or cognitive disorders that prevent cooperative evaluation.\n* Presence of active bacterial infection, open wounds, or infectious discharge at the planned needle injection site.\n* History of shoulder surgery at the intervention site within the last 6 months.\n* Known allergy or hypersensitivity to local anesthetics (lidocaine) or corticosteroids (dexamethasone).\n* Pregnant or breastfeeding patients.\n* Patients who reject the procedure or fail to comply with the scheduled follow-up visits.",{"count":82,"type":21},45,[24],"The purpose of this prospective, observational study is to evaluate the clinical and functional outcomes of ultrasound-guided Pericapsular Nerve Group (PENG) block in patients suffering from chronic shoulder pain. Chronic shoulder pain is a highly prevalent musculoskeletal problem that significantly restricts daily activities and diminishes the patient's quality of life. While conservative treatments and various interventional injections are widely used, long-term efficacy can be limited, and systemic side effects may occur. The shoulder PENG block is a novel regional analgesia technique that specifically targets the articular (sensory) branches of the nerves innervating the shoulder joint capsule without affecting the motor branches. In this single-center study, a total of 45 eligible adult patients with chronic shoulder pain who did not respond to conservative medical treatments will receive an ultrasound-guided PENG block as part of their routine clinical care. The procedure will be performed under sterile conditions using a combination of local anesthetic (lidocaine) and dexamethasone. Patient pain levels will be assessed using the Numerical Rating Scale (NRS), shoulder disability and functional status will be measured using the Shoulder Pain and Disability Index (SPADI), and overall patient satisfaction will be evaluated using the Global Perceived Effect (GPE) score. All parameters will be documented at baseline (before the procedure) and at follow-up visits on the 1st week, 4th week (1 month), and 3rd month post-procedure. The investigators aim to determine the efficacy, duration of effect, and safety profile of this intervention.",[27,86,87,88,89],"Pericapsular Nerve Group Block (PENG Block)","Frozen Shoulder","Bursitis","Rotator Cuff Disorders",[91,92],"shoulder pain","pericapsular nerve group block","2026-05-21",{"date":95,"type":39},"2026-05-26",{"date":97,"type":21},"2026-06-01",{"date":99,"type":21},"2026-10-15",{"name":45,"class":46},{"id":102,"slug":4,"hasResults":10,"nctId":103,"briefTitle":104,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":106,"sex":16,"minAge":55,"maxAge":107,"enrollmentInfo":108,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":110,"conditions":111,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":47},"100552381","NCT06472349","Structure and Function of the Upper Trapezius and Its Role in Chronic Shoulder Pain: an Investigation of Kinematics, Morphology, Muscle Quality and Activation Distribution","Inclusion Criteria:\n\n* Chronic shoulder pain group\n\n  * 18-50 years old18-50 years old\n  * unilateral and non-traumatic shoulder pain\n  * pain duration longer than 3 months\n  * pain intensity more than VAS=2 during movement\n  * presence 3 of 5 positive pain provocation tests: Hawkins-Kennedy test, Jobe test, or Neer's test Painful Arc, and Resistance Test against External Rotation.\n* Healthy control group\n\n  * presenting no shoulder pain at rest or during daily activities\n  * negative results of the pain provocation test: Hawkins-Kennedy test, Jobe test, Neer's test, Painful Arc, Resistance Test against External Rotation and Spurling's neck compression test.\n\nExclusion Criteria:\n\n\\- Chronic shoulder pain group\n\n* history of significant shoulder trauma, such as fracture or ultrasonography clinically suspected full thickness cuff tear\n* recent shoulder dislocation in the last 2 years\n* diagnosis of adhesive capsulitis characterized by a gradual and painful loss of both active and passive ROM in all shoulder planes, primarily external rotation\n* shoulder pain originating from the cervical spine by using Spurling's neck compression test\n* shoulder pain owing to the following disorders: arthritis (e.g., rheumatoid arthritis, osteoarthritis of shoulder complex), neurologic (e.g., stroke), neoplastic (e.g., breast cancer). and\u002For referred pain (e.g., visceral referred pain)\n* corticoid injections over the shoulder during 6 months prior to the study\n* history of shoulder and neck surgery",true,"50 Years",{"count":109,"type":21},100,"Prior research has explored factors influencing muscle activation, including muscle thickness, fear avoidance beliefs (kinesiophobia), and somatosensory integration. In individuals with chronic shoulder pain, various characteristics impacting symptoms and treatment outcomes have been identified, such as psychosocial factors, fear avoidance, central sensitization, somatosensory impairments, and brain morphology changes. These shared characteristics affecting both muscle activation and chronic shoulder pain may potentially modulate upper trapezius muscle activation during functional movements in patients with chronic shoulder pain. Notably, there remains a gap in the literature concerning investigations into the upper trapezius muscle's morphology and quality, fear avoidance, central sensitization, somatosensory impairments, and their interplay with upper trapezius muscle activation in chronic shoulder pain patients.\n\nTo address these gaps, this study aims to: this study aims to: 1) compare different methods of measuring clavicular kinematics using an electromagnetic tracking system; 2) establish the reliability and validity of measuring muscle thickness and fat infiltration through ultrasound and magnetic resonance imaging; 3) compare shoulder kinematics, muscle activation, muscle morphology, and muscle fat infiltration in individuals with chronic shoulder pain with matched healthy controls; 4) explore the correlation between the factors that may influence upper trapezius muscle activation, including basic data of the subjects, muscle morphology, and muscle fat infiltration.",[27],"2026-04-09",{"date":114,"type":39},"2026-04-14",{"date":116,"type":39},"2023-12-12",{"date":118,"type":21},"2026-12",{"name":120,"class":46},"National Yang Ming Chiao Tung University",{"id":122,"slug":4,"hasResults":10,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":4,"eligibilityCriteria":126,"healthyVolunteers":106,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":127,"targetDuration":4,"studyType":22,"phases":129,"briefSummary":130,"conditions":131,"keywords":135,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":47},"100614097","NCT07275164","HIIT for Inflammatory-driven Shoulder Pain.","Revolutionizing Musculoskeletal Shoulder Pain Management: High-intensity Interval Training as a Systemic Intervention. A Feasibility Study.","Inclusion Criteria:\n\nShoulder pain group\n\n* Shoulder pain \\> 3 months\n* Diagnosis of rotator cuff related shoulder pain or frozen shoulder\n* Understanding Dutch in speaking and writing.\n\nControl group\n\no Understanding Dutch in speaking and writing\n\nExclusion Criteria:\n\nShoulder pain group\n\n* \\\u003C18 years\n* Shoulder surgery or trauma in past year\n* Neurological, cancer, or neuromuscular disease\n* Osteoarthritis, cervical or AC joint pathology\n* Heavy physical exertion \\\u003C48h before testing\n\nControl group\n\n* \\\u003C18 years\n* recent or recurrent neck\u002Fshoulder pain\n* systemic or neurological disease\n* psychiatric disorders\n* pregnancy\u002Fbreastfeeding\n* pain medication \\\u003C48h before test",{"count":128,"type":21},30,[24],"This feasibility study investigates whether high-intensity interval training (HIIT) is feasible and acceptable for individuals with long-term shoulder pain where low-grade inflammation is suspected. Many patients do not recover fully with current local treatments, and systemic factors such as inflammation, and metabolic changes, additionally disturbances in the functioning of the nervous system often seem to play a role. HIIT is a time-efficient form of exercise that has been shown to improve inflammation and metabolic values and positively influence the balance of the nervous system. In this feasibility study, the investigators are enrolling 15 individuals with persistent shoulder pain (diagnosed with rotator cuff-related shoulder pain or frozen shoulder) with \\>3 months of symptoms, and 15 individuals without shoulder complaints. All participants will undergo measurements of inflammatory levels, glycosylated hemoglobin (HbA1c), blood pressure, body composition, pain sensitivity tests, and complete questionnaires about autonomic complaints and quality of life. Participants with shoulder pain will also perform one personalized HIIT session on a cycle ergometer. The investigators will assess whether participants accept a systemic intervention for their shoulder pain, if they are cooperative, and how they feel about the session; additionally, any side effects will be recorded. The aim is to determine whether HIIT is practically feasible and safe for this group and whether there are indications that systemic factors such as inflammation and nervous system function are associated with persistent shoulder pain. The outcome will determine whether follow-up research with a larger study is worthwhile.",[27,132,87,133,134],"Rotator Cuff Related Shoulder Pain","Shoulder Adhesive Capsulitis","Shoulder Pain",[136,137,138,139,140,141,142],"low-grade inflammation","chronic shoulder pain","autonomic dysfunction","metabolic syndrome","frozen shoulder","rotator cuff related shoulder pain","high intensity interval training","2026-02-10",{"date":145,"type":39},"2026-02-13",{"date":147,"type":39},"2025-12-10",{"date":149,"type":21},"2026-10",{"name":151,"class":46},"Universiteit Antwerpen",{"id":153,"slug":4,"hasResults":10,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":157,"eligibilityCriteria":158,"healthyVolunteers":10,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":159,"targetDuration":4,"studyType":22,"phases":161,"briefSummary":162,"conditions":163,"keywords":165,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":176,"locationsCount":47},"100623140","NCT07392762","Virtual Reality-Supported Exercise for Chronic Musculoskeletal Shoulder Disorders: a Feasibility Study","Virtual Reality-Supported Exercise for Chronic Musculoskeletal Shoulder Disorders: a Feasibility Study (The V-RECS Study)","V-RECS","Inclusion Criteria:\n\n* Adult patients \\>18 years with diagnosed unilateral\u002F bilateral shoulder pain with\u002F without co-existing symptoms of instability and or stiffness (persisting \\> three months) generated from a Musculoskeletal origin\n* Patients who have been referred for conservative management\n* New or follow-up patients\n* Sufficient English to understand written materials\u002Fverbal instruction\u002For accompanied by family\u002Ffriends able to translate\n* Patients who provide informed, written consent to enter the study\n\nExclusion Criteria:\n\n* Unable to provide informed consent\n* On a waiting list for surgery and\u002For injections\n* Referred for post-operative physiotherapy\n* Shoulder pain not originating from an MSK aetiology (such as hemiplegia or peripheral nerve injury)\n* Active history of seizures\n* Other relevant medical conditions deemed inappropriate for patients to participate e.g. visual impairment, unstable psychiatric illnesses.\n* Shoulder pain associated with bone metastasis\n* Currently taking part in any other upper limb research study\n* Patients who do not adequately understand verbal explanations or written information given in English (or are not accompanied by an interpreter\u002Ffamily member).",{"count":160,"type":21},20,[24],"People with long-term (chronic) shoulder disorders caused by injuries, overuse or conditions (such as arthritis) often need physiotherapy. This usually includes exercise therapy to help reduce pain, rebuild strength and make every day activities easier. However, it can be hard to stick to an exercise programme. People may stop due to pain, fear of making the symptoms worse or simply loosing motivation.\n\nVirtual Reality (VR) is a technology that may help people say engaged with their exercise programmes by making exercises more enjoyable and interactive. When using a headset (similar to goggles), people can see and interact with a 3D virtual world. Their movement, especially their hands and arms, are shown as an 'avatar' (a virtual character) in this virtual world. Exercise can feel more like playing a game or engaging with tasks\u002Fchallenges, rather than performing repetitive movements. This shift might help reduce focus on pain and increase motivation. VR also provides real-time feedback, helping people track their progress and adjust their movements instantly. This might lead to more accurate and consistent exercise performance and better recovery outcomes.\n\nBefore we can test whether VR exercise programmes are effective for people with chronic shoulder disorders, we firstly need to understand whether it is practical and acceptable for patients to use. This 'feasibility' study will therefore involve 20 patients with chronic shoulder disorders referred for physiotherapy at the Royal National Orthopaedic Hospital (RNOH) in Stanmore, United Kingdom. Participants will take part in three VR exercise sessions at the RNOH over a three-week period. Levels of pain, quality of life and sleep quality etc. will be measured before and after three weeks. Interviews will also be held up to two weeks after the final session to explore people's experiences and thoughts towards the VR exercise programme. The results will help us decide if a larger study should go ahead.",[134,27,164],"Musculoskeletal Shoulder Pain",[166,167,168,164,27,169],"Virtual Reality","VR","Musculoskeletal Rehabilitation","Shoulder pain disorders","2026-01-29",{"date":172,"type":39},"2026-02-06",{"date":174,"type":21},"2026-01-16",{"date":118,"type":21},{"name":177,"class":46},"Royal National Orthopaedic Hospital NHS Trust",{"id":179,"slug":4,"hasResults":10,"nctId":180,"briefTitle":181,"officialTitle":181,"acronym":4,"eligibilityCriteria":182,"healthyVolunteers":106,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":183,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":185,"conditions":186,"keywords":209,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":47},"100497203","NCT05754190","Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA","INCLUSION CRITERIA \\[General study\\]\n\n* Chronic pain group:\n\n  * Age above 18\n  * Access to a personal smartphone and a stable internet connection\n  * Average pain intensity score of greater than 3 in the past week or\n  * Average pain interference score of greater than 3 in the past week or\n  * Average pain distress score of greater than 3 in the past week\n  * Pain duration: greater than 6 months\n* Acute pain group:\n\n  * Age above 18\n  * Access to a personal smartphone and a stable internet connection\n  * Average pain intensity score of greater than 3 in the past week\n\n    ○ or\n  * Average pain interference score of greater than 3 in the past week\n\n    ○ or\n  * Average pain distress score of greater than 3 in the past week\n  * Pain duration: less than 3 months\n  * Pain cause: Due to recent surgery, injury, acute illness, or childbirth (within the past 3 months)\n* Healthy control group:\n\n  * Age above 18\n  * Access to a personal smartphone and a stable internet connection\n  * Average pain intensity score of less than 3 in the past week\n  * Average pain interference score of less than 3 in the past week\n  * Average pain distress score of less than 3 in the past week\n  * No surgery, injury, acute illness, or childbirth (within the past 3 months)\n* In person EEG testing \\[Sub-Study only\\]:\n\n  * Same as in General App Study Above and additionally:\n  * Current diagnosis of Fibromyalgia, Chronic Low Back Pain or Failed Back Surgery Syndrome OR\n  * No current or prior history of chronic pain\n  * If participant has chronic low back pain or failed back surgery syndrome: are they planning to have either a radio-frequency ablation, back surgery, or spinal cord stimulation implant in the next few months\n  * If participant has chronic low back pain or failed back surgery syndrome: have they received insurance approval for the procedure?\n  * Ok with EEC\u002FECG measures\n\nEXCLUSION CRITERIA \\[General study\\]\n\n* Chronic pain group:\n\n  * recent injury or surgery unrelated to the pain in the past 3 months\n  * difficulty participating for technical\u002Flogistical issues (e.g., no computer, incompatible smartphone, can't commit to 4 months study participation);\n  * Not fluent in English (difficulty understanding questions)\n  * Current primary or metastatic cancer (organic cause of pain)\n* Acute pain group:\n\n  * History of Chronic Pain (Pain lasting for more than 6 months)\n  * difficulty participating for technical\u002Flogistical issues (e.g., no computer, incompatible smartphone, can't commit to 4 months study participation);\n  * Not fluent in English (difficulty understanding questions)\n  * Current primary or metastatic cancer (organic cause of pain)\n* Healthy control group:\n\nHistory of Chronic Pain (Pain lasting for more than 6 months)\n\n* difficulty participating for technical\u002Flogistical issues (e.g., no computer, incompatible smartphone, can't commit to 4 months study participation);\n* Not fluent in English (difficulty understanding questions)\n\n  -In person EEG testing \\[Sub-study only\\]: \\[will interfere with EEG data collection safety or quality\\]:\n* Same as in General App Study Above and additionally:\n* Baldness\n* Pregnancy\n* Dreadlocks\n* Left-handedness\n* Use of a wheelchair\n* Heart failure diagnosis\n* Current or prior experience with acute psychosis or mania\n* implanted pacemaker, neurostimulator or any other head or heart implants\n* require a hearing aid to hear properly\n* claustrophobia\n* metal fragments in the body",{"count":184,"type":21},800,"This study relies on the use of a smartphone application (SOMA) that the investigators developed for tracking daily mood, pain, and activity status in acute pain, chronic pain, and healthy controls over four months.The primary goal of the study is to use fluctuations in daily self-reported symptoms to identify computational predictors of acute-chronic pain transition, pain recovery, and\u002For chronic pain maintenance or flareups. The general study will include anyone with current acute or chronic pain, while a smaller sub-study will use a subset of patients from the chronic pain group who have been diagnosed with chronic low back pain, failed back surgery syndrome, or fibromyalgia. These sub-study participants will first take part in one in-person EEG testing session while completing simple interoception and reinforcement learning tasks and then begin daily use of the SOMA app. Electrophysiologic and behavioral data from the EEG testing session will be used to determine predictors of treatment response in the sub-study.",[187,188,189,190,191,192,193,194,195,196,197,198,199,200,201,202,203,204,205,206,207,208,27],"Chronic Pain","Acute Pain","Post Operative Pain","Fibromyalgia, Primary","Fibromyalgia, Secondary","Fibromyalgia","Irritable Bowel Syndrome","Chronic Headache Disorder","Chronic Migraine","Chronic Pelvic Pain Syndrome","Temporomandibular Joint Disorders","Endometriosis-related Pain","Arthritis","Chronic Low-back Pain","Failed Back Surgery Syndrome","Post Herpetic Neuralgia","Neuropathic Pain","Painful Diabetic Neuropathy","Painful Bladder Syndrome","Trauma-related Wound","Trauma, Multiple","Chronic Pain Syndrome",[210,211,212,213,214,215,216,217,218],"digital health","e-health","smartphone application","chronic pain","acute pain","symptom tracking","experience sampling methodology","ecological momentary assessment","pain self-management","2025-09-16",{"date":221,"type":39},"2025-09-19",{"date":223,"type":39},"2023-06-20",{"date":225,"type":21},"2026-05-30",{"name":227,"class":46},"Brown University",{"id":229,"slug":4,"hasResults":10,"nctId":230,"briefTitle":231,"officialTitle":231,"acronym":4,"eligibilityCriteria":232,"healthyVolunteers":10,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":233,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":235,"conditions":236,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":240,"completionDateStruct":242,"leadSponsor":244,"locationsCount":4},"100597942","NCT07065045","Psychometric Properties Of Translated Arabic Version Of The Fremantle Shoulder Awareness Questionnaire In Patients With Chronic Shoulder Pain","Inclusion Criteria:\n\n* Patients with chronic shoulder pain was aged 18 or more years old .\n* Shoulder pain lasting for more than three months which, after clinical evaluation, was positive in at least three of the following six clinical tests: (1) Hawkins impingement sign; (2) Neer's impingement sign; (3) painful arc sign; (4) Jobe's test; (5) Whipple's test; (6) shoulder pain elicited by resistance testing during shoulder abduction or external rotation.\n* Being conscious and oriented.\n* Able to read and write in Arabic.\n\nExclusion Criteria:\n\n* History of shoulder surgery or planned shoulder surgery.\n* History of fracture, dislocation, or degenerative disease of the shoulder joint.\n* Active shoulder range of motion \\\u003C90 degrees of flexion or abduction or \\\u003C0 degrees of external rotation.\n* Cervical radiculopathy or examination that caused shoulder pain\u002Freduced range of motion after repetitive neck movements.\n* Other serious orthopedic problems.",{"count":234,"type":21},200,"Test the psychometric properties of translated arabic version of the Fremantle shoulder awareness questionnaire in patients with chronic shoulder pain",[27],"2025-07-14",{"date":239,"type":39},"2025-07-15",{"date":241,"type":21},"2025-09-01",{"date":243,"type":21},"2026-02-15",{"name":245,"class":46},"Cairo University",{"id":247,"slug":4,"hasResults":10,"nctId":248,"briefTitle":249,"officialTitle":250,"acronym":4,"eligibilityCriteria":251,"healthyVolunteers":10,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":252,"targetDuration":4,"studyType":22,"phases":254,"briefSummary":255,"conditions":256,"keywords":259,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":268,"lastUpdatePostDateStruct":269,"startDateStruct":271,"completionDateStruct":273,"leadSponsor":275,"locationsCount":277},"100598945","NCT07078084","Laterality Training and Pain Drawings","Laterality Training and Pain Drawings: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Diagnosis of chronic shoulder or knee pain lasting more than 6 months\n* Able to read and understand English\n* Willing to provide written informed consent\n\nExclusion Criteria:\n\n* Visual impairments that would interfere with laterality training (e.g., blindness or significant difficulty with vision)\n* Previous participation in laterality (left\u002Fright discrimination) training\n* Unwilling or unable to participate in the study procedures",{"count":253,"type":21},60,[24],"The goal of this clinical trial is to learn if laterality training (a type of brain-based therapy) can help reduce pain and change how people with chronic musculoskeletal pain experience and describe their pain. The study will focus on adults with shoulder or knee pain lasting longer than 6 months.\n\nThe main questions it aims to answer are:\n\nDoes laterality training lead to a reduction in self-reported pain levels?\n\nDoes laterality training reduce the area of the body that participants indicate as painful in their pain drawings?\n\nDoes laterality training improve accuracy and speed in left\u002Fright judgment tasks?\n\nResearchers will compare participants who complete laterality training to those who complete a non-therapeutic cognitive task (a word puzzle) to see if laterality training changes pain drawings and improves pain outcomes.\n\nParticipants will:\n\nComplete a pre-intervention assessment including pain ratings, pain drawings, and a left\u002Fright judgment test\n\nBe randomly assigned to one of two groups:\n\nIntervention group: Complete 5 one-minute sessions of laterality training using a tablet-based app called Recognise™, identifying left or right hand\u002Ffoot images depending on the location of their pain\n\nControl group: Complete a 10-minute crossword puzzle activity (non-therapeutic)\n\nComplete the same assessments after the activity (pain ratings, pain drawings, left\u002Fright judgment test)\n\nThe study will take place at two outpatient physical therapy clinics. Participation involves a single session lasting approximately 30-45 minutes. There is no cost to participate, and no compensation is provided. Participation is voluntary, and all personal data will be kept confidential.\n\nThis research will help determine whether laterality training, a non-invasive brain-based technique, can reduce pain and improve quality of life in people with long-standing musculoskeletal pain.",[257,27,258],"Chronic Musculoskeletal Pain","Chronic Knee Pain",[260,261,262,263,264,265,266,267],"Chronic musculoskeletal pain","Shoulder pain","Knee pain","Laterality training","Left\u002Fright discrimination","Graded motor imagery","Pain neuroscience","Pain drawings","2025-07-12",{"date":270,"type":39},"2025-07-22",{"date":272,"type":21},"2025-08",{"date":274,"type":21},"2026-02",{"name":276,"class":46},"Hawaii Pacific University",2,{"id":279,"slug":4,"hasResults":10,"nctId":280,"briefTitle":281,"officialTitle":282,"acronym":4,"eligibilityCriteria":283,"healthyVolunteers":10,"sex":16,"minAge":55,"maxAge":284,"enrollmentInfo":285,"targetDuration":4,"studyType":22,"phases":287,"briefSummary":288,"conditions":289,"keywords":290,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":293,"lastUpdatePostDateStruct":294,"startDateStruct":296,"completionDateStruct":298,"leadSponsor":300,"locationsCount":47},"100581784","NCT06854809","Cognitive Functional Therapy Versus Exercises for Chronic Shoulder Pain","Effects of Cognitive Functional Therapy Versus Therapeutic Exercises in Individuals With Chronic Shoulder Pain: A Randomized Controlled Trial","Inclusion Criteria:\n\nIndividuals of both sexes, aged between 18 and 65 years, will be included if they have had shoulder pain for at least 3 months and report a pain intensity of at least 3 points on the Numeric Pain Rating Scale (NPRS) at rest or during arm movement. Additionally, they must have a minimum score of 20 points on the Shoulder Pain and Disability Index (SPADI).\n\nExclusion Criteria:\n\nIndividuals will not be included if they have adhesive capsulitis, defined as a loss of more than 50% of passive shoulder range of motion in external rotation; previous shoulder surgery; a history of shoulder fracture; systemic musculoskeletal diseases (e.g., rheumatoid arthritis, fibromyalgia); shoulder pain reproduced by active or passive cervical spine movement; signs of glenohumeral instability identified by a positive sulcus test or a positive apprehension test indicating laxity in the glenohumeral joint; self-reported systemic disease; a positive drop arm test; pregnancy; active cancer treatment; neurological diseases; cognitive impairments; corticosteroid injection within three months prior to the intervention; or physical therapy in the three months preceding the study.\n\nParticipants will be discontinued from the study if they experience fractures, surgeries, musculoskeletal or neural injuries that prevent access to treatment, or receive corticosteroid injections during the treatment or follow-up period.","65 Years",{"count":286,"type":21},148,[24],"The objective of this clinical trial is to determine whether cognitive functional therapy is superior to therapeutic exercises for the treatment of chronic shoulder pain. The main questions it aims to answer are:\n\nIs cognitive functional therapy superior to therapeutic exercises for pain and disability in individuals with chronic shoulder pain? Is cognitive functional therapy superior to therapeutic exercises for functionality and psychosocial factors?\n\nParticipants will:\n\nReceive 4 to 8 sessions of cognitive functional therapy once a week for four to eight weeks.\n\nFollow a therapeutic exercise protocol for eight weeks with a frequency of twice per week.",[27],[91,291,292],"Psychosocial Rehabilitation","exercise therapy","2025-06-13",{"date":295,"type":39},"2025-06-18",{"date":297,"type":21},"2025-07",{"date":299,"type":21},"2029-03",{"name":301,"class":46},"Universidade Federal de Sao Carlos",{"id":303,"slug":4,"hasResults":10,"nctId":304,"briefTitle":305,"officialTitle":306,"acronym":4,"eligibilityCriteria":307,"healthyVolunteers":10,"sex":16,"minAge":55,"maxAge":308,"enrollmentInfo":309,"targetDuration":4,"studyType":22,"phases":311,"briefSummary":312,"conditions":313,"keywords":315,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":323,"lastUpdatePostDateStruct":324,"startDateStruct":326,"completionDateStruct":327,"leadSponsor":329,"locationsCount":47},"100566938","NCT06661681","Cognitive Functional Therapy for Treating Individuals With Chronic Shoulder Pain","Cognitive Functional Therapy Versus Therapeutic Exercises for the Treatment of Individuals With Chronic Shoulder Pain: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Men or women;\n* Age between 18 and 60 years;\n* Presence of shoulder pain for more than 3 months;\n* Pain intensity of 4 points or more on the 11-point Numeric Pain Rating Scale.\n* High level of disability or moderate level of irritability.\n\nExclusion Criteria:\n\n* History of fracture or surgery of the clavicle, scapula, and\u002For humerus, surgical stabilization or rotator cuff repair;\n* History of dislocation, instability (positive sulcus sign or apprehension test), and\u002For rotator cuff tear (positive drop arm test);\n* Adhesive capsulitis verified by the presence of gradual onset pain associated with stiffness and reduced passive and active mobility;\n* Ongoing pregnancy;\n* Reproduction of shoulder pain radiating to the entire upper limb during cervical or thoracic spine tests (positive Spurling test);\n* Neurological or systemic diseases that may alter muscle strength and sensitivity such as rheumatoid arthritis, fibromyalgia, lupus, gout, and diabetes;\n* Corticosteroid injection in the shoulder region in the last 3 months;\n* Physiotherapy treatment in the last 6 months.\n* Active treatment for cancer","60 Years",{"count":310,"type":21},72,[24],"Shoulder pain is a debilitating musculoskeletal condition with functional, physical, and psychological impacts. Interventions for chronic shoulder pain should address the biopsychosocial model, with Cognitive Functional Therapy emerging as a promising physiotherapy approach. Cognitive Functional Therapy approaches the multidimensional nature of pain, integrating physical and cognitive aspects.\n\nThe aim of this randomized controlled trial is to compare the effects of Cognitive Functional Therapy with therapeutic exercise on biological aspects of pain (pain intensity, disability, function, perception of improvement\u002Fdeterioration, and central pain processing), and psychosocial aspects of pain (sleep quality, self-efficacy, and biopsychosocial factors). The hypothesis of this study is that CFT will lead to greater improvements in these outcomes compared to therapeutic exercise.",[27,314,291],"Exercise Therapy",[261,316,317,318,319,320,321,322],"Subacromial pain","Rotator cuff related shoulder pain","Shoulder Impingement","Chronic pain","Psychosocial","Rehabilitation","Biopsychosocial","2025-02-17",{"date":325,"type":39},"2025-02-19",{"date":323,"type":39},{"date":328,"type":21},"2026-11-25",{"name":330,"class":46},"Federal University of Paraíba",{"id":332,"slug":4,"hasResults":10,"nctId":333,"briefTitle":334,"officialTitle":335,"acronym":4,"eligibilityCriteria":336,"healthyVolunteers":10,"sex":16,"minAge":55,"maxAge":308,"enrollmentInfo":337,"targetDuration":4,"studyType":22,"phases":339,"briefSummary":340,"conditions":341,"keywords":342,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":323,"lastUpdatePostDateStruct":344,"startDateStruct":346,"completionDateStruct":347,"leadSponsor":348,"locationsCount":47},"100557788","NCT06542666","Cognitive Functional Therapy for Chronic Shoulder Pain: Pilot and Feasibility Study","Cognitive Functional Therapy Versus Therapeutic Exercises for Treating Individuals With Chronic Shoulder Pain: A Pilot and Feasibility Study","Inclusion Criteria:\n\n* Men and women;\n* Age between 18 and 60 years;\n* Presence of shoulder pain for more than 3 months;\n* Pain intensity of 4 points or more on the 11-point Numeric Pain Rating Scale during the past week.\n* High level of disability or moderate level of irritability.\n\nExclusion Criteria:\n\n* History of fracture or surgery of the clavicle, scapula, and\u002For humerus, surgical stabilization or rotator cuff repair;\n* History of dislocation, instability (positive sulcus sign or apprehension test), and\u002For rotator cuff tear (positive drop arm test);\n* Adhesive capsulitis verified by the presence of gradual onset pain associated with stiffness and reduced passive and active mobility;\n* Ongoing pregnancy;\n* Reproduction of shoulder pain radiating to the entire upper limb during cervical or thoracic spine tests (positive Spurling test);\n* Neurological or systemic diseases that may alter muscle strength and sensitivity such as rheumatoid arthritis, fibromyalgia, lupus, gout, and diabetes;\n* Corticosteroid injection in the shoulder region in the last 3 months;\n* Physiotherapy treatment in the last 6 months.",{"count":338,"type":21},24,[24],"This pilot randomized controlled clinical trial (RCT) will assess the feasibility and identify the key components necessary for conducting the main RCT, which will involve the comparison of Cognitive Functional Therapy with Therapeutic Exercises in individuals with chronic shoulder pain. The main questions it aims to answer are:\n\n* What barriers to the participation of the included individuals might arise?\n* Will the assessment procedures and outcome measures be feasible and suitable?\n* What time will be necessary to conduct the assessments?\n* Will participants be willing to be randomized to the proposed treatment groups?\n* What barriers to the clinical delivery of Cognitive Functional Therapy in the healthcare system might exist?\n* Will the treatment(s) be acceptable to patients?\n* Will participants adhere to the treatment?\n* What will the recruitment rates be per week\u002Fmonth?\n* Will there be any selection bias?\n* Will participant retention be high among the allocation groups?\n* Will the data be complete?\n* What will the data variability be?\n* Will the treatment effects\u002Foutcomes be consistent with expectations and previous literature?",[27,314,291],[261,316,343,318,319,320,321,322],"Rotator cuff related pain",{"date":345,"type":39},"2025-02-18",{"date":323,"type":39},{"date":241,"type":21},{"name":330,"class":46},{"id":350,"slug":4,"hasResults":10,"nctId":351,"briefTitle":352,"officialTitle":353,"acronym":354,"eligibilityCriteria":355,"healthyVolunteers":10,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":356,"targetDuration":4,"studyType":22,"phases":357,"briefSummary":360,"conditions":361,"keywords":362,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":365,"lastUpdatePostDateStruct":366,"startDateStruct":368,"completionDateStruct":370,"leadSponsor":372,"locationsCount":4},"100342468","NCT03739021","Exparel for Total Shoulder Pain","Analgesic Requirements for Post-operative Pain Control in Total Shoulder Replacement Patients: Comparison of Interscalene Single Shot Exparel (Bupivacaine Liposome) Injections to Cervical Paravertebral Catheter With Ropivacaine (0.2% Continuous Infusion)","ETSP","Inclusion Criteria:\n\n* Patients 18 years or older\n* Patients admitted to TGH for total shoulder replacement surgery\n* Subjects who have given written informed consent\n\nExclusion Criteria:\n\n* Patients with allergic reactions to Exparel or Ropivacaine\n* Female patients who are pregnant\n* Subjects known or suspected to have neuromuscular disorders impairing neuromuscular blockade (e.g., subjects with myasthenia gravis)",{"count":253,"type":21},[358,359],"PHASE2","PHASE3","Total shoulder surgery (arthroplasty) is a widely successful method of treating shoulder arthritis. Although the goal of the procedure is pain relief, post-operative pain is unavoidable. Pain is a common side effect that many patients undergo while in the clinical setting and is a vital factor in influencing the length of hospital stay, narcotic usage, as well as overall patient satisfaction. Post-operative pain management typically involves elevated usage of narcotics, which is a concern among clinicians and researchers alike. To combat this issue, research is examining intraoperative procedures as a means of reducing post-operative pain scores.\n\nResearch has discovered the advantages of utilizing local anesthetic techniques as opposed to just general anesthesia. Local anesthetic blocks function by preventing the generation of nerve impulses by increasing the action-potential threshold, thereby inhibiting movement. Previous studies have demonstrated the success of local anesthetic interscalene blocks across several medical procedures. For instance, Exparel (liposomal bupivacaine) has been effective in reducing post-operative pain scores in tonsillectomy and shoulder arthroplasty. Another local anesthetic, Ropivacaine, has been found to be potent when utilized via a cervical paravertebral catheter among thoracic procedures.\n\nOur study will compare Exparel (bupivacaine liposome) with Ropivacaine continuous infusion for post-operative pain scores in total shoulder surgery patients. Additionally, we will collect data on complications, length of stay, and other variables.",[27],[363,364],"replacement","shoulder","2019-07-15",{"date":367,"type":39},"2019-07-16",{"date":369,"type":21},"2019-11",{"date":371,"type":21},"2020-11-15",{"name":373,"class":46},"University of South Florida",""]