[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ct-perfusion\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ct-perfusion":43},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":12,"acronym":13,"eligibilityCriteria":14,"healthyVolunteers":10,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":20,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100634791",false,"NCT07544277","Spectral and Ultra High Resolution CT Systems for Non-Invasive Detection of Myocardial Ischemia: Stress CT Perfusion VS. FFR-CT","SURE-CT","Inclusion Criteria:\n\n* Patient referred to our hospitals for elective CCTA for ruling out CAD\n* CCTA evidence of moderate stenosis (50-69%) requiring functional assessment according to ESC guidelines\n\nExclusion Criteria:\n\n* hemodynamically unstable conditions,\n* previous revascularization,\n* myocardial infarction,\n* obesity (BMI\\>40 kg\u002Fm2),\n* renal insufficiency (GFR\\\u003C30 mL\u002Fmin),\n* atrial fibrillation or other significant arrhythmias; and\n* other overt cardiovascular diseases affecting CTP performance (e.g., heart failure, severe valvular regurgitation),\n* pregnancy and breastfeeding,\n* contraindications to iodinated contrast agents or regadenoson.","ALL","18 Years",{"count":18,"type":19},142,"ESTIMATED","24 Months","OBSERVATIONAL","Coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. Coronary Computed Tomography angiography (CCTA) gained a pivotal clinical role for excellent sensitivity in rule-out CAD, but has limited specificity for a tendency to overestimate stenoses and for the lack of information about their hemodynamic impact. Fractional Flow Reserve derived from CT (FFR-CT) and stress CT perfusion (CTP) have been recently proposed to complement CCTA in the non-invasive assessment of myocardial ischemia, increasing the specificity and avoiding unnecessary catheterization. However, on energy-integrating (EID)-CT, FFR-CT has suboptimal performance, while CTP is affected by high radiation exposure. Both these approaches may benefit by the introduction of the new Photon Counting Detector (PCD)-CT technology, but data completely lacks. Aim of the study is to assess the performance of PCD-CT in the identification of significant CAD combining CCTA with FFR-CT and spectral CTP.",[24,25,26,27],"FFR-CT","CT Angiography","CT Perfusion","Coronary Arterial Disease (CAD)",[24,29,26,27],"Coronary CT angiography","NOT_YET_RECRUITING","2026-04-15",{"date":33,"type":34},"2026-04-22","ACTUAL",{"date":36,"type":19},"2026-09-01",{"date":38,"type":19},"2029-09-01",{"name":40,"class":41},"IRCCS San Raffaele","OTHER",2,""]