[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"complex-renal-calculi\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:complex-renal-calculi":49},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":5},"100053219",false,"NCT07697677","Modified Mini-PCNL Versus Standard PCNL for Complex Kidney Stones","Modified Mini Percutaneous Nephrolithotomy Versus Standard Percutaneous Nephrolithotomy for the Treatment of Complex Renal Calculi: A Multicenter Randomized Controlled Trial","MIMIC-PCNL","Inclusion Criteria:\n\n1. Adults aged ≥18 years.\n2. Serum creatinine ≤133 μmol\u002FL.\n3. American Society of Anesthesiologists (ASA) physical status classification I-III.\n4. S.T.O.N.E. score ≥8.\n5. Complex renal stones confirmed by noncontrast computed tomography, including stone surface area \\>1500 mm², multiple calyceal stones, partial or complete staghorn calculi, or complex anatomical conditions.\n6. Patients who provide written informed consent and agree to undergo either modified mini-percutaneous nephrolithotomy or standard percutaneous nephrolithotomy.\n\nExclusion Criteria:\n\n1. Solitary kidney.\n2. Morbid obesity (body mass index ≥35 kg\u002Fm²).\n3. Previous renal transplantation or urinary diversion.\n4. Congenital abnormalities of the urinary tract.\n5. Pregnancy.\n6. Uncorrected coagulopathy.\n7. Active urinary tract infection.","ALL","18 Years","70 Years",{"count":20,"type":21},1380,"ESTIMATED","INTERVENTIONAL",[24],"NA","Kidney stones that are large or complex are often treated with percutaneous nephrolithotomy, also called PCNL. Standard PCNL uses a larger access tract and is effective for removing complex kidney stones, but it may be associated with more bleeding, pain, and recovery burden. Modified mini-PCNL uses a smaller access tract and may reduce surgical trauma while maintaining a similar stone clearance rate.\n\nThis multicenter randomized trial will compare modified mini-PCNL using a 20 Fr access sheath with standard PCNL using a 24 Fr access sheath in adults with complex renal stones. About 1,380 participants from 8 urology centers will be randomly assigned to receive one of the two procedures. The main purpose of the study is to determine whether modified mini-PCNL is not worse than standard PCNL in achieving stone-free status shortly after surgery. Stone-free status will be assessed by low-dose noncontrast CT within 72 hours after surgery. The study will also compare stone-free status at 3 months, complications, operation time, length of hospital stay, need for additional procedures, and quality of life.",[27,28],"Kidney Stones","Complex Renal Calculi",[30,31,32,33,34,35,36],"Percutaneous Nephrolithotomy","Mini-PCNL","Standard PCNL","Modified Mini-PCNL","Complex Renal Stones","Stone-Free Rate","Randomized Controlled Trial","RECRUITING","2026-07-07",{"date":40,"type":41},"2026-07-13","ACTUAL",{"date":43,"type":21},"2026-07-15",{"date":45,"type":21},"2027-09-14",{"name":47,"class":48},"The First Affiliated Hospital of Guangzhou Medical University","OTHER",""]